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Protein

Probable G-protein coupled receptor 157

Gene

Gpr157

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 157
Gene namesi
Name:Gpr157
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1311096. Gpr157.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515ExtracellularSequence analysisAdd
BLAST
Transmembranei16 – 3621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini37 – 4812CytoplasmicSequence analysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini70 – 8718ExtracellularSequence analysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini109 – 11911CytoplasmicSequence analysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini141 – 16626ExtracellularSequence analysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini188 – 22740CytoplasmicSequence analysisAdd
BLAST
Transmembranei228 – 25023Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini251 – 2599ExtracellularSequence analysis
Transmembranei260 – 28223Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini283 – 33048CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Probable G-protein coupled receptor 157PRO_0000070341Add
BLAST

Proteomic databases

PaxDbiQ5FVG1.
PRIDEiQ5FVG1.

PTM databases

PhosphoSiteiQ5FVG1.

Structurei

3D structure databases

ProteinModelPortaliQ5FVG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGF4. Eukaryota.
ENOG410XSF0. LUCA.
GeneTreeiENSGT00390000012992.
HOGENOMiHOG000070448.
HOVERGENiHBG055714.
InParanoidiQ5FVG1.
KOiK08467.
OMAiQGAANCI.
OrthoDBiEOG7KH9KD.
PhylomeDBiQ5FVG1.
TreeFamiTF330856.

Family and domain databases

InterProiIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
[Graphical view]
PRINTSiPR02001. GCR1CAMPR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FVG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPAPPTEL LPWERAVVLL SCVLSALGSG LLVATHALWP DLRSRARRLL
60 70 80 90 100
LFLSLADLLS AASYFYGVLQ DFAGTSWDCV LQGALSTFAN TSSFFWTVAI
110 120 130 140 150
ALYLYLNIVR ATRGPCTDHL VWAFHLISWG VPLAITVAAV CLKKIGYDAS
160 170 180 190 200
DVSVGWCWIN LEAEDRVLWM LLTGKLWEML AYILLPLLYL LVRKHINRAH
210 220 230 240 250
QALSEYRPIW EGRQLQRGSP TSMADKKLIL IPFIFICLRV WSTVRFVLTL
260 270 280 290 300
CGSPVVQAPV LVVLHGIGNT FQGGANCIMF VLCTRAVRTR LFSLCCCYPR
310 320 330
PPTQNPPGAS IPPKMGESQE SRRTPEVPST
Length:330
Mass (Da):36,687
Last modified:March 1, 2005 - v1
Checksum:i3EBB6F486CF77151
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090013 mRNA. Translation: AAH90013.1.
RefSeqiNP_001012107.1. NM_001012107.1.
UniGeneiRn.126639.

Genome annotation databases

EnsembliENSRNOT00000055536; ENSRNOP00000052398; ENSRNOG00000017528.
GeneIDi313725.
KEGGirno:313725.
UCSCiRGD:1311096. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090013 mRNA. Translation: AAH90013.1.
RefSeqiNP_001012107.1. NM_001012107.1.
UniGeneiRn.126639.

3D structure databases

ProteinModelPortaliQ5FVG1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ5FVG1.

Proteomic databases

PaxDbiQ5FVG1.
PRIDEiQ5FVG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055536; ENSRNOP00000052398; ENSRNOG00000017528.
GeneIDi313725.
KEGGirno:313725.
UCSCiRGD:1311096. rat.

Organism-specific databases

CTDi80045.
RGDi1311096. Gpr157.

Phylogenomic databases

eggNOGiENOG410IGF4. Eukaryota.
ENOG410XSF0. LUCA.
GeneTreeiENSGT00390000012992.
HOGENOMiHOG000070448.
HOVERGENiHBG055714.
InParanoidiQ5FVG1.
KOiK08467.
OMAiQGAANCI.
OrthoDBiEOG7KH9KD.
PhylomeDBiQ5FVG1.
TreeFamiTF330856.

Miscellaneous databases

PROiQ5FVG1.

Family and domain databases

InterProiIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
[Graphical view]
PRINTSiPR02001. GCR1CAMPR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiGP157_RAT
AccessioniPrimary (citable) accession number: Q5FVG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2005
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.