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Protein

G-protein coupled receptor 157

Gene

Gpr157

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 157
Gene namesi
Name:Gpr157
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi1311096 Gpr157

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15ExtracellularSequence analysisAdd BLAST15
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini37 – 48CytoplasmicSequence analysisAdd BLAST12
Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini70 – 87ExtracellularSequence analysisAdd BLAST18
Transmembranei88 – 108Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini109 – 119CytoplasmicSequence analysisAdd BLAST11
Transmembranei120 – 140Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini141 – 166ExtracellularSequence analysisAdd BLAST26
Transmembranei167 – 187Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini188 – 227CytoplasmicSequence analysisAdd BLAST40
Transmembranei228 – 250Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini251 – 259ExtracellularSequence analysis9
Transmembranei260 – 282Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini283 – 330CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000703411 – 330G-protein coupled receptor 157Add BLAST330

Proteomic databases

PaxDbiQ5FVG1
PRIDEiQ5FVG1

PTM databases

PhosphoSitePlusiQ5FVG1

Expressioni

Gene expression databases

BgeeiENSRNOG00000017528

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052398

Structurei

3D structure databases

ProteinModelPortaliQ5FVG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGF4 Eukaryota
ENOG410XSF0 LUCA
GeneTreeiENSGT00390000012992
HOGENOMiHOG000070448
HOVERGENiHBG055714
InParanoidiQ5FVG1
KOiK08467
OMAiQGAANCI
OrthoDBiEOG091G0LK3
PhylomeDBiQ5FVG1
TreeFamiTF330856

Family and domain databases

InterProiView protein in InterPro
IPR022343 GCR1-cAMP_receptor
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PRINTSiPR02001 GCR1CAMPR
PROSITEiView protein in PROSITE
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FVG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPAPPTEL LPWERAVVLL SCVLSALGSG LLVATHALWP DLRSRARRLL
60 70 80 90 100
LFLSLADLLS AASYFYGVLQ DFAGTSWDCV LQGALSTFAN TSSFFWTVAI
110 120 130 140 150
ALYLYLNIVR ATRGPCTDHL VWAFHLISWG VPLAITVAAV CLKKIGYDAS
160 170 180 190 200
DVSVGWCWIN LEAEDRVLWM LLTGKLWEML AYILLPLLYL LVRKHINRAH
210 220 230 240 250
QALSEYRPIW EGRQLQRGSP TSMADKKLIL IPFIFICLRV WSTVRFVLTL
260 270 280 290 300
CGSPVVQAPV LVVLHGIGNT FQGGANCIMF VLCTRAVRTR LFSLCCCYPR
310 320 330
PPTQNPPGAS IPPKMGESQE SRRTPEVPST
Length:330
Mass (Da):36,687
Last modified:March 1, 2005 - v1
Checksum:i3EBB6F486CF77151
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090013 mRNA Translation: AAH90013.1
RefSeqiNP_001012107.1, NM_001012107.1
UniGeneiRn.126639

Genome annotation databases

EnsembliENSRNOT00000055536; ENSRNOP00000052398; ENSRNOG00000017528
GeneIDi313725
KEGGirno:313725
UCSCiRGD:1311096 rat

Similar proteinsi

Entry informationi

Entry nameiGP157_RAT
AccessioniPrimary (citable) accession number: Q5FVG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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