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Protein

Biotinidase

Gene

Btd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.By similarity

Catalytic activityi

Biotin amide + H2O = biotin + NH3.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Proton acceptorPROSITE-ProRule annotation
Active sitei190 – 1901Proton donorPROSITE-ProRule annotation
Active sitei223 – 2231NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

SABIO-RKQ5FVF9.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotinidase (EC:3.5.1.12)
Short name:
Biotinase
Gene namesi
Name:BtdImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305316. Btd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 521496BiotinidaseSequence analysisPRO_0000292882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence analysis
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence analysis
Glycosylationi380 – 3801N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5FVF9.
PRIDEiQ5FVF9.

Expressioni

Gene expression databases

GenevisibleiQ5FVF9. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057779.

Structurei

3D structure databases

ProteinModelPortaliQ5FVF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 349315CN hydrolasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CN hydrolase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0806. Eukaryota.
COG0388. LUCA.
HOGENOMiHOG000007627.
HOVERGENiHBG003996.
InParanoidiQ5FVF9.
KOiK01435.
OMAiEYYVAAV.
OrthoDBiEOG7HF1J0.
PhylomeDBiQ5FVF9.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FVF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGARTAHAL VFLLGCSALA LGVCSASLEH GEAEYYVAAV YEHRSVLSPN
60 70 80 90 100
PLELSSRQQA LELMKQNLDV YEQQVMAAAQ KGAHIIVFPE DGIHGFNFTR
110 120 130 140 150
TSIYPFLDLM PSPRLVSWNP CLEPFRFNDT EVLQRLSCMA IKGKMFLVAN
160 170 180 190 200
LGTKQPCLGS DPGCPQDGRY QFNTNVAFSD NGTLVGRYRK HNLYFEEAFD
210 220 230 240 250
SPADVDLTTF DTPFAGKFGM FTCFDILFFD PAVRLLRDFE VKHIAYPTAW
260 270 280 290 300
MNQLPLLAAI EIQKAFATAF GVTVLAANIH HPTLGMTGSG IHTPLKSFWY
310 320 330 340 350
HNMDDPEGHL IIARVATNPQ GLVGTENTTS EMDPSHRKFL KVLSGDPYCE
360 370 380 390 400
KDAQEVRCDE AAKWNLNAPP TFHSEMMYDN FTLVPVWGKE GHLQVCSNSL
410 420 430 440 450
CCHLLFERPA LSKELYALGV FDGLHTVHGT YYVQACALVK CGGAGFETCG
460 470 480 490 500
QEISEAEGLF DFHLWGNFST LYVFPLFLTS GMTLDTPDQL GWESDHYFLR
510 520
KRGLSSGLVT AALYGRLYER N
Length:521
Mass (Da):58,021
Last modified:March 1, 2005 - v1
Checksum:i809E61A25C76B269
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090017 mRNA. Translation: AAH90017.1.
RefSeqiNP_001012047.1. NM_001012047.1.
XP_006252673.1. XM_006252611.2.
XP_006252674.1. XM_006252612.1.
XP_006252676.1. XM_006252614.1.
XP_006252677.1. XM_006252615.2.
XP_006252678.1. XM_006252616.2.
XP_006252679.1. XM_006252617.1.
XP_006252680.1. XM_006252618.1.
XP_006252684.1. XM_006252622.2.
XP_008769221.1. XM_008770999.1.
UniGeneiRn.229037.

Genome annotation databases

GeneIDi306262.
KEGGirno:306262.
UCSCiRGD:1305316. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090017 mRNA. Translation: AAH90017.1.
RefSeqiNP_001012047.1. NM_001012047.1.
XP_006252673.1. XM_006252611.2.
XP_006252674.1. XM_006252612.1.
XP_006252676.1. XM_006252614.1.
XP_006252677.1. XM_006252615.2.
XP_006252678.1. XM_006252616.2.
XP_006252679.1. XM_006252617.1.
XP_006252680.1. XM_006252618.1.
XP_006252684.1. XM_006252622.2.
XP_008769221.1. XM_008770999.1.
UniGeneiRn.229037.

3D structure databases

ProteinModelPortaliQ5FVF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057779.

Proteomic databases

PaxDbiQ5FVF9.
PRIDEiQ5FVF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi306262.
KEGGirno:306262.
UCSCiRGD:1305316. rat.

Organism-specific databases

CTDi686.
RGDi1305316. Btd.

Phylogenomic databases

eggNOGiKOG0806. Eukaryota.
COG0388. LUCA.
HOGENOMiHOG000007627.
HOVERGENiHBG003996.
InParanoidiQ5FVF9.
KOiK01435.
OMAiEYYVAAV.
OrthoDBiEOG7HF1J0.
PhylomeDBiQ5FVF9.

Enzyme and pathway databases

SABIO-RKQ5FVF9.

Miscellaneous databases

PROiQ5FVF9.

Gene expression databases

GenevisibleiQ5FVF9. RN.

Family and domain databases

Gene3Di3.60.110.10. 1 hit.
InterProiIPR012101. Biotinidase_euk.
IPR003010. C-N_Hydrolase.
[Graphical view]
PANTHERiPTHR10609. PTHR10609. 1 hit.
PfamiPF00795. CN_hydrolase. 1 hit.
[Graphical view]
PIRSFiPIRSF011861. Biotinidase. 1 hit.
SUPFAMiSSF56317. SSF56317. 1 hit.
PROSITEiPS50263. CN_HYDROLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: LiverImported.

Entry informationi

Entry nameiBTD_RAT
AccessioniPrimary (citable) accession number: Q5FVF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2005
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.