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Protein

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

Gene

Acap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).By similarity

Enzyme regulationi

GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri414 – 43724C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cellular response to nerve growth factor stimulus Source: UniProtKB
  • protein localization to endosome Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Alternative name(s):
Centaurin-beta-2
Short name:
Cnt-b2
Gene namesi
Name:Acap2
Synonyms:Centb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi1562939. Acap2.

Subcellular locationi

GO - Cellular componenti

  • endosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 770770Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2PRO_0000306387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei387 – 3871PhosphoserineBy similarity
Modified residuei521 – 5211PhosphoserineCombined sources
Modified residuei573 – 5731PhosphoserineBy similarity
Modified residuei576 – 5761PhosphoserineBy similarity
Modified residuei734 – 7341PhosphotyrosineBy similarity
Modified residuei767 – 7671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5FVC7.
PRIDEiQ5FVC7.

PTM databases

iPTMnetiQ5FVC7.
PhosphoSiteiQ5FVC7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001730.
ExpressionAtlasiQ5FVC7. baseline and differential.
GenevisibleiQ5FVC7. RN.

Interactioni

Subunit structurei

Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030250.

Structurei

3D structure databases

ProteinModelPortaliQ5FVC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 226221BARSequence analysisAdd
BLAST
Domaini266 – 36196PHPROSITE-ProRule annotationAdd
BLAST
Domaini399 – 520122Arf-GAPPROSITE-ProRule annotationAdd
BLAST
Repeati632 – 66130ANK 1Sequence analysisAdd
BLAST
Repeati665 – 69430ANK 2Sequence analysisAdd
BLAST
Repeati698 – 72730ANK 3Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 Arf-GAP domain.PROSITE-ProRule annotation
Contains 1 BAR domain.Sequence analysis
Contains 1 PH domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri414 – 43724C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

ANK repeat, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0521. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000220815.
HOVERGENiHBG050889.
InParanoidiQ5FVC7.
KOiK12489.
PhylomeDBiQ5FVC7.
TreeFamiTF318315.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 3 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FVC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMTVDFEEC LKDSPRFRAA LEEVEGDVAE LELKLDKLVK LCIAMIDTGK
60 70 80 90 100
AFCAANKQFM NGIRDLAQYS SNDAVVETSL TKFSDSLQEM INFHTILFDQ
110 120 130 140 150
TQRSIKAQLQ NFVKEDLRKF KDAKKQFEKV SEEKENALVK NAQVQRNKQH
160 170 180 190 200
EVEEAANILT ATRKCFRHIA LDYVLQINVL QSKRRSEILK SMLSFMYAHL
210 220 230 240 250
AFFHQGYDLF SELGPYMKDL GAQLDRLVVD AAKEKREMEQ KHSTIQQKDF
260 270 280 290 300
SSDDSKLEYN VDAANGIVME GYLFKRASNA FKTWNRRWFS IQNNQLVYQK
310 320 330 340 350
KFKDSPTVVV EDLRLCTVKH CEDIERRFCF EVVSPTKSCM LQADSEKLRQ
360 370 380 390 400
AWIKAVQTSI ATAYREKGDE SEKLDKKSSP STGSLDSGSE SKEKLLKGES
410 420 430 440 450
ALQRVQCIPG NTSCCDCGLA DPRWASINLG ITLCIECSGI HRSLGVHFSK
460 470 480 490 500
VRSLTLDTWE PELLKLMCEL GNDVINRVYE AKLEKMGVKK PQPGQRQEKE
510 520 530 540 550
AYIRAKYVER KFVDKYSTLL SPSEQEKRII SKSCEDQRLS HTRVSVHTPV
560 570 580 590 600
KSNDSGIQQC SDDGRESLPS TVSANSLYEP EGERQESSVF LDSKHLNPGL
610 620 630 640 650
QLYRASYEKN LPKMAEALAH GADVNWANSD ENQATPLIQA VLGGSLVTCE
660 670 680 690 700
FLLQNGANVN QRDVQGRGPL HHATVLGHTG QVCLFLKRGA NQHATDEEGK
710 720 730 740 750
DPLSIAVEAA NADIVTLLRL ARMNEEMRES EGLYGQPGDE TYQDIFRDFS
760 770
QMASNNPEKL NRFQQDSQKF
Length:770
Mass (Da):87,230
Last modified:March 1, 2005 - v1
Checksum:iB803C7C69B7FE1CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090073 mRNA. Translation: AAH90073.1.
RefSeqiNP_001029178.1. NM_001034006.2.
UniGeneiRn.208307.

Genome annotation databases

EnsembliENSRNOT00000029549; ENSRNOP00000030250; ENSRNOG00000001730.
GeneIDi619382.
KEGGirno:619382.
UCSCiRGD:1562939. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090073 mRNA. Translation: AAH90073.1.
RefSeqiNP_001029178.1. NM_001034006.2.
UniGeneiRn.208307.

3D structure databases

ProteinModelPortaliQ5FVC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030250.

PTM databases

iPTMnetiQ5FVC7.
PhosphoSiteiQ5FVC7.

Proteomic databases

PaxDbiQ5FVC7.
PRIDEiQ5FVC7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000029549; ENSRNOP00000030250; ENSRNOG00000001730.
GeneIDi619382.
KEGGirno:619382.
UCSCiRGD:1562939. rat.

Organism-specific databases

CTDi23527.
RGDi1562939. Acap2.

Phylogenomic databases

eggNOGiKOG0521. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00760000118874.
HOGENOMiHOG000220815.
HOVERGENiHBG050889.
InParanoidiQ5FVC7.
KOiK12489.
PhylomeDBiQ5FVC7.
TreeFamiTF318315.

Miscellaneous databases

PROiQ5FVC7.

Gene expression databases

BgeeiENSRNOG00000001730.
ExpressionAtlasiQ5FVC7. baseline and differential.
GenevisibleiQ5FVC7. RN.

Family and domain databases

Gene3Di1.20.1270.60. 1 hit.
1.25.40.20. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR027267. AH/BAR-dom.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 3 hits.
SM00105. ArfGap. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACAP2_RAT
AccessioniPrimary (citable) accession number: Q5FVC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.