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Q5FUY5

- GLMS_GLUOX

UniProt

Q5FUY5 - GLMS_GLUOX

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, GOX0007
Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei603 – 6031For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciGOXY290633:GHB3-7-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:GOX0007
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
ProteomesiUP000006375: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 608607Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135337Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi290633.GOX0007.

Structurei

3D structure databases

ProteinModelPortaliQ5FUY5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 218217Glutamine amidotransferase type-2
Add
BLAST
Domaini284 – 423140SIS 1
Add
BLAST
Domaini456 – 598143SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5FUY5-1 [UniParc]FASTAAdd to Basket

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MCGICGIVGH QPASPIAFEA LRRLEYRGYD SAGIATLTAS GDIERRRAAG    50
KLDNLEHVLK EHPLPGTTGI GHTRWATHGA PTENNAHPHE AGRVAIVHNG 100
IIENFAELKK ELEAKGRVFR TETDSETVAH LVDDYLGQGL EPREAAFAAI 150
KRLEGAYAIA MIFKDHEGLL IGARHGAPLA VGYGNGEMFL GSDSIALAPM 200
ARKMTYLEDG DWCELTPDHV TIFDMTGAEV SRPVQDLTFM AGQVGKDGYR 250
HYMEKELHEH PVAIGQTLKR ITDPASKRIA LPEMPFDPAQ VPRITITACG 300
SAYYAGMVGR YWLESLARIP VEIDVASEMR YREPPQPDKG VALLISQSGE 350
TADTLGVLRS LKKAGQSIVS VLNVEHSTMG RESDLVLGMD AGPEISVAST 400
KAFTAQLSVL AALAIDFARA RGTMDQAREE RLTASLLDLP SRAAEVFTRT 450
KDIQAMAAVV AQARDVLYLG RGICTPIAFE GALKLKEISY IHAEAYAAGE 500
LKHGPISLID QTVPVVAIAP STILFDKTLS NLQEAKARGG RILAFTDAEG 550
AKRLEGVAEQ VVIMPDVDAF VAPILYAIPV QMLAYEVALL KGTDVDQPRN 600
LAKSVTVE 608
Length:608
Mass (Da):65,655
Last modified:January 23, 2007 - v3
Checksum:i3EF138346B98E657
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000009 Genomic DNA. Translation: AAW59806.1.
RefSeqiYP_190462.1. NC_006677.1.

Genome annotation databases

EnsemblBacteriaiAAW59806; AAW59806; GOX0007.
GeneIDi3249142.
KEGGigox:GOX0007.
PATRICi32607670. VBIGluOxy81109_0231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000009 Genomic DNA. Translation: AAW59806.1 .
RefSeqi YP_190462.1. NC_006677.1.

3D structure databases

ProteinModelPortali Q5FUY5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290633.GOX0007.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW59806 ; AAW59806 ; GOX0007 .
GeneIDi 3249142.
KEGGi gox:GOX0007.
PATRICi 32607670. VBIGluOxy81109_0231.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci GOXY290633:GHB3-7-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
    Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
    Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 621H.

Entry informationi

Entry nameiGLMS_GLUOX
AccessioniPrimary (citable) accession number: Q5FUY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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