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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (GOX2498)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (GOX2498)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109Proton acceptorUniRule annotation1
Metal bindingi129Monovalent cationUniRule annotation1
Binding sitei132ATPUniRule annotation1
Binding sitei184SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 13ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:GOX0081
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
Proteomesi
  • UP000006375 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002675421 – 270Type III pantothenate kinaseAdd BLAST270

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290633.GOX0081

Structurei

3D structure databases

ProteinModelPortaliQ5FUV0
SMRiQ5FUV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 110Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QNB Bacteria
COG1521 LUCA
HOGENOMiHOG000066025
KOiK03525
OMAiHEPWLTL
OrthoDBiPOG091H01V7

Family and domain databases

HAMAPiMF_01274 Pantothen_kinase_3, 1 hit
InterProiView protein in InterPro
IPR004619 Type_III_PanK
PANTHERiPTHR34265 PTHR34265, 1 hit
PfamiView protein in Pfam
PF03309 Pan_kinase, 1 hit
TIGRFAMsiTIGR00671 baf, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FUV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLVIDAGNT NIVFAVHDGE SWLGQWRIST NEARTADEYA AWLLTLFDRV
60 70 80 90 100
GVNAKAITRA IIGTVVPVAL YELRRFCREW LDVVPLVANA RLDWGIDVLV
110 120 130 140 150
DNPNELGADR RLNGLAGREL FGAPLIVVDF GTATTFDVVN SAGQFCGGAI
160 170 180 190 200
APGVNLSIDA LHRAAARLPR MSIGRPTAAI GRNTSVAMRS GLFWGYVGLV
210 220 230 240 250
EGLIHRISDE MDAKPTVIAT GGLAPLFSEG TPLFDVLAPD LTLDGLRLLA
260 270
DRNTGPPLSY SPERSQGIGQ
Length:270
Mass (Da):28,960
Last modified:March 1, 2005 - v1
Checksum:i09B4F806BA142875
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000009 Genomic DNA Translation: AAW59878.1
RefSeqiWP_011251682.1, NZ_LT900338.1

Genome annotation databases

EnsemblBacteriaiAAW59878; AAW59878; GOX0081
GeneIDi29629006
KEGGigox:GOX0081

Similar proteinsi

Entry informationi

Entry nameiCOAX_GLUOX
AccessioniPrimary (citable) accession number: Q5FUV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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