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Protein

Xanthine phosphoribosyltransferase

Gene

gpt

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts on guanine, xanthine and to a lesser extent hypoxanthine.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (gpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102MagnesiumUniRule annotation1
Binding sitei105XanthineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Alternative name(s):
Xanthine-guanine phosphoribosyltransferaseUniRule annotation
Short name:
XGPRTUniRule annotation
Gene namesi
Name:gptUniRule annotation
Ordered Locus Names:GOX0174
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
Proteomesi
  • UP000006375 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001396691 – 168Xanthine phosphoribosyltransferaseAdd BLAST168

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi290633.GOX0174.

Structurei

3D structure databases

ProteinModelPortaliQ5FUI1.
SMRiQ5FUI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 475-phosphoribose 1-diphosphate bindingUniRule annotation2
Regioni105 – 1095-phosphoribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DYA. Bacteria.
COG0503. LUCA.
HOGENOMiHOG000226805.
KOiK00769.
OMAiFHRDCRA.
OrthoDBiPOG091H03MJ.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
HAMAPiMF_01903. XGPRT. 1 hit.
InterProiView protein in InterPro
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023747. Xanthine_Guanine_PRibTrfase.
PfamiView protein in Pfam
PF00156. Pribosyltran. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiView protein in PROSITE
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FUI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTANQTPQTV HYATVTWDQL HRDARLLAAT LMQKHGPFRG IVAITRGGLI
60 70 80 90 100
PAAILGREMG CRLIESVSVI SYAGEEGTQH EPKVVKPPVA AGDGEGFLIV
110 120 130 140 150
DDLVDSGVTA RIVRELLPKA VFACLYAKPE GKPFTDHYVT EVAQDTWVLF
160
PWDTAPLFVP PLVRSEGE
Length:168
Mass (Da):18,318
Last modified:March 1, 2005 - v1
Checksum:i0177AB8F593BFE88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000009 Genomic DNA. Translation: AAW59965.1.
RefSeqiWP_011251768.1. NC_006677.1.

Genome annotation databases

EnsemblBacteriaiAAW59965; AAW59965; GOX0174.
GeneIDi29627093.
KEGGigox:GOX0174.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiXGPT_GLUOX
AccessioniPrimary (citable) accession number: Q5FUI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2005
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families