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Q5FUH9

- RNH_GLUOX

UniProt

Q5FUH9 - RNH_GLUOX

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Protein
Ribonuclease H
Gene
rnhA, GOX0177
Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi16 – 161Magnesium 1 By similarity
Metal bindingi16 – 161Magnesium 2 By similarity
Metal bindingi54 – 541Magnesium 1 By similarity
Metal bindingi76 – 761Magnesium 1 By similarity
Metal bindingi140 – 1401Magnesium 2 By similarity

GO - Molecular functioni

  1. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. RNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciGOXY290633:GHB3-177-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H (EC:3.1.26.4)
Short name:
RNase H
Gene namesi
Name:rnhA
Ordered Locus Names:GOX0177
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
ProteomesiUP000006375: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 150150Ribonuclease HUniRule annotation
PRO_0000332608Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi290633.GOX0177.

Structurei

3D structure databases

ProteinModelPortaliQ5FUH9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 148142RNase H
Add
BLAST

Sequence similaritiesi

Belongs to the RNase H family.
Contains 1 RNase H domain.

Phylogenomic databases

eggNOGiCOG0328.
HOGENOMiHOG000040465.
KOiK03469.
OMAiRKQVEIF.
OrthoDBiEOG696BTR.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00042. RNase_H.
InterProiIPR022892. RNaseH.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50879. RNASE_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FUH9-1 [UniParc]FASTAAdd to Basket

« Hide

MSEASGERPR VEIWTDGGCK PNPGPGGWGA LLVCRGQEKE LLGGDPETTN    50
NRMELTAAAE ALEALKRPCI VTLHTDSEYL RNGITRWHTG WVRRKWRNAA 100
GDPVANMDLW QRILEAAKPH EIDWLWVKGH SGDENNERVD QLATRGREEL 150
Length:150
Mass (Da):16,878
Last modified:March 1, 2005 - v1
Checksum:i05DD704AFE043CEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000009 Genomic DNA. Translation: AAW59967.1.
RefSeqiYP_190623.1. NC_006677.1.

Genome annotation databases

EnsemblBacteriaiAAW59967; AAW59967; GOX0177.
GeneIDi3248733.
KEGGigox:GOX0177.
PATRICi32608030. VBIGluOxy81109_0402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000009 Genomic DNA. Translation: AAW59967.1 .
RefSeqi YP_190623.1. NC_006677.1.

3D structure databases

ProteinModelPortali Q5FUH9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 290633.GOX0177.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW59967 ; AAW59967 ; GOX0177 .
GeneIDi 3248733.
KEGGi gox:GOX0177.
PATRICi 32608030. VBIGluOxy81109_0402.

Phylogenomic databases

eggNOGi COG0328.
HOGENOMi HOG000040465.
KOi K03469.
OMAi RKQVEIF.
OrthoDBi EOG696BTR.

Enzyme and pathway databases

BioCyci GOXY290633:GHB3-177-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00042. RNase_H.
InterProi IPR022892. RNaseH.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS50879. RNASE_H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
    Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
    Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 621H.

Entry informationi

Entry nameiRNH_GLUOX
AccessioniPrimary (citable) accession number: Q5FUH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2005
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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