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Q5FUH9

- RNH_GLUOX

UniProt

Q5FUH9 - RNH_GLUOX

Protein

Ribonuclease H

Gene

rnhA

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi16 – 161Magnesium 1UniRule annotation
    Metal bindingi16 – 161Magnesium 2UniRule annotation
    Metal bindingi54 – 541Magnesium 1UniRule annotation
    Metal bindingi76 – 761Magnesium 1UniRule annotation
    Metal bindingi140 – 1401Magnesium 2UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. nucleic acid binding Source: InterPro
    3. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. RNA catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciGOXY290633:GHB3-177-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease HUniRule annotation (EC:3.1.26.4UniRule annotation)
    Short name:
    RNase HUniRule annotation
    Gene namesi
    Name:rnhAUniRule annotation
    Ordered Locus Names:GOX0177
    OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
    Taxonomic identifieri290633 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
    ProteomesiUP000006375: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 150150Ribonuclease HPRO_0000332608Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi290633.GOX0177.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FUH9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 148142RNase HUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RNase H family.UniRule annotation
    Contains 1 RNase H domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0328.
    HOGENOMiHOG000040465.
    KOiK03469.
    OMAiRKQVEIF.
    OrthoDBiEOG696BTR.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00042. RNase_H.
    InterProiIPR022892. RNaseH.
    IPR012337. RNaseH-like_dom.
    IPR002156. RNaseH_domain.
    [Graphical view]
    PfamiPF00075. RNase_H. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.
    PROSITEiPS50879. RNASE_H. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FUH9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEASGERPR VEIWTDGGCK PNPGPGGWGA LLVCRGQEKE LLGGDPETTN    50
    NRMELTAAAE ALEALKRPCI VTLHTDSEYL RNGITRWHTG WVRRKWRNAA 100
    GDPVANMDLW QRILEAAKPH EIDWLWVKGH SGDENNERVD QLATRGREEL 150
    Length:150
    Mass (Da):16,878
    Last modified:March 1, 2005 - v1
    Checksum:i05DD704AFE043CEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000009 Genomic DNA. Translation: AAW59967.1.
    RefSeqiYP_190623.1. NC_006677.1.

    Genome annotation databases

    EnsemblBacteriaiAAW59967; AAW59967; GOX0177.
    GeneIDi3248733.
    KEGGigox:GOX0177.
    PATRICi32608030. VBIGluOxy81109_0402.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000009 Genomic DNA. Translation: AAW59967.1 .
    RefSeqi YP_190623.1. NC_006677.1.

    3D structure databases

    ProteinModelPortali Q5FUH9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290633.GOX0177.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW59967 ; AAW59967 ; GOX0177 .
    GeneIDi 3248733.
    KEGGi gox:GOX0177.
    PATRICi 32608030. VBIGluOxy81109_0402.

    Phylogenomic databases

    eggNOGi COG0328.
    HOGENOMi HOG000040465.
    KOi K03469.
    OMAi RKQVEIF.
    OrthoDBi EOG696BTR.

    Enzyme and pathway databases

    BioCyci GOXY290633:GHB3-177-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00042. RNase_H.
    InterProi IPR022892. RNaseH.
    IPR012337. RNaseH-like_dom.
    IPR002156. RNaseH_domain.
    [Graphical view ]
    Pfami PF00075. RNase_H. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    PROSITEi PS50879. RNASE_H. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
      Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
      Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 621H.

    Entry informationi

    Entry nameiRNH_GLUOX
    AccessioniPrimary (citable) accession number: Q5FUH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3