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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481

Protein family/group databases

CAZyiGT19 Glycosyltransferase Family 19

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:GOX0260
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
Proteomesi
  • UP000006375 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002551851 – 415Lipid-A-disaccharide synthaseAdd BLAST415

Proteomic databases

PRIDEiQ5FUA3

Interactioni

Protein-protein interaction databases

STRINGi290633.GOX0260

Structurei

3D structure databases

ProteinModelPortaliQ5FUA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0V Bacteria
COG0763 LUCA
HOGENOMiHOG000018004
KOiK00748
OMAiPTVWAWR
OrthoDBiPOG091H01NW

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF02684 LpxB, 1 hit
TIGRFAMsiTIGR00215 lpxB, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FUA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSLPESGSD GQSSADPSQK ATSLPRYGRV IWILAGEASG DVIGARLMQA
60 70 80 90 100
LHAQDPSLVF AGVGGGRMEA LGLHSLFPMS DLAVMGLVEV VPRLRQLSQR
110 120 130 140 150
LLEAVQDIEL RKPDLVVTID SPGFTLRLLQ KIERSGIKRV HYVAPQVWAW
160 170 180 190 200
RENRVKEFPG LWDRLLCLLP FEPDWFAQRG LEGRFVGHPV LQSGVRQGNA
210 220 230 240 250
QRFRLRHNIP AHAPVVILMP GSRRSEAPRL LPVFRKMLDI LRVQYPDICP
260 270 280 290 300
VIPVAPVIAP TIRQLIRKWP IQPHIVTDIH DKHDAFAAAQ CALTKSGTST
310 320 330 340 350
LELAMGNVPM AVTYRVNPVT ATIARRLIKV PHVAMVNLLA GREVVPELLQ
360 370 380 390 400
ENCTPKKLAE TVSKLLSDPQ MVEKQRMAFA DVLDKLSPPV GTPADAAAAE
410
IMDLLNEPVS RSSRS
Length:415
Mass (Da):45,766
Last modified:March 1, 2005 - v1
Checksum:i646CD6305F61E91C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000009 Genomic DNA Translation: AAW60043.1
RefSeqiWP_011251846.1, NZ_LT900338.1

Genome annotation databases

EnsemblBacteriaiAAW60043; AAW60043; GOX0260
GeneIDi29629263
KEGGigox:GOX0260

Similar proteinsi

Entry informationi

Entry nameiLPXB_GLUOX
AccessioniPrimary (citable) accession number: Q5FUA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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