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Q5FTV3

- SYL_GLUOX

UniProt

Q5FTV3 - SYL_GLUOX

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei629 – 6291ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGOXY290633:GHB3-410-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:GOX0410
    OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
    Taxonomic identifieri290633 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
    ProteomesiUP000006375: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 865865Leucine--tRNA ligasePRO_1000071111Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290633.GOX0410.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FTV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi48 – 5811"HIGH" regionAdd
    BLAST
    Motifi626 – 6305"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FTV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDTTAPAFD FQDREPFWQN EWKRRNTFAV PDVPPADRPK YYVLEMFPYP    50
    SGQLHVGHVR NYTLGDVVAR YKRARGFAVM HPMGWDAFGL PAENAARERN 100
    VHPGKWTMDN IATMRGTLQR LGFSLDWDRE IATCLPEYYG KQQKLFTDML 150
    GAGLVERRDS LVNWDPVDET VLANEQVVDG RGWRSGALIE KKKLSQWFLK 200
    ITKFAQPLLD DLKTLDRWPE RVRTMQERWI GRSEGARVRF ALHQPPAGYD 250
    EDLDSVEVFT TRPDTLFGLS FIGISAEHPL ARKVAESNPQ AAAFIEECRR 300
    LGTSEEVIEA AEKRGFDTGL RVANPLDPEK TAPVWIANFV LMDYGTGAVF 350
    GCPCGDQRDL DFARKYDLPV PQVLLPPGQD AETFVLGKKA VSGDATLFNS 400
    GFLDGLDPAA ARTKVIERLE GLGAGKGVVN WRLRDWGISR QRYWGCPIPI 450
    IHCDTCGPVP VPDEQLPVIL PEDVTFDRPG NPLDHHPTWK HVNCPHCGKP 500
    AVRETDTFDT FVDSSWYFAR FTSPHAETPT VPAAANGWLP VDQYIGGIEH 550
    AILHLLYARF FTRAMHETGH LDVDEPFAGL FTQGMVTHES YRDDSGWLYP 600
    EEVERQGDQV VRRETGTPVQ VGRSEKMSKS KRNTVSPVDI IERYGADTAR 650
    WFVLSDSPPE RDMEWTAAGV AAAARFGQRL HRLVASVAAR DAADSAHGAT 700
    GDDLRRVTHR TIAAVGEALE AFTPNVAVAR LHELTSALAD AERIEGAGIA 750
    AARREAARVL CLLTAPMMPH LAEDMMAVLE PGSALVVERP WPEAEEKWLA 800
    VQSVTIGVQI LGKLRGTIEV PPNAPKEEVL AAAKSEPNVA RLLEGKRLVK 850
    EIHVPNRIVN FVVAG 865
    Length:865
    Mass (Da):96,309
    Last modified:March 1, 2005 - v1
    Checksum:i0CF6FE1B0AEE3F43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000009 Genomic DNA. Translation: AAW60193.1.
    RefSeqiYP_190849.1. NC_006677.1.

    Genome annotation databases

    EnsemblBacteriaiAAW60193; AAW60193; GOX0410.
    GeneIDi3250365.
    KEGGigox:GOX0410.
    PATRICi32608518. VBIGluOxy81109_0640.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000009 Genomic DNA. Translation: AAW60193.1 .
    RefSeqi YP_190849.1. NC_006677.1.

    3D structure databases

    ProteinModelPortali Q5FTV3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290633.GOX0410.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW60193 ; AAW60193 ; GOX0410 .
    GeneIDi 3250365.
    KEGGi gox:GOX0410.
    PATRICi 32608518. VBIGluOxy81109_0640.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci GOXY290633:GHB3-410-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
      Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
      Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 621H.

    Entry informationi

    Entry nameiSYL_GLUOX
    AccessioniPrimary (citable) accession number: Q5FTV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3