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Q5FTV3

- SYL_GLUOX

UniProt

Q5FTV3 - SYL_GLUOX

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Protein
Leucine--tRNA ligase
Gene
leuS, GOX0410
Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei629 – 6291ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGOXY290633:GHB3-410-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:GOX0410
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
ProteomesiUP000006375: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 865865Leucine--tRNA ligaseUniRule annotation
PRO_1000071111Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290633.GOX0410.

Structurei

3D structure databases

ProteinModelPortaliQ5FTV3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionUniRule annotation
Add
BLAST
Motifi626 – 6305"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FTV3-1 [UniParc]FASTAAdd to Basket

« Hide

MSDTTAPAFD FQDREPFWQN EWKRRNTFAV PDVPPADRPK YYVLEMFPYP    50
SGQLHVGHVR NYTLGDVVAR YKRARGFAVM HPMGWDAFGL PAENAARERN 100
VHPGKWTMDN IATMRGTLQR LGFSLDWDRE IATCLPEYYG KQQKLFTDML 150
GAGLVERRDS LVNWDPVDET VLANEQVVDG RGWRSGALIE KKKLSQWFLK 200
ITKFAQPLLD DLKTLDRWPE RVRTMQERWI GRSEGARVRF ALHQPPAGYD 250
EDLDSVEVFT TRPDTLFGLS FIGISAEHPL ARKVAESNPQ AAAFIEECRR 300
LGTSEEVIEA AEKRGFDTGL RVANPLDPEK TAPVWIANFV LMDYGTGAVF 350
GCPCGDQRDL DFARKYDLPV PQVLLPPGQD AETFVLGKKA VSGDATLFNS 400
GFLDGLDPAA ARTKVIERLE GLGAGKGVVN WRLRDWGISR QRYWGCPIPI 450
IHCDTCGPVP VPDEQLPVIL PEDVTFDRPG NPLDHHPTWK HVNCPHCGKP 500
AVRETDTFDT FVDSSWYFAR FTSPHAETPT VPAAANGWLP VDQYIGGIEH 550
AILHLLYARF FTRAMHETGH LDVDEPFAGL FTQGMVTHES YRDDSGWLYP 600
EEVERQGDQV VRRETGTPVQ VGRSEKMSKS KRNTVSPVDI IERYGADTAR 650
WFVLSDSPPE RDMEWTAAGV AAAARFGQRL HRLVASVAAR DAADSAHGAT 700
GDDLRRVTHR TIAAVGEALE AFTPNVAVAR LHELTSALAD AERIEGAGIA 750
AARREAARVL CLLTAPMMPH LAEDMMAVLE PGSALVVERP WPEAEEKWLA 800
VQSVTIGVQI LGKLRGTIEV PPNAPKEEVL AAAKSEPNVA RLLEGKRLVK 850
EIHVPNRIVN FVVAG 865
Length:865
Mass (Da):96,309
Last modified:March 1, 2005 - v1
Checksum:i0CF6FE1B0AEE3F43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000009 Genomic DNA. Translation: AAW60193.1.
RefSeqiYP_190849.1. NC_006677.1.

Genome annotation databases

EnsemblBacteriaiAAW60193; AAW60193; GOX0410.
GeneIDi3250365.
KEGGigox:GOX0410.
PATRICi32608518. VBIGluOxy81109_0640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000009 Genomic DNA. Translation: AAW60193.1 .
RefSeqi YP_190849.1. NC_006677.1.

3D structure databases

ProteinModelPortali Q5FTV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290633.GOX0410.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW60193 ; AAW60193 ; GOX0410 .
GeneIDi 3250365.
KEGGi gox:GOX0410.
PATRICi 32608518. VBIGluOxy81109_0640.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GOXY290633:GHB3-410-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
    Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
    Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 621H.

Entry informationi

Entry nameiSYL_GLUOX
AccessioniPrimary (citable) accession number: Q5FTV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2005
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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