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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei629 – 6291ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGOXY290633:GHB3-410-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:GOX0410
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
ProteomesiUP000006375 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 865865Leucine--tRNA ligasePRO_1000071111Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290633.GOX0410.

Structurei

3D structure databases

ProteinModelPortaliQ5FTV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionAdd
BLAST
Motifi626 – 6305"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FTV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTTAPAFD FQDREPFWQN EWKRRNTFAV PDVPPADRPK YYVLEMFPYP
60 70 80 90 100
SGQLHVGHVR NYTLGDVVAR YKRARGFAVM HPMGWDAFGL PAENAARERN
110 120 130 140 150
VHPGKWTMDN IATMRGTLQR LGFSLDWDRE IATCLPEYYG KQQKLFTDML
160 170 180 190 200
GAGLVERRDS LVNWDPVDET VLANEQVVDG RGWRSGALIE KKKLSQWFLK
210 220 230 240 250
ITKFAQPLLD DLKTLDRWPE RVRTMQERWI GRSEGARVRF ALHQPPAGYD
260 270 280 290 300
EDLDSVEVFT TRPDTLFGLS FIGISAEHPL ARKVAESNPQ AAAFIEECRR
310 320 330 340 350
LGTSEEVIEA AEKRGFDTGL RVANPLDPEK TAPVWIANFV LMDYGTGAVF
360 370 380 390 400
GCPCGDQRDL DFARKYDLPV PQVLLPPGQD AETFVLGKKA VSGDATLFNS
410 420 430 440 450
GFLDGLDPAA ARTKVIERLE GLGAGKGVVN WRLRDWGISR QRYWGCPIPI
460 470 480 490 500
IHCDTCGPVP VPDEQLPVIL PEDVTFDRPG NPLDHHPTWK HVNCPHCGKP
510 520 530 540 550
AVRETDTFDT FVDSSWYFAR FTSPHAETPT VPAAANGWLP VDQYIGGIEH
560 570 580 590 600
AILHLLYARF FTRAMHETGH LDVDEPFAGL FTQGMVTHES YRDDSGWLYP
610 620 630 640 650
EEVERQGDQV VRRETGTPVQ VGRSEKMSKS KRNTVSPVDI IERYGADTAR
660 670 680 690 700
WFVLSDSPPE RDMEWTAAGV AAAARFGQRL HRLVASVAAR DAADSAHGAT
710 720 730 740 750
GDDLRRVTHR TIAAVGEALE AFTPNVAVAR LHELTSALAD AERIEGAGIA
760 770 780 790 800
AARREAARVL CLLTAPMMPH LAEDMMAVLE PGSALVVERP WPEAEEKWLA
810 820 830 840 850
VQSVTIGVQI LGKLRGTIEV PPNAPKEEVL AAAKSEPNVA RLLEGKRLVK
860
EIHVPNRIVN FVVAG
Length:865
Mass (Da):96,309
Last modified:March 1, 2005 - v1
Checksum:i0CF6FE1B0AEE3F43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000009 Genomic DNA. Translation: AAW60193.1.
RefSeqiWP_011251994.1. NC_006677.1.

Genome annotation databases

EnsemblBacteriaiAAW60193; AAW60193; GOX0410.
KEGGigox:GOX0410.
PATRICi32608518. VBIGluOxy81109_0640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000009 Genomic DNA. Translation: AAW60193.1.
RefSeqiWP_011251994.1. NC_006677.1.

3D structure databases

ProteinModelPortaliQ5FTV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290633.GOX0410.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW60193; AAW60193; GOX0410.
KEGGigox:GOX0410.
PATRICi32608518. VBIGluOxy81109_0640.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiEGAHRFI.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciGOXY290633:GHB3-410-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
    Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
    Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 621H.

Entry informationi

Entry nameiSYL_GLUOX
AccessioniPrimary (citable) accession number: Q5FTV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2005
Last modified: July 22, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.