Q5FT39 (TPMT_GLUOX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiopurine S-methyltransferase
EC=2.1.1.67

Alternative name(s):
Thiopurine methyltransferase

Gene names

Name:	tpm
Ordered Locus Names:	GOX0680

Organism

Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) [Complete proteome] [HAMAP]

Taxonomic identifier

290633 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconobacter

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812
Subcellular location	Cytoplasm By similarity HAMAP MF_00812.
Sequence similarities	Belongs to the methyltransferase superfamily. TPMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thiopurine S-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Thiopurine S-methyltransferase HAMAP MF_00812		PRO_0000220120
Sites
	Binding site	14	1	S-adenosyl-L-methionine By similarity
	Binding site	49	1	S-adenosyl-L-methionine; via carbonyl oxygen By similarity
	Binding site	70	1	S-adenosyl-L-methionine By similarity
	Binding site	127	1	S-adenosyl-L-methionine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5FT39 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 19F71CFB1B1FC3E1	FASTA	220	24,241
	10 20 30 40 50 60 MDAKSNAVFW QEKWERGETG FHEPQANPLL TRHIAALDLP AGARIFVPLC GMSQDMVWLA 70 80 90 100 110 120 GQGFHVTGCE LSDIAVHRFF NDLDLTPDIR DVGPLRCFSA GTIRIFAGNI FDLTPDLLGL 130 140 150 160 170 180 MDGIYDRAAL IALPEDLRRA YAAHLLSLTG PVPELLVTLD YDQSCLKGPP FSVDEAFLRE 190 200 210 220 CYGQAYAFTL LESRAVEGGL KGRCPASENV WRFSPLPPSS

References

[1]

"Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans." Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U. Nat. Biotechnol. 23:195-200(2005) [PubMed: 15665824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 621H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000009 Genomic DNA. Translation: AAW60457.1.
RefSeq	YP_191113.1. NC_006677.1.
3D structure databases
ProteinModelPortal	Q5FT39.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3250783.
GenomeReviews	Gene locus GOX0680 in contig CP000009_GR.
KEGG	gox:GOX0680.
NMPDR	fig|290633.1.peg.658.
PATRIC	32609086. VBIGluOxy81109_0920.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG444929.
OMA	QGDIFTL.
Enzyme and pathway databases
BioCyc	GOXY290633:GOX0680-MONOMER.
Family and domain databases
HAMAP	MF_00812. Thiopur_methtran. [Tree]
InterPro	IPR022474. Thiopur_S-MeTfrase_Se/Te_detox. IPR008854. Thiopurine_S-MeTrfase. IPR016822. Thiopurine_S-MeTrfase_sub. [Graphical view]
KO	K00569.
PANTHER	PTHR10259. PTHR10259. 1 hit.
Pfam	PF05724. TPMT. 1 hit. [Graphical view]
PIRSF	PIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
TIGRFAMs	TIGR03840. TMPT_Se_Te. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPMT_GLUOX

Accession

Primary (citable) accession number: Q5FT39

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program