Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA polymerase IV

Gene

dinB

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10MagnesiumUniRule annotation1
Sitei15Substrate discriminationUniRule annotation1
Metal bindingi104MagnesiumUniRule annotation1
Active sitei105UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase IVUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IVUniRule annotation
Gene namesi
Name:dinBUniRule annotation
Ordered Locus Names:GOX0844
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
Proteomesi
  • UP000006375 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001640021 – 356DNA polymerase IVAdd BLAST356

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi290633.GOX0844

Structurei

3D structure databases

ProteinModelPortaliQ5FSM8
SMRiQ5FSM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 186UmuCUniRule annotationAdd BLAST181

Sequence similaritiesi

Belongs to the DNA polymerase type-Y family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SFH Bacteria
COG0389 LUCA
HOGENOMiHOG000082707
KOiK02346
OMAiDMQSFYA
OrthoDBiPOG091H014I

Family and domain databases

CDDicd03586 PolY_Pol_IV_kappa, 1 hit
Gene3Di3.30.1490.100, 1 hit
HAMAPiMF_01113 DNApol_IV, 1 hit
InterProiView protein in InterPro
IPR036775 DNA_pol_Y-fam_lit_finger_sf
IPR017961 DNA_pol_Y-fam_little_finger
IPR022880 DNApol_IV
IPR001126 UmuC
PfamiView protein in Pfam
PF00817 IMS, 1 hit
PF11799 IMS_C, 1 hit
SUPFAMiSSF100879 SSF100879, 1 hit
PROSITEiView protein in PROSITE
PS50173 UMUC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FSM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQRRIVHID MDAFYASVKQ RDDPSLRGRP LAVGRGEARG VVAAASYEAR
60 70 80 90 100
RFGVRSAMPS VTAKRLCPEL LFVPARFDVY RSVSAQIHDI FSRYTPLIQP
110 120 130 140 150
LSLDEAYLDL TDHLGAYGSA TLVADRIRAD IHAETGLTAS AGVSYNRFLA
160 170 180 190 200
KLASDYRKPD GLFVITPAMG PEFVAALPVD AFHGIGPAMA RKMRALGIET
210 220 230 240 250
GADLRERDIE TLTRHFGKAA TFYYGISRGI DHRPVVVNRE RKSLGTEQTY
260 270 280 290 300
LRDLTSEADA HQALTQIAAT LWGSAQRRQL QARTVTLKVK YADFRQITRA
310 320 330 340 350
RTLSAPVPSE EVLLETGQSL MAPLFPFVPG VRLLGLTLSG FHAAESPPCD

QMELLF
Length:356
Mass (Da):39,289
Last modified:March 1, 2005 - v1
Checksum:i16AE487F80ECB7E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000009 Genomic DNA Translation: AAW60618.1
RefSeqiWP_011252414.1, NZ_LT900338.1

Genome annotation databases

EnsemblBacteriaiAAW60618; AAW60618; GOX0844
GeneIDi29629042
KEGGigox:GOX0844

Similar proteinsi

Entry informationi

Entry nameiDPO4_GLUOX
AccessioniPrimary (citable) accession number: Q5FSM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 1, 2005
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health