Q5FS85 (KGUA_GLUOX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	GOX0989

Organism

Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) [Complete proteome] [HAMAP]

Taxonomic identifier

290633 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconobacter › Gluconobacter oxydans

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000266330
Regions
	Domain	8 – 187	180	Guanylate kinase-like
	Nucleotide binding	15 – 22	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5FS85 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: 3B886505D0CA2F28	FASTA	208	23,244
	10 20 30 40 50 60 MTQLPRRGVC LVISAPSGAG KSTIANALRA SEPTLRHSVS VTTRSPRPGE VEGVHYHFRD 70 80 90 100 110 120 IAEFRRMAAD GELLEWAEVF GRGYGTPRAP VEEALDAGHD MVFDIDWQGH RLLRAALPDD 130 140 150 160 170 180 VVSLFVLPPS LEELERRLNK RASDHPEEIA RRMKAALDEI SHWSEFDHTI INSDLDTAIS 190 200 QARSVLTAAR LATRRQRNLL DMVASFSR

References

[1]

"Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans." Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U. Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 621H.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000009 Genomic DNA. Translation: AAW60761.1.
RefSeq	YP_191417.1. NC_006677.1.
3D structure databases
HSSP	HSSP built from PDB template 2AN9 based on UniProtKB P60546.
ProteinModelPortal	Q5FS85.
ModBase	Search...
Protein-protein interaction databases
STRING	290633.GOX0989.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAW60761; AAW60761; GOX0989.
GeneID	3250204.
KEGG	gox:GOX0989.
PATRIC	32609754. VBIGluOxy81109_1249.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HOG000037638.
KO	K00942.
OMA	EWAEFAG.
ProtClustDB	PRK00300.
Enzyme and pathway databases
BioCyc	GOXY290633:GHB3-1029-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_GLUOX

Accession

Primary (citable) accession number: Q5FS85

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	March 1, 2005
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program