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Q5FRY0

- GCSP_GLUOX

UniProt

Q5FRY0 - GCSP_GLUOX

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciGOXY290633:GHB3-1095-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:GOX1097
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
ProteomesiUP000006375: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 951951Glycine dehydrogenase (decarboxylating)PRO_0000227105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi290633.GOX1097.

Structurei

3D structure databases

ProteinModelPortaliQ5FRY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FRY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPENLPVTTL WPAQTEDFSS RHIGPRPSEI GEMLRVVGAS SLDDLIDKTI
60 70 80 90 100
PAAILDRGDH GIGAALTEQD ALARLRQIAS RNQVLTSMIG QGYYDTVLPP
110 120 130 140 150
VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNFQTLVAD LTGLDIANAS
160 170 180 190 200
LLDEGTACAE AMALAQRVGK SKATAFFVDA DTHPQTIAVI RTRAEPLGWD
210 220 230 240 250
VVVGDPETDL DASSVFGALL SYPGSSGQVR DPRKVIAALH EKGAIAALAC
260 270 280 290 300
DPLALVLLES PGALGADIAI GSMQRYGVPM GAGGPHAAFM ATRDAFKRHM
310 320 330 340 350
PGRLVGVSRD SAGKPAYRLA LQTREQHIRR EKATSNICTA QALLAIIASM
360 370 380 390 400
YAVYHGPEGL KAIAARTHRM AAILSAGLKT LGATVETDVF FDTITVQAGA
410 420 430 440 450
SAPQVLARAV ASGINLRDAG DGRIGMSCDE TTTPETIRAV WAAFAGEGAD
460 470 480 490 500
LSAIEQALDV ADALPEGLSR TAPLLTHPVF HAHRSETDLL RYMRALADKD
510 520 530 540 550
LALDRTMIPL GSCTMKLNAT AEMIPITWPE FARIHPFAPA DQVQGYTELF
560 570 580 590 600
AYLERTLCAI SGYDAVSLQP NSGAQGEYAG LLAIRGYHRA RGDENRDVCL
610 620 630 640 650
IPASAHGTNP ASAQMAGMRV VVVACDENGN VDVEDLKAKI AQHDGRVAAI
660 670 680 690 700
MITYPSTHGV FEERIVEICE LVHAAGGQVY LDGANLNAQV GLARPGLYGA
710 720 730 740 750
DVSHFNLHKT FCIPHGGGGP GMGPIGVGKH LAPYLPGRHG IAVSAAPFGS
760 770 780 790 800
ASILPISAAY IMMMGDEGLR QATTMAILNA NYIASRLEGH YPVLYRGTNG
810 820 830 840 850
FTAHECIVDL RSLKDAVGVT VDDIAKRLID HGFHAPTVSF PVAGTFMIEP
860 870 880 890 900
TESEGKGELD RFCDAMIAIR AEIAEVEAGR VGMEDSPLRF APHTTADLAG
910 920 930 940 950
DWERSYSREA GCFPGGVDTA KYWSPVGRLD NAWGDRNLVC SCPDISTYVE

G
Length:951
Mass (Da):101,236
Last modified:March 1, 2005 - v1
Checksum:i66D2E6842A394192
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000009 Genomic DNA. Translation: AAW60866.1.
RefSeqiYP_191522.1. NC_006677.1.

Genome annotation databases

EnsemblBacteriaiAAW60866; AAW60866; GOX1097.
GeneIDi3249672.
KEGGigox:GOX1097.
PATRICi32609982. VBIGluOxy81109_1360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000009 Genomic DNA. Translation: AAW60866.1 .
RefSeqi YP_191522.1. NC_006677.1.

3D structure databases

ProteinModelPortali Q5FRY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290633.GOX1097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW60866 ; AAW60866 ; GOX1097 .
GeneIDi 3249672.
KEGGi gox:GOX1097.
PATRICi 32609982. VBIGluOxy81109_1360.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci GOXY290633:GHB3-1095-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
    Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
    Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 621H.

Entry informationi

Entry nameiGCSP_GLUOX
AccessioniPrimary (citable) accession number: Q5FRY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2005
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3