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Q5FRY0

- GCSP_GLUOX

UniProt

Q5FRY0 - GCSP_GLUOX

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciGOXY290633:GHB3-1095-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:GOX1097
    OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
    Taxonomic identifieri290633 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
    ProteomesiUP000006375: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 951951Glycine dehydrogenase (decarboxylating)PRO_0000227105Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi290633.GOX1097.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FRY0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5FRY0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPENLPVTTL WPAQTEDFSS RHIGPRPSEI GEMLRVVGAS SLDDLIDKTI    50
    PAAILDRGDH GIGAALTEQD ALARLRQIAS RNQVLTSMIG QGYYDTVLPP 100
    VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNFQTLVAD LTGLDIANAS 150
    LLDEGTACAE AMALAQRVGK SKATAFFVDA DTHPQTIAVI RTRAEPLGWD 200
    VVVGDPETDL DASSVFGALL SYPGSSGQVR DPRKVIAALH EKGAIAALAC 250
    DPLALVLLES PGALGADIAI GSMQRYGVPM GAGGPHAAFM ATRDAFKRHM 300
    PGRLVGVSRD SAGKPAYRLA LQTREQHIRR EKATSNICTA QALLAIIASM 350
    YAVYHGPEGL KAIAARTHRM AAILSAGLKT LGATVETDVF FDTITVQAGA 400
    SAPQVLARAV ASGINLRDAG DGRIGMSCDE TTTPETIRAV WAAFAGEGAD 450
    LSAIEQALDV ADALPEGLSR TAPLLTHPVF HAHRSETDLL RYMRALADKD 500
    LALDRTMIPL GSCTMKLNAT AEMIPITWPE FARIHPFAPA DQVQGYTELF 550
    AYLERTLCAI SGYDAVSLQP NSGAQGEYAG LLAIRGYHRA RGDENRDVCL 600
    IPASAHGTNP ASAQMAGMRV VVVACDENGN VDVEDLKAKI AQHDGRVAAI 650
    MITYPSTHGV FEERIVEICE LVHAAGGQVY LDGANLNAQV GLARPGLYGA 700
    DVSHFNLHKT FCIPHGGGGP GMGPIGVGKH LAPYLPGRHG IAVSAAPFGS 750
    ASILPISAAY IMMMGDEGLR QATTMAILNA NYIASRLEGH YPVLYRGTNG 800
    FTAHECIVDL RSLKDAVGVT VDDIAKRLID HGFHAPTVSF PVAGTFMIEP 850
    TESEGKGELD RFCDAMIAIR AEIAEVEAGR VGMEDSPLRF APHTTADLAG 900
    DWERSYSREA GCFPGGVDTA KYWSPVGRLD NAWGDRNLVC SCPDISTYVE 950
    G 951
    Length:951
    Mass (Da):101,236
    Last modified:March 1, 2005 - v1
    Checksum:i66D2E6842A394192
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000009 Genomic DNA. Translation: AAW60866.1.
    RefSeqiYP_191522.1. NC_006677.1.

    Genome annotation databases

    EnsemblBacteriaiAAW60866; AAW60866; GOX1097.
    GeneIDi3249672.
    KEGGigox:GOX1097.
    PATRICi32609982. VBIGluOxy81109_1360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000009 Genomic DNA. Translation: AAW60866.1 .
    RefSeqi YP_191522.1. NC_006677.1.

    3D structure databases

    ProteinModelPortali Q5FRY0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290633.GOX1097.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW60866 ; AAW60866 ; GOX1097 .
    GeneIDi 3249672.
    KEGGi gox:GOX1097.
    PATRICi 32609982. VBIGluOxy81109_1360.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci GOXY290633:GHB3-1095-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
      Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
      Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 621H.

    Entry informationi

    Entry nameiGCSP_GLUOX
    AccessioniPrimary (citable) accession number: Q5FRY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3