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Q5FRY0 (GCSP_GLUOX) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:GOX1097
OrganismGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) [Complete proteome] [HAMAP]
Taxonomic identifier290633 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter

Protein attributes

Sequence length951 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 951951Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227105

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5FRY0 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 66D2E6842A394192

FASTA951101,236
        10         20         30         40         50         60 
MPENLPVTTL WPAQTEDFSS RHIGPRPSEI GEMLRVVGAS SLDDLIDKTI PAAILDRGDH 

        70         80         90        100        110        120 
GIGAALTEQD ALARLRQIAS RNQVLTSMIG QGYYDTVLPP VIQRNILENP AWYTAYTPYQ 

       130        140        150        160        170        180 
PEISQGRLEA LLNFQTLVAD LTGLDIANAS LLDEGTACAE AMALAQRVGK SKATAFFVDA 

       190        200        210        220        230        240 
DTHPQTIAVI RTRAEPLGWD VVVGDPETDL DASSVFGALL SYPGSSGQVR DPRKVIAALH 

       250        260        270        280        290        300 
EKGAIAALAC DPLALVLLES PGALGADIAI GSMQRYGVPM GAGGPHAAFM ATRDAFKRHM 

       310        320        330        340        350        360 
PGRLVGVSRD SAGKPAYRLA LQTREQHIRR EKATSNICTA QALLAIIASM YAVYHGPEGL 

       370        380        390        400        410        420 
KAIAARTHRM AAILSAGLKT LGATVETDVF FDTITVQAGA SAPQVLARAV ASGINLRDAG 

       430        440        450        460        470        480 
DGRIGMSCDE TTTPETIRAV WAAFAGEGAD LSAIEQALDV ADALPEGLSR TAPLLTHPVF 

       490        500        510        520        530        540 
HAHRSETDLL RYMRALADKD LALDRTMIPL GSCTMKLNAT AEMIPITWPE FARIHPFAPA 

       550        560        570        580        590        600 
DQVQGYTELF AYLERTLCAI SGYDAVSLQP NSGAQGEYAG LLAIRGYHRA RGDENRDVCL 

       610        620        630        640        650        660 
IPASAHGTNP ASAQMAGMRV VVVACDENGN VDVEDLKAKI AQHDGRVAAI MITYPSTHGV 

       670        680        690        700        710        720 
FEERIVEICE LVHAAGGQVY LDGANLNAQV GLARPGLYGA DVSHFNLHKT FCIPHGGGGP 

       730        740        750        760        770        780 
GMGPIGVGKH LAPYLPGRHG IAVSAAPFGS ASILPISAAY IMMMGDEGLR QATTMAILNA 

       790        800        810        820        830        840 
NYIASRLEGH YPVLYRGTNG FTAHECIVDL RSLKDAVGVT VDDIAKRLID HGFHAPTVSF 

       850        860        870        880        890        900 
PVAGTFMIEP TESEGKGELD RFCDAMIAIR AEIAEVEAGR VGMEDSPLRF APHTTADLAG 

       910        920        930        940        950 
DWERSYSREA GCFPGGVDTA KYWSPVGRLD NAWGDRNLVC SCPDISTYVE G 

« Hide

References

[1]"Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 621H.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000009 Genomic DNA. Translation: AAW60866.1.
RefSeqYP_191522.1. NC_006677.1.

3D structure databases

ProteinModelPortalQ5FRY0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290633.GOX1097.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW60866; AAW60866; GOX1097.
GeneID3249672.
KEGGgox:GOX1097.
PATRIC32609982. VBIGluOxy81109_1360.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycGOXY290633:GHB3-1095-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_GLUOX
AccessionPrimary (citable) accession number: Q5FRY0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families