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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei162UniRule annotation1
Active sitei188UniRule annotation1
Active sitei287UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:GOX1555
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
Proteomesi
  • UP000006375 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002254621 – 351Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi290633.GOX1555.

Structurei

3D structure databases

ProteinModelPortaliQ5FQQ0.
SMRiQ5FQQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 125Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini151 – 345CheB-type methylesteraseUniRule annotationAdd BLAST195

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.
OMAiYGMPMAV.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FQQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGARPLTVV VVDDSLTTRA LIAAALRRDP RVKIVGTAGT PFEARDLIVR
60 70 80 90 100
LNPDVLTLDF EMPSMNGLQF LEKIMRLRPM PVVMVSGHLS SHRGLVEQSL
110 120 130 140 150
RMGAAEWYSK TTTANGEDPF AGLGDAIVRA AAMKQQAPVP VATDSANRTV
160 170 180 190 200
PKIGTVVGIG ASTGGVEALT DVLGHFPVAC PPTVIVQHMP RQFSESFARR
210 220 230 240 250
LDRIVKPEVR LAEEGDMLKP GTVYVASGGE RHLRVRCGAR SGEYVCQLVA
260 270 280 290 300
APPVNGHRPS VDELFYSLAT TVGKNAVGVI LTGMECDGAQ GLLAMRHAGA
310 320 330 340 350
STIGQDRASS VIYGMPRAAY ELGAVETQLP LSAIGPAILN LCERRSLETY

P
Length:351
Mass (Da):37,388
Last modified:March 1, 2005 - v1
Checksum:iB6F76C0DD3EAFB0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000009 Genomic DNA. Translation: AAW61296.1.
RefSeqiWP_011253081.1. NC_006677.1.

Genome annotation databases

EnsemblBacteriaiAAW61296; AAW61296; GOX1555.
GeneIDi29629138.
KEGGigox:GOX1555.

Similar proteinsi

Entry informationi

Entry nameiCHEB_GLUOX
AccessioniPrimary (citable) accession number: Q5FQQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2005
Last modified: November 22, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome