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Q5FQ48

- SYS_GLUOX

UniProt

Q5FQ48 - SYS_GLUOX

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Protein
Serine--tRNA ligase
Gene
serS, GOX1759
Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) By similarity.UniRule annotation

Catalytic activityi

ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).UniRule annotation
ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei283 – 2831Serine By similarity
Binding sitei381 – 3811Serine By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi260 – 2623ATP By similarity
Nucleotide bindingi347 – 3504ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. serine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. selenocysteine biosynthetic process Source: UniProtKB-HAMAP
  2. selenocysteinyl-tRNA(Sec) biosynthetic process Source: UniProtKB-UniPathway
  3. seryl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGOXY290633:GHB3-1757-MONOMER.
UniPathwayiUPA00906; UER00895.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine--tRNA ligase (EC:6.1.1.11)
Alternative name(s):
Seryl-tRNA synthetase
Short name:
SerRS
Seryl-tRNA(Ser/Sec) synthetase
Gene namesi
Name:serS
Ordered Locus Names:GOX1759
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
ProteomesiUP000006375: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Serine--tRNA ligaseUniRule annotation
PRO_0000122055Add
BLAST

Interactioni

Subunit structurei

Homodimer. The tRNA molecule binds across the dimer By similarity.

Protein-protein interaction databases

STRINGi290633.GOX1759.

Structurei

3D structure databases

ProteinModelPortaliQ5FQ48.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni229 – 2313Serine binding By similarity

Domaini

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0172.
HOGENOMiHOG000035938.
KOiK01875.
OMAiAIAMSVP.
OrthoDBiEOG61KBH9.

Family and domain databases

Gene3Di1.10.287.40. 1 hit.
HAMAPiMF_00176. Ser_tRNA_synth_type1.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR002317. Ser-tRNA-ligase_type_1.
IPR015866. Ser-tRNA-synth_1_N.
IPR010978. tRNA-bd_arm.
[Graphical view]
PANTHERiPTHR11778. PTHR11778. 1 hit.
PfamiPF02403. Seryl_tRNA_N. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFiPIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
PRINTSiPR00981. TRNASYNTHSER.
SUPFAMiSSF46589. SSF46589. 1 hit.
TIGRFAMsiTIGR00414. serS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FQ48-1 [UniParc]FASTAAdd to Basket

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MHDLKALRAD PAAFDAALAR RGLSPVGQQL VSDDEGRRAA LAALQEAQGA    50
RKALAKEIGL LKRQKLDTAE IEAKAVALRD QIAGLEERAN TIQTRIDDVL 100
KSLPNCLDAS VPDGKGEDEN VVVHVRGEKR EFAFEAKQHF ELGEALGLMD 150
FPTAAKLSGT RFVVLRGALA RLERALGQFM LDTHTTEFGY SETSVPLLVN 200
DDAMYGTDKL PKFAEDSFRT EDGRWLIPTA EVPLTASVMG EILPADALPI 250
RMTALSQCFR SEAGSAGRDV RGMLRQHQFT KCELVSVVKP EDSDAEHERM 300
TQAAETVLER LGITFRRMLL CAGDTGFGAA KTFDLEAWLP GQKAWREISS 350
CSNTRDFQAR RMNARYRAEN GPAFVNTLNG SGLAVGRTMI AVMETYQNED 400
GSIDIPEVLR PYMGGLNRIG 420
Length:420
Mass (Da):46,055
Last modified:March 1, 2005 - v1
Checksum:i988A253829198B49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000009 Genomic DNA. Translation: AAW61498.1.
RefSeqiYP_192154.1. NC_006677.1.

Genome annotation databases

EnsemblBacteriaiAAW61498; AAW61498; GOX1759.
GeneIDi3250023.
KEGGigox:GOX1759.
PATRICi32611404. VBIGluOxy81109_2041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000009 Genomic DNA. Translation: AAW61498.1 .
RefSeqi YP_192154.1. NC_006677.1.

3D structure databases

ProteinModelPortali Q5FQ48.
ModBasei Search...

Protein-protein interaction databases

STRINGi 290633.GOX1759.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW61498 ; AAW61498 ; GOX1759 .
GeneIDi 3250023.
KEGGi gox:GOX1759.
PATRICi 32611404. VBIGluOxy81109_2041.

Phylogenomic databases

eggNOGi COG0172.
HOGENOMi HOG000035938.
KOi K01875.
OMAi AIAMSVP.
OrthoDBi EOG61KBH9.

Enzyme and pathway databases

UniPathwayi UPA00906 ; UER00895 .
BioCyci GOXY290633:GHB3-1757-MONOMER.

Family and domain databases

Gene3Di 1.10.287.40. 1 hit.
HAMAPi MF_00176. Ser_tRNA_synth_type1.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR002317. Ser-tRNA-ligase_type_1.
IPR015866. Ser-tRNA-synth_1_N.
IPR010978. tRNA-bd_arm.
[Graphical view ]
PANTHERi PTHR11778. PTHR11778. 1 hit.
Pfami PF02403. Seryl_tRNA_N. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view ]
PIRSFi PIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
PRINTSi PR00981. TRNASYNTHSER.
SUPFAMi SSF46589. SSF46589. 1 hit.
TIGRFAMsi TIGR00414. serS. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
    Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
    Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 621H.

Entry informationi

Entry nameiSYS_GLUOX
AccessioniPrimary (citable) accession number: Q5FQ48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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