ID   Q5FPD7_GLUOX            Unreviewed;       829 AA.
AC   Q5FPD7;
DT   01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2005, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=Adenylate cyclase {ECO:0000313|EMBL:AAW61759.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:AAW61759.1};
GN   OrderedLocusNames=GOX2023 {ECO:0000313|EMBL:AAW61759.1};
OS   Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Gluconobacter.
OX   NCBI_TaxID=290633 {ECO:0000313|EMBL:AAW61759.1, ECO:0000313|Proteomes:UP000006375};
RN   [1] {ECO:0000313|EMBL:AAW61759.1, ECO:0000313|Proteomes:UP000006375}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=621H {ECO:0000313|EMBL:AAW61759.1,
RC   ECO:0000313|Proteomes:UP000006375};
RX   PubMed=15665824; DOI=10.1038/nbt1062;
RA   Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F.,
RA   Ehrenreich A., Gottschalk G., Deppenmeier U.;
RT   "Complete genome sequence of the acetic acid bacterium Gluconobacter
RT   oxydans.";
RL   Nat. Biotechnol. 23:195-200(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP000009; AAW61759.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5FPD7; -.
DR   STRING; 290633.GOX2023; -.
DR   KEGG; gox:GOX2023; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG2203; Bacteria.
DR   HOGENOM; CLU_347730_0_0_5; -.
DR   Proteomes; UP000006375; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR033479; dCache_1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR029151; Sensor-like_sf.
DR   Pfam; PF02743; dCache_1; 1.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF103190; Sensory domain-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Lyase {ECO:0000313|EMBL:AAW61759.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006375};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          657..781
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   829 AA;  90749 MW;  220D5E73467A78B9 CRC64;
     MRGRPLTGLC GNSKLRTCRR VSVHGCGLQS GNSRRILAYR GSTALFRDPV SVRSERTLSA
     AEIVDPTQSP ASDRRRIFQI LGPLVGVLLV IAAITGISLH NYQTTRKGAI SLSNDLLRSQ
     QRYVTQEVSD YLAPASIGAL IAQDMFRDPL TNATPDTFML YGRSILTHTP QVDSFYIAND
     QGQFWMITRH GQDGFEQTHF QTDDGKQVYH HVYTDKDGNV TGESSDPAEG YNVVTRPWFA
     KAVKHQNDPE RQLHWTDPYA YISTHQFIIT ASLAFDGHEG HKSVFAINIS LNQLTSFLNK
     LQVGRSGQAV IVDMHGRIIA GHNVAAGQDP KTFDPGNVFL DPKTQPVFIH ALNRFRIKGP
     GTGVVQARGK NYVTIASELP FVHRHWVLLL NAPESDFADF AQTARRQNIG FSLLVVGLAS
     VLALALVAQG RHVERLRKRL QRGRDQVKAE NASLLEIAST PDLFDPAHEV PILTEALTAR
     TSARRASLWR LLPDGDRLLC EDAFDPSRDV HSTGVEISRR DNGKLFEALD EGHTLSIADA
     SQDERTQTFQ RVIMRAVGAN TLLFQPVRNA HKTVGAIVLE DPGQPETMEH IIAIVGSIVA
     LRFAKPFDAA AGEGHSGLAI PTEKHDTRFD EGFLLEPSAT AGEPVAAGVY PQVPVMVISF
     VDPYAPDRDS IARAMNVIRT LSLEIQKIAR DSGLFSVQIV SNRLVLVGGC SQTPDPSAAV
     RLADAAVSIR EACLSSLAAA DLDPVFRIGM DVGSVMASEL GEGPSVFNIW GDALNGAELL
     TGSSPDAGTI QVSEQAYMIL REHFLFRERG MFYLPHSGIT RSFILAGRR
//