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Protein

Alanine racemase

Gene

GOX2061

Organism
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (GOX2061)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei143 – 1431SubstrateUniRule annotation
Active sitei260 – 2601Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei308 – 3081Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGOXY290633:GHB3-2059-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:GOX2061Imported
OrganismiGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)Imported
Taxonomic identifieri290633 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeGluconobacter
ProteomesiUP000006375 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi290633.GOX2061.

Structurei

3D structure databases

ProteinModelPortaliQ5FP99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031445.
KOiK01775.
OMAiDAGTISY.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FP99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTVFQDAAS ARAGAWLGVS LRAIAENYNL VAALGAGAEC AVVVKADAYG
60 70 80 90 100
LSADRVAPVL AARGAGTFFV AHLDEGIALR AILPEVRIFV LHGFMPGCEG
110 120 130 140 150
SMQAHNLFPV LNDLEQVRSW QRLCREKGCA FPAALQFDTG MSRFGLSDQD
160 170 180 190 200
LEDRSVFEGL NLQLVMSHLA CADTPDNPAN AIQRKRFVEM AAGFPGVPRS
210 220 230 240 250
LAASSGIFLG PDYHFELIRP GAALYGIAPF EGSRVLNPVV SLDARIVQIR
260 270 280 290 300
TVQAGDRVGY GLGWTATKPT RIATLGLGYA DGFFRAQAGH GAVWYGQTRL
310 320 330 340 350
PVIGRVSMDS ISVDLTDAPA GLKAGDVLSV LGPAQDVDAL ARSAGTIGYE
360
VLTALGSRFH RVYVSDD
Length:367
Mass (Da):38,950
Last modified:March 1, 2005 - v1
Checksum:iCF4A25B95371512D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000009 Genomic DNA. Translation: AAW61797.1.
RefSeqiWP_011253574.1. NC_006677.1.
YP_192453.1. NC_006677.1.

Genome annotation databases

EnsemblBacteriaiAAW61797; AAW61797; GOX2061.
KEGGigox:GOX2061.
PATRICi32612054. VBIGluOxy81109_2363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000009 Genomic DNA. Translation: AAW61797.1.
RefSeqiWP_011253574.1. NC_006677.1.
YP_192453.1. NC_006677.1.

3D structure databases

ProteinModelPortaliQ5FP99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290633.GOX2061.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW61797; AAW61797; GOX2061.
KEGGigox:GOX2061.
PATRICi32612054. VBIGluOxy81109_2363.

Phylogenomic databases

HOGENOMiHOG000031445.
KOiK01775.
OMAiDAGTISY.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciGOXY290633:GHB3-2059-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
    Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
    Nat. Biotechnol. 23:195-200(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 621HImported.

Entry informationi

Entry nameiQ5FP99_GLUOX
AccessioniPrimary (citable) accession number: Q5FP99
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2005
Last sequence update: March 1, 2005
Last modified: June 24, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.