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Q5FP70 (GLPK_GLUOX) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:GOX2090
OrganismGluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) [Complete proteome] [HAMAP]
Taxonomic identifier290633 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconobacter

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Glycerol kinase HAMAP MF_00186
PRO_1000020732

Regions

Nucleotide binding410 – 4145ATP By similarity

Sites

Binding site141Substrate By similarity
Binding site181ATP By similarity
Binding site831Substrate By similarity
Binding site1351Substrate By similarity
Binding site2441Substrate By similarity
Binding site2661ATP By similarity
Binding site3091ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5FP70 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 61149A1DBC0DCC19

FASTA51256,559
        10         20         30         40         50         60 
MSKKDCILAI DQGTTSTRSI VFGKDAQALA ISRREFPQHY PELGWVEHDV EDIWRDVLAT 

        70         80         90        100        110        120 
ARETIEEVGG PERIAALGIT NQRETIVIWD RETGRAIHRA LVWQDRRTAH ECNLLRQQGK 

       130        140        150        160        170        180 
EAMVREKTGL LLDPYFSASK IAWLLDHVPD ARRRAEAGEL AAGTIDSFLL WRLTGGKRHA 

       190        200        210        220        230        240 
TDITNACRTS LFNIHTQEWD EELLKLFNVP RALLPEVCDN SSDFGETEAK LFGEKIAIGG 

       250        260        270        280        290        300 
MAGDQHAAVI GQACFHEGMA KATYGTGCFM LLNTGEKPIM SNNRLLTTIA YRIGGKTFYA 

       310        320        330        340        350        360 
LEGSIFVAGA GIKWLRDGLK LITHASQTDD MATRIPDSHG VYMVPAFVGL GAPHWDPDSR 

       370        380        390        400        410        420 
GLICGLTLGS TQAHIARAML ESVAYQTYDL IRAMREDGAM RTSILRIDGG MAVNDWFAQF 

       430        440        450        460        470        480 
LSSMLKAEVE RPVNIETTAL GAAFLAGLQV GLWKSLDEVT ATWKQERVFA PKMDPAQRRI 

       490        500        510 
MIDGWHDAVR RTLTPSAPVA HSSVETTASQ AA

« Hide

References

[1]"Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans."
Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U.
Nat. Biotechnol. 23:195-200(2005) [PubMed: 15665824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 621H.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000009 Genomic DNA. Translation: AAW61826.1.
RefSeqYP_192482.1. NC_006677.1.

3D structure databases

HSSPHSSP built from PDB template 1GLC based on UniProtKB P0A6F3.
ProteinModelPortalQ5FP70.
SMRQ5FP70. Positions 3-494.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3248272.
GenomeReviewsGene locus GOX2090 in contig CP000009_GR.
KEGGgox:GOX2090.
NMPDRfig|290633.1.peg.2027.
PATRIC32612120. VBIGluOxy81109_2396.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG511469.
OMACYQTRDL.
ProtClustDBCLSK936619.

Enzyme and pathway databases

BioCycGOXY290633:GOX2090-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_GLUOX
AccessionPrimary (citable) accession number: Q5FP70
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2005
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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