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Q5FMX8 (RTPR_LACAC) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Short name=RTPR
EC=1.17.4.2
Gene names
Name:rtpR
Ordered Locus Names:LBA0041
OrganismLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) [Complete proteome] [HAMAP]
Taxonomic identifier272621 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length744 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactor

Adenosylcobalamin By similarity.

Enzyme regulation

Allosterically regulated by ATP and dNTP By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the class II ribonucleoside-triphosphate reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 744744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase
PRO_0000326536

Regions

Region148 – 15912Effector region-1 By similarity
Region169 – 318150Effector region-2 By similarity
Region570 – 63162Adenosylcobalamin-binding-1 By similarity
Region690 – 72940Adenosylcobalamin-binding-2 By similarity

Sites

Active site4131 By similarity
Active site4151 By similarity

Amino acid modifications

Disulfide bond120 ↔ 424Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5FMX8 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 4D3564C885BB1EB0

FASTA74483,521
        10         20         30         40         50         60 
MSSTRIELDQ DFIDQVKHEI KPHWGELGWV TYKRTYARWL PEKNRSENWD ETVKRVIEGN 

        70         80         90        100        110        120 
VNLDPRLQGT PSEEVINELT NEAKQLFRLT YGLSATPSGR NLWISGTDYQ KRTGDSLNNC 

       130        140        150        160        170        180 
WFIAIRPQEY GDSHIVPTYI DKREKAVSMP FSFLFDQLMK GGGVGFSVVN SNIKQIPKVD 

       190        200        210        220        230        240 
NKIDLTVVIN KSSKSHDASI KVGAVDKDEW EKQNPDHDDI IYYRLPDTRE GWVLANARLI 

       250        260        270        280        290        300 
DMHFNNTNPD QKTKLVLDIS DIRPYGAKIH GFGGTASGPM PLVEMFIDIN NVINARVGKN 

       310        320        330        340        350        360 
LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSNDDQDFIK MKQDKEKLYH HRWASNNSVA 

       370        380        390        400        410        420 
INSKFNNYGP IADGILHNGE PGIVNLDLSR NYGRIVDGYQ PGIDDDVEGT NPCGEISLAN 

       430        440        450        460        470        480 
GEPCNLFEVF PYTAEKQGWN LKEAFTLATR FAKRVTFSHY DWEVSRKIIQ KNRRIGVSMS 

       490        500        510        520        530        540 
GIQDWLLNDL GHRVVTGFED AVDEQSGEKI KKPIYDPKGI EMVDSLYKAV ITADKAYSEE 

       550        560        570        580        590        600 
LGVNPSIKHT TVKPSGTVAK LAGVSEGMHF HYAGYLIQRI RFQASDPLLP ALKECGYHTE 

       610        620        630        640        650        660 
PDIYTKNTIC VEFPLRAAHA DSKNFASAGT VSIEEQFATQ AFLQTYWSDN AVSCTITFQS 

       670        680        690        700        710        720 
DENDEIAPLL RQYRHTIKST SLLPYYGGSL KQAPKEPINK KTYEERAALI TDDVEEVFTK 

       730        740 
QNDDQKGLEL VGQTDCEGGA CPIK 

« Hide

References

[1]"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM."
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000033 Genomic DNA. Translation: AAV41946.1.
RefSeqYP_192977.1. NC_006814.3.

3D structure databases

ProteinModelPortalQ5FMX8.
SMRQ5FMX8. Positions 6-729.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272621.LBA0041.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV41946; AAV41946; LBA0041.
GeneID3252771.
KEGGlac:LBA0041.
PATRIC22195128. VBILacAci7974_0039.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0209.
HOGENOMHOG000068540.
KOK00527.
OMAWISGTDY.
OrthoDBEOG68DCVH.
ProtClustDBCLSK936728.

Family and domain databases

InterProIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsTIGR02505. RTPR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRTPR_LACAC
AccessionPrimary (citable) accession number: Q5FMX8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2005
Last modified: November 13, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families