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Q5FMX8

- RTPR_LACAC

UniProt

Q5FMX8 - RTPR_LACAC

Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Enzyme regulationi

    Allosterically regulated by ATP and dNTP.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei413 – 4131By similarity
    Active sitei415 – 4151By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
    4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Short name:
    RTPR
    Gene namesi
    Name:rtpR
    Ordered Locus Names:LBA0041
    OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
    Taxonomic identifieri272621 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000006381: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 744744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326536Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi120 ↔ 424Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi272621.LBA0041.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FMX8.
    SMRiQ5FMX8. Positions 6-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni148 – 15912Effector region-1By similarityAdd
    BLAST
    Regioni169 – 318150Effector region-2By similarityAdd
    BLAST
    Regioni570 – 63162Adenosylcobalamin-binding-1By similarityAdd
    BLAST
    Regioni690 – 72940Adenosylcobalamin-binding-2By similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0209.
    HOGENOMiHOG000068540.
    KOiK00527.
    OMAiDSLNNCW.
    OrthoDBiEOG68DCVH.

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02505. RTPR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5FMX8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTRIELDQ DFIDQVKHEI KPHWGELGWV TYKRTYARWL PEKNRSENWD    50
    ETVKRVIEGN VNLDPRLQGT PSEEVINELT NEAKQLFRLT YGLSATPSGR 100
    NLWISGTDYQ KRTGDSLNNC WFIAIRPQEY GDSHIVPTYI DKREKAVSMP 150
    FSFLFDQLMK GGGVGFSVVN SNIKQIPKVD NKIDLTVVIN KSSKSHDASI 200
    KVGAVDKDEW EKQNPDHDDI IYYRLPDTRE GWVLANARLI DMHFNNTNPD 250
    QKTKLVLDIS DIRPYGAKIH GFGGTASGPM PLVEMFIDIN NVINARVGKN 300
    LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSNDDQDFIK MKQDKEKLYH 350
    HRWASNNSVA INSKFNNYGP IADGILHNGE PGIVNLDLSR NYGRIVDGYQ 400
    PGIDDDVEGT NPCGEISLAN GEPCNLFEVF PYTAEKQGWN LKEAFTLATR 450
    FAKRVTFSHY DWEVSRKIIQ KNRRIGVSMS GIQDWLLNDL GHRVVTGFED 500
    AVDEQSGEKI KKPIYDPKGI EMVDSLYKAV ITADKAYSEE LGVNPSIKHT 550
    TVKPSGTVAK LAGVSEGMHF HYAGYLIQRI RFQASDPLLP ALKECGYHTE 600
    PDIYTKNTIC VEFPLRAAHA DSKNFASAGT VSIEEQFATQ AFLQTYWSDN 650
    AVSCTITFQS DENDEIAPLL RQYRHTIKST SLLPYYGGSL KQAPKEPINK 700
    KTYEERAALI TDDVEEVFTK QNDDQKGLEL VGQTDCEGGA CPIK 744
    Length:744
    Mass (Da):83,521
    Last modified:March 1, 2005 - v1
    Checksum:i4D3564C885BB1EB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000033 Genomic DNA. Translation: AAV41946.1.
    RefSeqiYP_192977.1. NC_006814.3.

    Genome annotation databases

    EnsemblBacteriaiAAV41946; AAV41946; LBA0041.
    GeneIDi3252771.
    KEGGilac:LBA0041.
    PATRICi22195128. VBILacAci7974_0039.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000033 Genomic DNA. Translation: AAV41946.1 .
    RefSeqi YP_192977.1. NC_006814.3.

    3D structure databases

    ProteinModelPortali Q5FMX8.
    SMRi Q5FMX8. Positions 6-729.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272621.LBA0041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV41946 ; AAV41946 ; LBA0041 .
    GeneIDi 3252771.
    KEGGi lac:LBA0041.
    PATRICi 22195128. VBILacAci7974_0039.

    Phylogenomic databases

    eggNOGi COG0209.
    HOGENOMi HOG000068540.
    KOi K00527.
    OMAi DSLNNCW.
    OrthoDBi EOG68DCVH.

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    IPR013345. RTP_Rdtase_AdoCbl-dep.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02505. RTPR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700396 / NCK56 / N2 / NCFM.

    Entry informationi

    Entry nameiRTPR_LACAC
    AccessioniPrimary (citable) accession number: Q5FMX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3