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Q5FMX8

- RTPR_LACAC

UniProt

Q5FMX8 - RTPR_LACAC

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Protein

Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Adenosylcobalamin.By similarity

Enzyme regulationi

Allosterically regulated by ATP and dNTP.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei413 – 4131By similarity
Active sitei415 – 4151By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. nucleotide binding Source: InterPro
  3. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: InterPro
  4. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:LBA0041
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006381: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 744744Adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 424Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272621.LBA0041.

Structurei

3D structure databases

ProteinModelPortaliQ5FMX8.
SMRiQ5FMX8. Positions 6-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni148 – 15912Effector region-1By similarityAdd
BLAST
Regioni169 – 318150Effector region-2By similarityAdd
BLAST
Regioni570 – 63162Adenosylcobalamin-binding-1By similarityAdd
BLAST
Regioni690 – 72940Adenosylcobalamin-binding-2By similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0209.
HOGENOMiHOG000068540.
KOiK00527.
OMAiDSLNNCW.
OrthoDBiEOG68DCVH.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02505. RTPR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FMX8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSTRIELDQ DFIDQVKHEI KPHWGELGWV TYKRTYARWL PEKNRSENWD
60 70 80 90 100
ETVKRVIEGN VNLDPRLQGT PSEEVINELT NEAKQLFRLT YGLSATPSGR
110 120 130 140 150
NLWISGTDYQ KRTGDSLNNC WFIAIRPQEY GDSHIVPTYI DKREKAVSMP
160 170 180 190 200
FSFLFDQLMK GGGVGFSVVN SNIKQIPKVD NKIDLTVVIN KSSKSHDASI
210 220 230 240 250
KVGAVDKDEW EKQNPDHDDI IYYRLPDTRE GWVLANARLI DMHFNNTNPD
260 270 280 290 300
QKTKLVLDIS DIRPYGAKIH GFGGTASGPM PLVEMFIDIN NVINARVGKN
310 320 330 340 350
LTAVDATDIC NLIGKTVVAG NVRRSAELAL GSNDDQDFIK MKQDKEKLYH
360 370 380 390 400
HRWASNNSVA INSKFNNYGP IADGILHNGE PGIVNLDLSR NYGRIVDGYQ
410 420 430 440 450
PGIDDDVEGT NPCGEISLAN GEPCNLFEVF PYTAEKQGWN LKEAFTLATR
460 470 480 490 500
FAKRVTFSHY DWEVSRKIIQ KNRRIGVSMS GIQDWLLNDL GHRVVTGFED
510 520 530 540 550
AVDEQSGEKI KKPIYDPKGI EMVDSLYKAV ITADKAYSEE LGVNPSIKHT
560 570 580 590 600
TVKPSGTVAK LAGVSEGMHF HYAGYLIQRI RFQASDPLLP ALKECGYHTE
610 620 630 640 650
PDIYTKNTIC VEFPLRAAHA DSKNFASAGT VSIEEQFATQ AFLQTYWSDN
660 670 680 690 700
AVSCTITFQS DENDEIAPLL RQYRHTIKST SLLPYYGGSL KQAPKEPINK
710 720 730 740
KTYEERAALI TDDVEEVFTK QNDDQKGLEL VGQTDCEGGA CPIK
Length:744
Mass (Da):83,521
Last modified:March 1, 2005 - v1
Checksum:i4D3564C885BB1EB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000033 Genomic DNA. Translation: AAV41946.1.
RefSeqiYP_192977.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV41946; AAV41946; LBA0041.
GeneIDi3252771.
KEGGilac:LBA0041.
PATRICi22195128. VBILacAci7974_0039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000033 Genomic DNA. Translation: AAV41946.1 .
RefSeqi YP_192977.1. NC_006814.3.

3D structure databases

ProteinModelPortali Q5FMX8.
SMRi Q5FMX8. Positions 6-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272621.LBA0041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV41946 ; AAV41946 ; LBA0041 .
GeneIDi 3252771.
KEGGi lac:LBA0041.
PATRICi 22195128. VBILacAci7974_0039.

Phylogenomic databases

eggNOGi COG0209.
HOGENOMi HOG000068540.
KOi K00527.
OMAi DSLNNCW.
OrthoDBi EOG68DCVH.

Family and domain databases

InterProi IPR000788. RNR_lg_C.
IPR013345. RTP_Rdtase_AdoCbl-dep.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02505. RTPR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Entry informationi

Entry nameiRTPR_LACAC
AccessioniPrimary (citable) accession number: Q5FMX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2005
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3