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Q5FM02 (KTHY_LACAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidylate kinase

EC=2.7.4.9
Alternative name(s):
dTMP kinase
Gene names
Name:tmk
Ordered Locus Names:LBA0381
OrganismLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) [Complete proteome] [HAMAP]
Taxonomic identifier272621 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165

Catalytic activity

ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165

Sequence similarities

Belongs to the thymidylate kinase family.

Ontologies

Keywords
   Biological processNucleotide biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdTDP biosynthetic process

Inferred from electronic annotation. Source: InterPro

dTTP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Thymidylate kinase HAMAP-Rule MF_00165
PRO_0000155286

Regions

Nucleotide binding10 – 178ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q5FM02 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 15BA1231B347A63B

FASTA21624,300
        10         20         30         40         50         60 
MKGYFVSFEG PDGAGKSTVL KEVLAEIAPQ LKTQYLVTRE PGGSKIAEKI RDIILDPAND 

        70         80         90        100        110        120 
KMDPKTEALL YAAARSQHVE EIIKPAINEG KVVFSDRFVD SSLAYQGQGR DLGIAKVKQI 

       130        140        150        160        170        180 
NDFATDKLDP DLTFFLDIAP EIGLSRIKKL RPAQEDRLEQ EDIAFHQKVY EGFLKVIKMY 

       190        200        210 
PDRFVVINAT QPIDQVVKQV VTELKQRLPK TILENN 

« Hide

References

[1]"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM."
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000033 Genomic DNA. Translation: AAV42272.1.
RefSeqYP_193303.1. NC_006814.3.

3D structure databases

ProteinModelPortalQ5FM02.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272621.LBA0381.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV42272; AAV42272; LBA0381.
GeneID3252040.
KEGGlac:LBA0381.
PATRIC22195806. VBILacAci7974_0367.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0125.
HOGENOMHOG000229078.
KOK00943.
OMAMEAILFA.
OrthoDBEOG64JFSH.
ProtClustDBPRK00698.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00165. Thymidylate_kinase.
InterProIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00041. DTMP_kinase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKTHY_LACAC
AccessionPrimary (citable) accession number: Q5FM02
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2005
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families