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Q5FM02

- KTHY_LACAC

UniProt

Q5FM02 - KTHY_LACAC

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Protein
Thymidylate kinase
Gene
tmk, LBA0381
Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTDP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:LBA0381
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006381: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Thymidylate kinaseUniRule annotation
PRO_0000155286Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272621.LBA0381.

Structurei

3D structure databases

ProteinModelPortaliQ5FM02.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0125.
HOGENOMiHOG000229078.
KOiK00943.
OMAiEPGGCPI.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FM02-1 [UniParc]FASTAAdd to Basket

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MKGYFVSFEG PDGAGKSTVL KEVLAEIAPQ LKTQYLVTRE PGGSKIAEKI    50
RDIILDPAND KMDPKTEALL YAAARSQHVE EIIKPAINEG KVVFSDRFVD 100
SSLAYQGQGR DLGIAKVKQI NDFATDKLDP DLTFFLDIAP EIGLSRIKKL 150
RPAQEDRLEQ EDIAFHQKVY EGFLKVIKMY PDRFVVINAT QPIDQVVKQV 200
VTELKQRLPK TILENN 216
Length:216
Mass (Da):24,300
Last modified:March 1, 2005 - v1
Checksum:i15BA1231B347A63B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000033 Genomic DNA. Translation: AAV42272.1.
RefSeqiYP_193303.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV42272; AAV42272; LBA0381.
GeneIDi3252040.
KEGGilac:LBA0381.
PATRICi22195806. VBILacAci7974_0367.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000033 Genomic DNA. Translation: AAV42272.1 .
RefSeqi YP_193303.1. NC_006814.3.

3D structure databases

ProteinModelPortali Q5FM02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272621.LBA0381.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV42272 ; AAV42272 ; LBA0381 .
GeneIDi 3252040.
KEGGi lac:LBA0381.
PATRICi 22195806. VBILacAci7974_0367.

Phylogenomic databases

eggNOGi COG0125.
HOGENOMi HOG000229078.
KOi K00943.
OMAi EPGGCPI.
OrthoDBi EOG64JFSH.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00165. Thymidylate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR018094. Thymidylate_kinase.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Entry informationi

Entry nameiKTHY_LACAC
AccessioniPrimary (citable) accession number: Q5FM02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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