Q5FLF6 (RPIA_LACAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribose-5-phosphate isomerase A
EC=5.3.1.6

Alternative name(s):
Phosphoriboisomerase A
Short name=PRI

Gene names

Name:	rpiA
Ordered Locus Names:	LBA0588

Organism

Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) [Complete proteome] [HAMAP]

Taxonomic identifier

272621 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP MF_00170
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP MF_00170
Sequence similarities	Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt, non-oxidative branch Inferred from electronic annotation. Source: InterPro
Molecular function	ribose-5-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Ribose-5-phosphate isomerase A HAMAP MF_00170		PRO_0000158425

Sequences

	Sequence		Length	Mass (Da)
	Q5FLF6 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: FF0437E01F802FA6	FASTA	230	25,346
	10 20 30 40 50 60 MDKKEQDRLK KEAAEKAANM VQSGMILGVG TGSTVAFFID ALGKRKDEED LKLKAIVTTS 70 80 90 100 110 120 NRSKKQLESL GFEVSELADI DQADLTVDGS DRVADNLDGI KGGGGALTLE KNVAINSKKI 130 140 150 160 170 180 VWIVDESKLV HRLSGFPLPV EVLPISCEQN FRRFEQEGLK PQWRTDGDKR YITHYGNYII 190 200 210 220 230 DLAVDPIPAP HGLADYLDHT VGVVEHGLFL DMCDEVIIAH SDGTIEDKIK

References

[1]

"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM." Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R. Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005) [PubMed: 15671160] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000033 Genomic DNA. Translation: AAV42468.1.
RefSeq	YP_193499.1. NC_006814.3.
3D structure databases
ProteinModelPortal	Q5FLF6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3252540.
GenomeReviews	Gene locus LBA0588 in contig CP000033_GR.
KEGG	lac:LBA0588.
NMPDR	fig|272621.3.peg.353.
PATRIC	22196286. VBILacAci7974_0562.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG515603.
OMA	NLSLYVD.
ProtClustDB	PRK00702.
Enzyme and pathway databases
BioCyc	LACI272621:LBA0588-MONOMER.
Family and domain databases
HAMAP	MF_00170. Rib_5P_isom_A. [Tree]
InterPro	IPR004788. Ribose5P_isomerase_typA. IPR020672. Ribose5P_isomerase_typA_subgr. [Graphical view]
KO	K01807.
PANTHER	PTHR11934. RpiA. 1 hit.
Pfam	PF06026. Rib_5-P_isom_A. 1 hit. [Graphical view]
TIGRFAMs	TIGR00021. RpiA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RPIA_LACAC

Accession

Primary (citable) accession number: Q5FLF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	March 1, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program