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Q5FL98

- NADK_LACAC

UniProt

Q5FL98 - NADK_LACAC

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Protein

NAD kinase

Gene

nadK

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei45 – 451Proton acceptorUniRule annotation
Binding sitei147 – 1471NADUniRule annotation
Binding sitei149 – 1491NADUniRule annotation
Binding sitei184 – 1841NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi45 – 462NADUniRule annotation
Nucleotide bindingi121 – 1222NADUniRule annotation
Nucleotide bindingi160 – 1656NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciLACI272621:GJO8-1078-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:LBA0647
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006381: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267NAD kinasePRO_0000229646Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272621.LBA0647.

Structurei

3D structure databases

ProteinModelPortaliQ5FL98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000275803.
KOiK00858.
OMAiQWITIVP.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FL98-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVTIAHNNY DKTLKTVAYL KEILKKKNVV FDAKYPDVVI SVGGDGTLIN
60 70 80 90 100
AFHRYENQVD SVRFIGVHTG HLGFYTDWRN YDIDKMVDAL LLTDEAPAKY
110 120 130 140 150
PLLEIKLITE SGETKYHLAV NESAVKRVSH TLEADVYIND ELFENFRGDG
160 170 180 190 200
LCVSTPTGST AYSKSLGGAV IHPRLKALQM TEIASINNRV FRTLSAPIVI
210 220 230 240 250
APDQWITIVP NADHFVMTVD GARIDVRNAK KIEYRISHHS IQFDQFGHHH
260
FWSRVQDAFI GENNSND
Length:267
Mass (Da):30,161
Last modified:March 1, 2005 - v1
Checksum:i86E3D105806A8DB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV42526.1.
RefSeqiYP_193557.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV42526; AAV42526; LBA0647.
GeneIDi3252524.
KEGGilac:LBA0647.
PATRICi22196404. VBILacAci7974_0620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV42526.1 .
RefSeqi YP_193557.1. NC_006814.3.

3D structure databases

ProteinModelPortali Q5FL98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272621.LBA0647.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV42526 ; AAV42526 ; LBA0647 .
GeneIDi 3252524.
KEGGi lac:LBA0647.
PATRICi 22196404. VBILacAci7974_0620.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000275803.
KOi K00858.
OMAi QWITIVP.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci LACI272621:GJO8-1078-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Entry informationi

Entry nameiNADK_LACAC
AccessioniPrimary (citable) accession number: Q5FL98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2005
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3