ID   Q5FL96_LACAC            Unreviewed;       591 AA.
AC   Q5FL96;
DT   01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2005, sequence version 1.
DT   27-MAR-2024, entry version 87.
DE   SubName: Full=Myosin-crossreactive antigen {ECO:0000313|EMBL:AAV42528.1};
GN   OrderedLocusNames=LBA0649 {ECO:0000313|EMBL:AAV42528.1};
OS   Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=272621 {ECO:0000313|Proteomes:UP000006381};
RN   [1] {ECO:0000313|EMBL:AAV42528.1, ECO:0000313|Proteomes:UP000006381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700396 / NCK56 / N2 / NCFM
RC   {ECO:0000313|Proteomes:UP000006381};
RX   PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA   Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA   McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA   Hamrick A., Cano R., Klaenhammer T.R.;
RT   "Complete genome sequence of the probiotic lactic acid bacterium
RT   Lactobacillus acidophilus NCFM.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
RN   [2] {ECO:0007829|PDB:4IA5, ECO:0007829|PDB:4IA6}
RP   X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
RX   PubMed=23519674; DOI=10.1107/S0907444913000991;
RA   Volkov A., Khoshnevis S., Neumann P., Herrfurth C., Wohlwend D., Ficner R.,
RA   Feussner I.;
RT   "Crystal structure analysis of a fatty acid double-bond hydratase from
RT   Lactobacillus acidophilus.";
RL   Acta Crystallogr. D 69:648-657(2013).
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DR   EMBL; CP000033; AAV42528.1; -; Genomic_DNA.
DR   RefSeq; WP_011254216.1; NC_006814.3.
DR   RefSeq; YP_193559.1; NC_006814.3.
DR   PDB; 4IA5; X-ray; 2.22 A; A/B=1-591.
DR   PDB; 4IA6; X-ray; 1.80 A; A/B=1-591.
DR   PDBsum; 4IA5; -.
DR   PDBsum; 4IA6; -.
DR   AlphaFoldDB; Q5FL96; -.
DR   SMR; Q5FL96; -.
DR   STRING; 272621.LBA0649; -.
DR   GeneID; 56942284; -.
DR   KEGG; lac:LBA0649; -.
DR   PATRIC; fig|272621.13.peg.622; -.
DR   eggNOG; COG4716; Bacteria.
DR   HOGENOM; CLU_024043_2_0_9; -.
DR   OrthoDB; 4540221at2; -.
DR   BioCyc; LACI272621:G1G49-674-MONOMER; -.
DR   BRENDA; 4.2.1.53; 2846.
DR   Proteomes; UP000006381; Chromosome.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0050151; F:oleate hydratase activity; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 3.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR010354; Oleate_hydratase.
DR   PANTHER; PTHR37417; 67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970); 1.
DR   PANTHER; PTHR37417:SF3; MYOSIN-CROSSREACTIVE PROTEIN-RELATED; 1.
DR   Pfam; PF06100; MCRA; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4IA5, ECO:0007829|PDB:4IA6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006381}.
SQ   SEQUENCE   591 AA;  67617 MW;  9692FBA1EBC00C4D CRC64;
     MYYSNGNYEA FADPKKPAGV DKKSAYIIGS GLAGLSTAVF LVRDAQMKGE NIHILEELPV
     AGGSLDGADR PNAGFVVRGG REMENHFECL WDMYRSIPSL EVPGASYLDE YYWLDKEDPN
     SSNCRLIYNR GDRLPSDGQY GLGKCANEIV KLIMTPEKEI EGQTIEEFFS DEFFKTNFWT
     YWSTMFAFEK WHSLAEMRRY AMRFIHHIDG LPDFTALKFN KYNQYESMVK PLLAYLKDHG
     VQFEYDCHVK NVEVDHEGDS KIAKKIVMTQ NGKDKEIDLT HNDIVFVTNG SITESSTYGD
     QNTPAPITNA KGDSWKLWEN LAKQDPAFGH PDVFCENLPE RSWFVSATAT LENKKLAPYF
     ERLTKRSLYD GKVNTGGIIT IVDSNWELSF TIHRQPHFKS QNPDQIVVWI YALYSDTEGN
     YIKKRIVDCT GKEIAEELLY HLGVPESQIS ELASEENMNT VPVYMPYITS YFMPRRDGDR
     PDVVPEGSIN LAFIGNFAES PTRDTVFTTE YSVRTAMEAV YTLLNVDRGV PEVFDSIYDI
     RQLLRAMYYM SDKKKLADQD MPLPEKLAVK TGMRKIKKTW VEELLKEANL V
//