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Q5FL41

- POTA_LACAC

UniProt

Q5FL41 - POTA_LACAC

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Protein
Spermidine/putrescine import ATP-binding protein PotA
Gene
potA, LBA0709
Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system By similarity.

Catalytic activityi

ATP + H2O + polyamine(Out) = ADP + phosphate + polyamine(In).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. putrescine-importing ATPase activity Source: InterPro
  3. spermidine-importing ATPase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Spermidine/putrescine import ATP-binding protein PotA (EC:3.6.3.31)
    Gene namesi
    Name:potA
    Ordered Locus Names:LBA0709
    OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
    Taxonomic identifieri272621 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000006381: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 365365Spermidine/putrescine import ATP-binding protein PotA
    PRO_0000286226Add
    BLAST

    Interactioni

    Subunit structurei

    The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD) Reviewed prediction.

    Protein-protein interaction databases

    STRINGi272621.LBA0709.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FL41.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 235232ABC transporter
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3842.
    KOiK11072.
    OMAiYDEPVND.
    OrthoDBiEOG6T7N3V.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR017879. ABC_Sperm/Put_ATP-bd_PotA.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR008995. Mo/tungstate-bd_C_term_dom.
    IPR027417. P-loop_NTPase.
    IPR005893. Sp_pt_ABC_ATP-bd.
    IPR013611. Transp-assoc_OB_typ2.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    PF08402. TOBE_2. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF50331. SSF50331. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01187. potA. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51305. POTA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FL41-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIIKLKHIT KRYDDGFIAL KDINITIESG KFYSLLGPSG SGKSTILRII    50
    AGFTQPSSGQ VFFDGKDITD LDASKRHINT VFQNYALFPH LNVFENVAFG 100
    LKIKKKPLNE IRPAVKDALH MVRLDGYANR EISELSGGQQ QRVAIARAIV 150
    NEPKVLLLDE SLSALDKRLR KDMQFELRAI QKKLGITFIF VTHDQEEALS 200
    MSDEIFVLND GQIQQSGSPV AIYDEPVNDF VARFIGDSNI LPGRMIKDYV 250
    VEFANNKFRC ADGGIKSNEK VEVVIRPEDL DIVAPEKGKI VVTAQTQLFL 300
    GDHFEIKAID ANENEWLIHS TNGVKLGQRI GLFFDPEDIH VMRLNESQKD 350
    FDARIEKYEG DENED 365
    Length:365
    Mass (Da):41,156
    Last modified:March 1, 2005 - v1
    Checksum:i0637AF69C30F7B79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000033 Genomic DNA. Translation: AAV42583.1.
    RefSeqiYP_193614.1. NC_006814.3.

    Genome annotation databases

    EnsemblBacteriaiAAV42583; AAV42583; LBA0709.
    GeneIDi3251329.
    KEGGilac:LBA0709.
    PATRICi22196522. VBILacAci7974_0678.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000033 Genomic DNA. Translation: AAV42583.1 .
    RefSeqi YP_193614.1. NC_006814.3.

    3D structure databases

    ProteinModelPortali Q5FL41.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 272621.LBA0709.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV42583 ; AAV42583 ; LBA0709 .
    GeneIDi 3251329.
    KEGGi lac:LBA0709.
    PATRICi 22196522. VBILacAci7974_0678.

    Phylogenomic databases

    eggNOGi COG3842.
    KOi K11072.
    OMAi YDEPVND.
    OrthoDBi EOG6T7N3V.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR017879. ABC_Sperm/Put_ATP-bd_PotA.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR008995. Mo/tungstate-bd_C_term_dom.
    IPR027417. P-loop_NTPase.
    IPR005893. Sp_pt_ABC_ATP-bd.
    IPR013611. Transp-assoc_OB_typ2.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    PF08402. TOBE_2. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50331. SSF50331. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01187. potA. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51305. POTA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700396 / NCK56 / N2 / NCFM.

    Entry informationi

    Entry nameiPOTA_LACAC
    AccessioniPrimary (citable) accession number: Q5FL41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: March 1, 2005
    Last modified: July 9, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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