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Q5FL41 (POTA_LACAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Spermidine/putrescine import ATP-binding protein PotA

EC=3.6.3.31
Gene names
Name:potA
Ordered Locus Names:LBA0709
OrganismLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) [Complete proteome] [HAMAP]
Taxonomic identifier272621 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system By similarity.

Catalytic activity

ATP + H2O + polyamine(Out) = ADP + phosphate + polyamine(In).

Subunit structure

The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD) Potential.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. [View classification]

Contains 1 ABC transporter domain.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentATP-binding cassette (ABC) transporter complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

putrescine-importing ATPase activity

Inferred from electronic annotation. Source: InterPro

spermidine-importing ATPase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Spermidine/putrescine import ATP-binding protein PotA
PRO_0000286226

Regions

Domain4 – 235232ABC transporter
Nucleotide binding37 – 448ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q5FL41 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 0637AF69C30F7B79

FASTA36541,156
        10         20         30         40         50         60 
MDIIKLKHIT KRYDDGFIAL KDINITIESG KFYSLLGPSG SGKSTILRII AGFTQPSSGQ 

        70         80         90        100        110        120 
VFFDGKDITD LDASKRHINT VFQNYALFPH LNVFENVAFG LKIKKKPLNE IRPAVKDALH 

       130        140        150        160        170        180 
MVRLDGYANR EISELSGGQQ QRVAIARAIV NEPKVLLLDE SLSALDKRLR KDMQFELRAI 

       190        200        210        220        230        240 
QKKLGITFIF VTHDQEEALS MSDEIFVLND GQIQQSGSPV AIYDEPVNDF VARFIGDSNI 

       250        260        270        280        290        300 
LPGRMIKDYV VEFANNKFRC ADGGIKSNEK VEVVIRPEDL DIVAPEKGKI VVTAQTQLFL 

       310        320        330        340        350        360 
GDHFEIKAID ANENEWLIHS TNGVKLGQRI GLFFDPEDIH VMRLNESQKD FDARIEKYEG 


DENED 

« Hide

References

[1]"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM."
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000033 Genomic DNA. Translation: AAV42583.1.
RefSeqYP_193614.1. NC_006814.3.

3D structure databases

ProteinModelPortalQ5FL41.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272621.LBA0709.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV42583; AAV42583; LBA0709.
GeneID3251329.
KEGGlac:LBA0709.
PATRIC22196522. VBILacAci7974_0678.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3842.
KOK11072.
OMAYDEPVND.
OrthoDBEOG6T7N3V.
ProtClustDBCLSK925162.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR017879. ABC_Sperm/Put_ATP-bd_PotA.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR008995. Mo/tungstate-bd_C_term_dom.
IPR027417. P-loop_NTPase.
IPR005893. Sp_pt_ABC_ATP-bd.
IPR013611. Transp-assoc_OB_typ2.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
PF08402. TOBE_2. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF50331. SSF50331. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01187. potA. 1 hit.
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51305. POTA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePOTA_LACAC
AccessionPrimary (citable) accession number: Q5FL41
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2005
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families