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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei287Proton donorUniRule annotation1
Active sitei308UniRule annotation1
Active sitei422UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:LBA0752
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000006381 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806561 – 445Glucose-6-phosphate isomeraseAdd BLAST445

Interactioni

Protein-protein interaction databases

STRINGi272621.LBA0752.

Structurei

3D structure databases

ProteinModelPortaliQ5FL04.
SMRiQ5FL04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000100403.
KOiK01810.
OMAiNNIGEDY.

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FL04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLIKFDSSK LTPFIHENEL SEMQAMVNAA NEELRDGTGA GSDFRGWLNL
60 70 80 90 100
PVDYDKEEFD RIKKAAKKIQ SDSDVLICIG IGGSYLGAQA AIEFLNSNFY
110 120 130 140 150
GKEDNGMPTV VFCGNSLSGS YLYDLIEWVG DKDFSINVIS KSGTTTEPSV
160 170 180 190 200
AFRIFKDKLI KKYGKEEAAK RIYATTDRQK GALKTEADAE GYEEFVVPDD
210 220 230 240 250
IGGRYSVLTA VGLLPIAASG ADIDELMKGA ADARADYTDT DLSKATPYQY
260 270 280 290 300
AAIRNILYRK GYTTEIVENY EPSLRMFGEW CKQLMGESEG KDQKGIWPSS
310 320 330 340 350
ANFTTDLHSL GQYIQEGLRN LFETVIRVEN PRHDVKIPGD EKNLDQLNFL
360 370 380 390 400
EGKSLNYVND RAYEGVVLAH TDGGVPVMTI NIPDQTAHTL GYMIYFFELA
410 420 430 440
IAISGYLNGI NPFNQPGVEA YKRNMFGLLN KPGYENLHDD LAKRL
Length:445
Mass (Da):49,507
Last modified:March 1, 2005 - v1
Checksum:i046A2A0567338400
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV42620.1.
RefSeqiWP_003546706.1. NC_006814.3.
YP_193651.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV42620; AAV42620; LBA0752.
GeneIDi3252080.
KEGGilac:LBA0752.
PATRICifig|272621.13.peg.717.

Similar proteinsi

Entry informationi

Entry nameiG6PI_LACAC
AccessioniPrimary (citable) accession number: Q5FL04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: March 1, 2005
Last modified: August 30, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families