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Q5FKK7 (LDH2_LACAC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase 2

Short name=L-LDH 2
EC=1.1.1.27
Gene names
Name:ldh2
Ordered Locus Names:LBA0910
OrganismLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) [Complete proteome] [HAMAP]
Taxonomic identifier272621 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + NAD+ = pyruvate + NADH. HAMAP MF_00488

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. HAMAP MF_00488

Subunit structure

Homotetramer By similarity. HAMAP MF_00488

Subcellular location

Cytoplasm By similarity HAMAP MF_00488.

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-lactate dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308L-lactate dehydrogenase 2 HAMAP MF_00488
PRO_0000237548

Regions

Nucleotide binding11 – 3929NAD By similarity

Sites

Active site1741Proton acceptor
Binding site871Substrate By similarity
Binding site1191NAD or substrate By similarity
Binding site1501Substrate By similarity
Binding site2241Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5FKK7 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: A9BC556A14F44E83

FASTA30833,349
        10         20         30         40         50         60 
MSRKVFLVGD GAVGSTFAND LLQNTTVDEL AIFDVAKDRP VGDSMDLEDI TPFTGQTNIH 

        70         80         90        100        110        120 
PAEYSDAKDA DVCVITAGVP RKPGETRLDL VNKNVKILKT IVDPVVESGF KGVFVVSANP 

       130        140        150        160        170        180 
VDILTTLTQK ISGFPKDRVI GTGTSLDSMR LRVELAKKLN VPVAKVNSMV LGEHGDTSFE 

       190        200        210        220        230        240 
NFDESTVDNK PLRDYSEIND NVLSEIESDV RKKGGKIITN KGATFYGVAM MLTQIVSAIL 

       250        260        270        280        290        300 
DNRSICLPLS APINGEYGIK HDLYLGTPTI INGNGIEKVI ETKLSDVEKA KMINSADKMQ 


EVLSGVEM 

« Hide

References

[1]"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM."
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005) [PubMed: 15671160] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000033 Genomic DNA. Translation: AAV42767.1.
RefSeqYP_193798.1. NC_006814.3.

3D structure databases

ProteinModelPortalQ5FKK7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3251850.
GenomeReviewsGene locus LBA0910 in contig CP000033_GR.
KEGGlac:LBA0910.
NMPDRfig|272621.3.peg.903.
PATRIC22196908. VBILacAci7974_0868.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG566126.
OMADYSEIND.
ProtClustDBPRK00066.

Enzyme and pathway databases

BioCycLACI272621:LBA0910-MONOMER.

Family and domain databases

HAMAPMF_00488. Lactate_dehydrog.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00016.
PANTHERPTHR11540:SF3. PTHR11540:SF3. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01771. L-LDH-NAD. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLDH2_LACAC
AccessionPrimary (citable) accession number: Q5FKK7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2005
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families