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Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54IronUniRule annotation1
Metal bindingi58IronUniRule annotation1
Metal bindingi124IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAutoinducer synthesis, Quorum sensing
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciLACI272621:G1G49-1077-MONOMER
BRENDAi4.4.1.21 2846

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
Alternative name(s):
AI-2 synthesis proteinUniRule annotation
Autoinducer-2 production protein LuxSUniRule annotation
Gene namesi
Name:luxSUniRule annotation
Ordered Locus Names:LBA1081
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002980031 – 157S-ribosylhomocysteine lyaseAdd BLAST157

Proteomic databases

PRIDEiQ5FK48

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272621.LBA1081

Structurei

3D structure databases

ProteinModelPortaliQ5FK48
SMRiQ5FK48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106762 Bacteria
COG1854 LUCA
HOGENOMiHOG000040372
KOiK07173
OMAiQWSRDIL

Family and domain databases

Gene3Di3.30.1360.80, 1 hit
HAMAPiMF_00091 LuxS, 1 hit
InterProiView protein in InterPro
IPR037005 LuxS_sf
IPR011249 Metalloenz_LuxS/M16
IPR003815 S-ribosylhomocysteinase
PANTHERiPTHR35799 PTHR35799, 1 hit
PfamiView protein in Pfam
PF02664 LuxS, 1 hit
PIRSFiPIRSF006160 AI2, 1 hit
PRINTSiPR01487 LUXSPROTEIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013172 S-ribosylhomocysteinase, 1 hit
SUPFAMiSSF63411 SSF63411, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FK48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVESFTLD HTKVKAPYVR LITVEEGPKG DKISNYDLRL VQPNENAIPT
60 70 80 90 100
GGLHTIEHLL ASLLRDRLDG VIDCSPFGCR TGFHLIVWGE HSTTEVAKAL
110 120 130 140 150
KSSLEEIRDT ITWEDVPGTT IKTCGNYRDH SLFTAKEWCR DILEKGISDD

PFERNVI
Length:157
Mass (Da):17,665
Last modified:March 1, 2005 - v1
Checksum:iF8FA3D40975AED64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA Translation: AAV42926.1
RefSeqiWP_003547404.1, NC_006814.3
YP_193957.1, NC_006814.3

Genome annotation databases

EnsemblBacteriaiAAV42926; AAV42926; LBA1081
GeneIDi3253048
KEGGilac:LBA1081
PATRICifig|272621.13.peg.1030

Entry informationi

Entry nameiLUXS_LACAC
AccessioniPrimary (citable) accession number: Q5FK48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2005
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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