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Q5FK38 (CAPP_LACAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxylase

Short name=PEPC
Short name=PEPCase
EC=4.1.1.31
Gene names
Name:ppc
Ordered Locus Names:LBA1092
OrganismLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) [Complete proteome] [HAMAP]
Taxonomic identifier272621 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length912 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595

Catalytic activity

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_00595

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00595

Sequence similarities

Belongs to the PEPCase type 1 family.

Ontologies

Keywords
   Biological processCarbon dioxide fixation
   LigandMagnesium
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbon fixation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

oxaloacetate metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphoenolpyruvate carboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 912912Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595
PRO_0000166598

Sites

Active site1381 By similarity
Active site5751 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5FK38 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: EE482B5472CFC8D4

FASTA912104,353
        10         20         30         40         50         60 
MTFTKLENSS DQAVVAEEVK ILTKLLNEST RQLIGDDAFA KIQDLIDTSA SKDQKQLESK 

        70         80         90        100        110        120 
ISSLNNREMI VVARYFATLP LLINISEDVE LASKVNVFNN TDQDYLGKLS DTIDLVAQKD 

       130        140        150        160        170        180 
DAKRILENVN VVPVLTAHPT QIQRKTVLEL TDKIHHLLRS YRDVKNGTIN QREWTEQLRA 

       190        200        210        220        230        240 
CIEILMQTDI IRGHKLKVSN EITNVLAYYP KALIPAITKF TTRYKELAKE HNLTLDQATP 

       250        260        270        280        290        300 
ITMGMWIGGD RDGNPYVTAD TLELSATLQS QVIFEYYMKE LKKLYRAISL STSYMQPSAA 

       310        320        330        340        350        360 
VEKLSKLSND DSPFRTDEPY RRAFYYIESR LVHTEKELLG IIDKNIFIKP HDLENLDNIP 

       370        380        390        400        410        420 
VYNNPQEFKS DLETIKASLD EDHDQAVTHS FFTQILEAID VFGFHLATID MRQDSSVNES 

       430        440        450        460        470        480 
CVAELLKSAG ICDNYSDLSE KEKVELLLSE LENDPRNLHA NNKPKSELLQ KELKIYKTAR 

       490        500        510        520        530        540 
QLKDRLGEDV IKQHIISHTE SVSDMLEQAI MLKEYNLVDS EKARIQVVPL FETVEDLLNA 

       550        560        570        580        590        600 
REIITQYLSF PIVKKWLVSQ NNYQEIMLGY SDSNKDGGYL ASCWNLYKAQ KDLTAIGEKL 

       610        620        630        640        650        660 
GVKITYMHGR GGTVGRGGGP SYEAITAQPF KSINDRIRMT EQGEIIQNKY GNKDTAYYNL 

       670        680        690        700        710        720 
EMLASAAIDR MVSKQAVSEE RITDFRSSMD KIVEESNKIY RKLVFENPAF LDYFFQATPI 

       730        740        750        760        770        780 
KEISNLNIGS RPASRKKLTD FSGLRAIPWV FSWSQSRIMF PGWYGVGSAF ANFINADPTH 

       790        800        810        820        830        840 
LKELQEMYKG WPFFHSLLSN VDMFLSKSNM EIAREYASLC DDEETKKVFD IIYQEWKLTK 

       850        860        870        880        890        900 
KVILQIEDHD DLLAEAPILK QSLDYRMPYF NILNYIQIEM IKRGREDEIQ GVYQSIIPIT 

       910 
INGVASGLRN SG 

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References

[1]"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM."
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000033 Genomic DNA. Translation: AAV42936.1.
RefSeqYP_193967.1. NC_006814.3.

3D structure databases

ProteinModelPortalQ5FK38.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272621.LBA1092.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV42936; AAV42936; LBA1092.
GeneID3253079.
KEGGlac:LBA1092.
PATRIC22197250. VBILacAci7974_1039.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2352.
HOGENOMHOG000238647.
KOK01595.
OMAELSTISC.
OrthoDBEOG6TJ7T8.

Family and domain databases

HAMAPMF_00595. PEPcase_type1.
InterProIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSPR00150. PEPCARBXLASE.
SUPFAMSSF51621. SSF51621. 1 hit.
PROSITEPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCAPP_LACAC
AccessionPrimary (citable) accession number: Q5FK38
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families