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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei575 – 5751UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:LBA1092
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006381 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 912912Phosphoenolpyruvate carboxylasePRO_0000166598Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272621.LBA1092.

Structurei

3D structure databases

ProteinModelPortaliQ5FK38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FK38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFTKLENSS DQAVVAEEVK ILTKLLNEST RQLIGDDAFA KIQDLIDTSA
60 70 80 90 100
SKDQKQLESK ISSLNNREMI VVARYFATLP LLINISEDVE LASKVNVFNN
110 120 130 140 150
TDQDYLGKLS DTIDLVAQKD DAKRILENVN VVPVLTAHPT QIQRKTVLEL
160 170 180 190 200
TDKIHHLLRS YRDVKNGTIN QREWTEQLRA CIEILMQTDI IRGHKLKVSN
210 220 230 240 250
EITNVLAYYP KALIPAITKF TTRYKELAKE HNLTLDQATP ITMGMWIGGD
260 270 280 290 300
RDGNPYVTAD TLELSATLQS QVIFEYYMKE LKKLYRAISL STSYMQPSAA
310 320 330 340 350
VEKLSKLSND DSPFRTDEPY RRAFYYIESR LVHTEKELLG IIDKNIFIKP
360 370 380 390 400
HDLENLDNIP VYNNPQEFKS DLETIKASLD EDHDQAVTHS FFTQILEAID
410 420 430 440 450
VFGFHLATID MRQDSSVNES CVAELLKSAG ICDNYSDLSE KEKVELLLSE
460 470 480 490 500
LENDPRNLHA NNKPKSELLQ KELKIYKTAR QLKDRLGEDV IKQHIISHTE
510 520 530 540 550
SVSDMLEQAI MLKEYNLVDS EKARIQVVPL FETVEDLLNA REIITQYLSF
560 570 580 590 600
PIVKKWLVSQ NNYQEIMLGY SDSNKDGGYL ASCWNLYKAQ KDLTAIGEKL
610 620 630 640 650
GVKITYMHGR GGTVGRGGGP SYEAITAQPF KSINDRIRMT EQGEIIQNKY
660 670 680 690 700
GNKDTAYYNL EMLASAAIDR MVSKQAVSEE RITDFRSSMD KIVEESNKIY
710 720 730 740 750
RKLVFENPAF LDYFFQATPI KEISNLNIGS RPASRKKLTD FSGLRAIPWV
760 770 780 790 800
FSWSQSRIMF PGWYGVGSAF ANFINADPTH LKELQEMYKG WPFFHSLLSN
810 820 830 840 850
VDMFLSKSNM EIAREYASLC DDEETKKVFD IIYQEWKLTK KVILQIEDHD
860 870 880 890 900
DLLAEAPILK QSLDYRMPYF NILNYIQIEM IKRGREDEIQ GVYQSIIPIT
910
INGVASGLRN SG
Length:912
Mass (Da):104,353
Last modified:March 1, 2005 - v1
Checksum:iEE482B5472CFC8D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV42936.1.
RefSeqiWP_011254335.1. NC_006814.3.
YP_193967.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV42936; AAV42936; LBA1092.
GeneIDi3253079.
KEGGilac:LBA1092.
PATRICi22197250. VBILacAci7974_1039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV42936.1.
RefSeqiWP_011254335.1. NC_006814.3.
YP_193967.1. NC_006814.3.

3D structure databases

ProteinModelPortaliQ5FK38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272621.LBA1092.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV42936; AAV42936; LBA1092.
GeneIDi3253079.
KEGGilac:LBA1092.
PATRICi22197250. VBILacAci7974_1039.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Entry informationi

Entry nameiCAPP_LACAC
AccessioniPrimary (citable) accession number: Q5FK38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2005
Last modified: May 27, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.