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Q5FJY2

- FTHS1_LACAC

UniProt

Q5FJY2 - FTHS1_LACAC

Protein

Formate--tetrahydrofolate ligase 1

Gene

fhs1

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 738ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligase 1UniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetase 1UniRule annotation
    Short name:
    FHS 1UniRule annotation
    Short name:
    FTHFS 1UniRule annotation
    Gene namesi
    Name:fhs1UniRule annotation
    Ordered Locus Names:LBA1153
    OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
    Taxonomic identifieri272621 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000006381: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Formate--tetrahydrofolate ligase 1PRO_0000199351Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272621.LBA1153.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FJY2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiARFIVVT.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FJY2-1 [UniParc]FASTAAdd to Basket

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    MKSDIEIAQE TKELPIEEIA AKVNLKKEDL EPYGQDKAKI NWKAINRIRK    50
    NDKLGKLILV TSISPTPAGE GKSTITIGLG DAIHNQLHKN TLIALREPSM 100
    GPVFGLKGGA TGGGRAQIIP MEDINLHFTG DMHALTAAID TLAALVDNYI 150
    YQDNSLNIDP ERILLKRGLD VNDRALRKIT VGQGSKFNGI EHKASFAITV 200
    ANELMAILCL ANDINDLKAR IGDMLVGYTQ DDQPVYVKQL GFQGAIAALL 250
    SNALKPNLVQ TLEHTPALVH GGPFANIAHG ANSVMATNLA LHLSDYVLTE 300
    AGFGSDLGGQ KFMDFVSKHL DKTPDAAVVV ATVRALKYQA LGSTDKLDEE 350
    NLDALKTGFK NLERHMNNMR SYNVPVIVLI NRFDTDTDKE LELLKELVEK 400
    QGIKAEVVTY HNEGSKGGSR AAQEVINLAD SGKAELISTY NEDDDIKSKI 450
    KKIATKIYHA DGVEYTDKAE EQIKELAKIG KDKLPVIIAK TQYSFSDDKK 500
    KLGAPGGFNL HVKGVSLKNG ARFIVVTTGN VLDMPGLPKH PAALDIDVDN 550
    DGKISGLF 558
    Length:558
    Mass (Da):60,595
    Last modified:March 1, 2005 - v1
    Checksum:iE5F4B694A0176CA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000033 Genomic DNA. Translation: AAV42992.1.
    RefSeqiYP_194023.1. NC_006814.3.

    Genome annotation databases

    EnsemblBacteriaiAAV42992; AAV42992; LBA1153.
    GeneIDi3252922.
    KEGGilac:LBA1153.
    PATRICi22197360. VBILacAci7974_1094.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000033 Genomic DNA. Translation: AAV42992.1 .
    RefSeqi YP_194023.1. NC_006814.3.

    3D structure databases

    ProteinModelPortali Q5FJY2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272621.LBA1153.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV42992 ; AAV42992 ; LBA1153 .
    GeneIDi 3252922.
    KEGGi lac:LBA1153.
    PATRICi 22197360. VBILacAci7974_1094.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi ARFIVVT.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700396 / NCK56 / N2 / NCFM.

    Entry informationi

    Entry nameiFTHS1_LACAC
    AccessioniPrimary (citable) accession number: Q5FJY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3