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Protein

Formate--tetrahydrofolate ligase 1

Gene

fhs1

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 1UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 1UniRule annotation
Short name:
FHS 1UniRule annotation
Short name:
FTHFS 1UniRule annotation
Gene namesi
Name:fhs1UniRule annotation
Ordered Locus Names:LBA1153
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006381 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligase 1PRO_0000199351Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272621.LBA1153.

Structurei

3D structure databases

ProteinModelPortaliQ5FJY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiDNYIYQD.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FJY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDIEIAQE TKELPIEEIA AKVNLKKEDL EPYGQDKAKI NWKAINRIRK
60 70 80 90 100
NDKLGKLILV TSISPTPAGE GKSTITIGLG DAIHNQLHKN TLIALREPSM
110 120 130 140 150
GPVFGLKGGA TGGGRAQIIP MEDINLHFTG DMHALTAAID TLAALVDNYI
160 170 180 190 200
YQDNSLNIDP ERILLKRGLD VNDRALRKIT VGQGSKFNGI EHKASFAITV
210 220 230 240 250
ANELMAILCL ANDINDLKAR IGDMLVGYTQ DDQPVYVKQL GFQGAIAALL
260 270 280 290 300
SNALKPNLVQ TLEHTPALVH GGPFANIAHG ANSVMATNLA LHLSDYVLTE
310 320 330 340 350
AGFGSDLGGQ KFMDFVSKHL DKTPDAAVVV ATVRALKYQA LGSTDKLDEE
360 370 380 390 400
NLDALKTGFK NLERHMNNMR SYNVPVIVLI NRFDTDTDKE LELLKELVEK
410 420 430 440 450
QGIKAEVVTY HNEGSKGGSR AAQEVINLAD SGKAELISTY NEDDDIKSKI
460 470 480 490 500
KKIATKIYHA DGVEYTDKAE EQIKELAKIG KDKLPVIIAK TQYSFSDDKK
510 520 530 540 550
KLGAPGGFNL HVKGVSLKNG ARFIVVTTGN VLDMPGLPKH PAALDIDVDN

DGKISGLF
Length:558
Mass (Da):60,595
Last modified:March 1, 2005 - v1
Checksum:iE5F4B694A0176CA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV42992.1.
RefSeqiWP_011254358.1. NC_006814.3.
YP_194023.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV42992; AAV42992; LBA1153.
GeneIDi3252922.
KEGGilac:LBA1153.
PATRICi22197360. VBILacAci7974_1094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV42992.1.
RefSeqiWP_011254358.1. NC_006814.3.
YP_194023.1. NC_006814.3.

3D structure databases

ProteinModelPortaliQ5FJY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272621.LBA1153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV42992; AAV42992; LBA1153.
GeneIDi3252922.
KEGGilac:LBA1153.
PATRICi22197360. VBILacAci7974_1094.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiDNYIYQD.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Entry informationi

Entry nameiFTHS1_LACAC
AccessioniPrimary (citable) accession number: Q5FJY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2005
Last modified: May 27, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.