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Protein

ATP-dependent helicase/deoxyribonuclease subunit B

Gene

rexB

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLACI272621:G1G49-1156-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase/deoxyribonuclease subunit BUniRule annotation (EC:3.1.-.-UniRule annotation, EC:3.6.4.12UniRule annotation)
Alternative name(s):
ATP-dependent helicase/nuclease RexBUniRule annotation
Gene namesi
Name:rexBUniRule annotation
Ordered Locus Names:LBA1166
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000006381 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003793651 – 1160ATP-dependent helicase/deoxyribonuclease subunit BAdd BLAST1160

Interactioni

Subunit structurei

Heterodimer of AddA and RexB.UniRule annotation

Protein-protein interaction databases

STRINGi272621.LBA1166

Structurei

3D structure databases

ProteinModelPortaliQ5FJW9
SMRiQ5FJW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the helicase family. AddB/RexB type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C5N Bacteria
COG3857 LUCA
HOGENOMiHOG000033807
KOiK16899
OMAiHFASHGL

Family and domain databases

HAMAPiMF_01453 AddB_type2, 1 hit
InterProiView protein in InterPro
IPR014141 DNA_helicase_suRexB
IPR027417 P-loop_NTPase
IPR038726 PDDEXK_AddAB-type
PfamiView protein in Pfam
PF12705 PDDEXK_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FJW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKILTGRQT DPVQEKILEE AVKNYQQHPE NETFIIVPNH IKFTTEVRAI
60 70 80 90 100
NKLATSKNKS ETAVKNLHVL SFSRLAWFFL KDAEQGLPTQ LDDAASAMLL
110 120 130 140 150
THIIEKEKDN LTIFETINSG LVQQLYNTIL QMYDGNIDLD NIDETNLDQE
160 170 180 190 200
TKSKIHDLRI IYDAYIKEIA GKFSTKNEVQ VELNKVLANN KSLSNASFYF
210 220 230 240 250
CDFSHFSLQE TLTIKLLIRK AQNVILGFKT KLGDINPQAE AGDYDYVIQQ
260 270 280 290 300
TIKRFTSFLQ ERNINYTVNN FPLSSKPTNR ENLNSLWTES INKVDNIKKH
310 320 330 340 350
VQLVKADSRY AEAYFVARSI YQQVALGNYR YHDFLILAPD LKEYETYLTP
360 370 380 390 400
ILRQNKIPFF NDLQQEMKYH PLVVLIESLF NMYDEKTISL NTQSIIAILK
410 420 430 440 450
THLMIPSWYK EEAEFIHDVD ELENFVLAHG IEHNLWQRPF SHFVNAEVIR
460 470 480 490 500
LDKMDEEIAK LNRLREFLIN KITELLEKLK KEESSQKALT MFFDFLTNNG
510 520 530 540 550
IASRLEQWRN DANDAGDLQQ AQQPEQLWDL LIQLLKDYLM INPEKFDVDE
560 570 580 590 600
FFNMLINAFR EANFSQIPST LDAVNLSELG MVQTGGYKQV FIIGATSGNL
610 620 630 640 650
PAIQKTPGFL TPENINQLQN SFASDAYLED NQQLNNLDQN YQFGLALALA
660 670 680 690 700
QDKVYVSYPI LNASNERLDS SIYYKRLFDY VDSEFEQHDL PEKFNDLLSF
710 720 730 740 750
ITSADASLGY LSYINSIDSS KEFDELLRIT HEQSPQKTEI VLQASEFNNQ
760 770 780 790 800
PEDIGQELAE KLYGQNLNSS VSQLETFYEN SYEYFLTYGL RLHRRLENEF
810 820 830 840 850
DVIQAGNYFH ETFDRLVKQL NKEHIDLASL NSFELERMLN SVRNVMKNEG
860 870 880 890 900
KYAQLMNDPF NEYLFKCLDH TTSKVAHNWC KNLNKTPLRA KYSELSFGVG
910 920 930 940 950
EKLKGLSLDV PNLSGNHRVD LRGKMDRVDI AHLADKNQVL AQVIDYKSSA
960 970 980 990 1000
KKFDLSMFYN GIAMQMVSYL DILVKNNQFF AGNNELSLLG AFYQTVTRQL
1010 1020 1030 1040 1050
ERLNSNKLID SQLNIRDNVI DGKPKLMYTG LINNNPQVLT EAEPFLDNSS
1060 1070 1080 1090 1100
RQSELYSMVK TKKNGTFSLP TDRSFSEEEL ELLLEYDEFL IKEASNQILS
1110 1120 1130 1140 1150
GKIELNPYRQ GKSKSALTYS DYKDIFFFDA MLRQNQYHEI TRLSKKDLLS
1160
KIKERLGKED
Length:1,160
Mass (Da):134,304
Last modified:March 1, 2005 - v1
Checksum:i7D7C51AA3878B1C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA Translation: AAV43005.1
RefSeqiWP_011254367.1, NC_006814.3
YP_194036.1, NC_006814.3

Genome annotation databases

EnsemblBacteriaiAAV43005; AAV43005; LBA1166
GeneIDi3253068
KEGGilac:LBA1166
PATRICifig|272621.13.peg.1108

Similar proteinsi

Entry informationi

Entry nameiADDB_LACAC
AccessioniPrimary (citable) accession number: Q5FJW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: March 1, 2005
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health