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Protein

ATP-dependent helicase/deoxyribonuclease subunit B

Gene

rexB

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase/deoxyribonuclease subunit BUniRule annotation (EC:3.1.-.-UniRule annotation, EC:3.6.4.12UniRule annotation)
Alternative name(s):
ATP-dependent helicase/nuclease RexBUniRule annotation
Gene namesi
Name:rexBUniRule annotation
Ordered Locus Names:LBA1166
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000006381 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003793651 – 1160ATP-dependent helicase/deoxyribonuclease subunit BAdd BLAST1160

Interactioni

Subunit structurei

Heterodimer of AddA and RexB.UniRule annotation

Protein-protein interaction databases

STRINGi272621.LBA1166.

Structurei

3D structure databases

ProteinModelPortaliQ5FJW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the helicase family. AddB/RexB type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C5N. Bacteria.
COG3857. LUCA.
HOGENOMiHOG000033807.
KOiK16899.
OMAiDYKSSAK.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01453. AddB_type2. 1 hit.
InterProiIPR014141. DNA_helicase_suRexB.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FJW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKILTGRQT DPVQEKILEE AVKNYQQHPE NETFIIVPNH IKFTTEVRAI
60 70 80 90 100
NKLATSKNKS ETAVKNLHVL SFSRLAWFFL KDAEQGLPTQ LDDAASAMLL
110 120 130 140 150
THIIEKEKDN LTIFETINSG LVQQLYNTIL QMYDGNIDLD NIDETNLDQE
160 170 180 190 200
TKSKIHDLRI IYDAYIKEIA GKFSTKNEVQ VELNKVLANN KSLSNASFYF
210 220 230 240 250
CDFSHFSLQE TLTIKLLIRK AQNVILGFKT KLGDINPQAE AGDYDYVIQQ
260 270 280 290 300
TIKRFTSFLQ ERNINYTVNN FPLSSKPTNR ENLNSLWTES INKVDNIKKH
310 320 330 340 350
VQLVKADSRY AEAYFVARSI YQQVALGNYR YHDFLILAPD LKEYETYLTP
360 370 380 390 400
ILRQNKIPFF NDLQQEMKYH PLVVLIESLF NMYDEKTISL NTQSIIAILK
410 420 430 440 450
THLMIPSWYK EEAEFIHDVD ELENFVLAHG IEHNLWQRPF SHFVNAEVIR
460 470 480 490 500
LDKMDEEIAK LNRLREFLIN KITELLEKLK KEESSQKALT MFFDFLTNNG
510 520 530 540 550
IASRLEQWRN DANDAGDLQQ AQQPEQLWDL LIQLLKDYLM INPEKFDVDE
560 570 580 590 600
FFNMLINAFR EANFSQIPST LDAVNLSELG MVQTGGYKQV FIIGATSGNL
610 620 630 640 650
PAIQKTPGFL TPENINQLQN SFASDAYLED NQQLNNLDQN YQFGLALALA
660 670 680 690 700
QDKVYVSYPI LNASNERLDS SIYYKRLFDY VDSEFEQHDL PEKFNDLLSF
710 720 730 740 750
ITSADASLGY LSYINSIDSS KEFDELLRIT HEQSPQKTEI VLQASEFNNQ
760 770 780 790 800
PEDIGQELAE KLYGQNLNSS VSQLETFYEN SYEYFLTYGL RLHRRLENEF
810 820 830 840 850
DVIQAGNYFH ETFDRLVKQL NKEHIDLASL NSFELERMLN SVRNVMKNEG
860 870 880 890 900
KYAQLMNDPF NEYLFKCLDH TTSKVAHNWC KNLNKTPLRA KYSELSFGVG
910 920 930 940 950
EKLKGLSLDV PNLSGNHRVD LRGKMDRVDI AHLADKNQVL AQVIDYKSSA
960 970 980 990 1000
KKFDLSMFYN GIAMQMVSYL DILVKNNQFF AGNNELSLLG AFYQTVTRQL
1010 1020 1030 1040 1050
ERLNSNKLID SQLNIRDNVI DGKPKLMYTG LINNNPQVLT EAEPFLDNSS
1060 1070 1080 1090 1100
RQSELYSMVK TKKNGTFSLP TDRSFSEEEL ELLLEYDEFL IKEASNQILS
1110 1120 1130 1140 1150
GKIELNPYRQ GKSKSALTYS DYKDIFFFDA MLRQNQYHEI TRLSKKDLLS
1160
KIKERLGKED
Length:1,160
Mass (Da):134,304
Last modified:March 1, 2005 - v1
Checksum:i7D7C51AA3878B1C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV43005.1.
RefSeqiWP_011254367.1. NC_006814.3.
YP_194036.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV43005; AAV43005; LBA1166.
GeneIDi3253068.
KEGGilac:LBA1166.
PATRICi22197388. VBILacAci7974_1108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000033 Genomic DNA. Translation: AAV43005.1.
RefSeqiWP_011254367.1. NC_006814.3.
YP_194036.1. NC_006814.3.

3D structure databases

ProteinModelPortaliQ5FJW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272621.LBA1166.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV43005; AAV43005; LBA1166.
GeneIDi3253068.
KEGGilac:LBA1166.
PATRICi22197388. VBILacAci7974_1108.

Phylogenomic databases

eggNOGiENOG4105C5N. Bacteria.
COG3857. LUCA.
HOGENOMiHOG000033807.
KOiK16899.
OMAiDYKSSAK.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01453. AddB_type2. 1 hit.
InterProiIPR014141. DNA_helicase_suRexB.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADDB_LACAC
AccessioniPrimary (citable) accession number: Q5FJW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.