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Q5FJD5 (Q5FJD5_LACAC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Beta-galactosidase PIRNR PIRNR001084
Short name=Beta-gal PIRNR PIRNR001084
EC=3.2.1.23 PIRNR PIRNR001084
Gene names
Name:lacA EMBL AAV43189.1
Ordered Locus Names:LBA1364
OrganismLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) [Complete proteome] [HAMAP]
Taxonomic identifier272621 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length680 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. PIRNR PIRNR001084

Sequence similarities

Belongs to the glycosyl hydrolase 42 family. PIRNR PIRNR001084

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1531Proton donor By similarity PIRSR PIRSR001084-1
Active site3161Nucleophile By similarity PIRSR PIRSR001084-1
Metal binding1181Zinc By similarity PIRSR PIRSR001084-3
Metal binding1581Zinc By similarity PIRSR PIRSR001084-3
Metal binding1601Zinc By similarity PIRSR PIRSR001084-3
Metal binding1631Zinc By similarity PIRSR PIRSR001084-3
Binding site1141Substrate By similarity PIRSR PIRSR001084-2
Binding site1521Substrate By similarity PIRSR PIRSR001084-2
Binding site3241Substrate By similarity PIRSR PIRSR001084-2

Sequences

Sequence LengthMass (Da)Tools
Q5FJD5 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 1D17E878BF3E51CE

FASTA68079,348
        10         20         30         40         50         60 
MKRELKSKVF LHGGDYNPEQ WLGEPEIINE DFALFKNAAI NTVTVGIFSW AKLEPEEGKY 

        70         80         90        100        110        120 
DFAWLDDIFD RVEKMNGYVI LATPSGARPA WLARKYPEVL RTDFNNQKRG FGGRHNHCLT 

       130        140        150        160        170        180 
SPIYRKKVRE INTKLAEHFG KRPSLILWHI SNEYSGECYC DLCQQAFRDW LKKKYRTLER 

       190        200        210        220        230        240 
LNHSWWNTFW SHTFSDWNQI HAPSPLSEMG NKGMNLDWKR FVSDQAISFI DNEVEPLRKI 

       250        260        270        280        290        300 
TSEIPVTTNM MAGNPLMDPF TGYNYQEMAK HLDVISWDSY PLWGNDFQST EKLGQNVGLI 

       310        320        330        340        350        360 
HDFFRSLKHQ NFMIMENTPS RVNWADIDRA KRPGMHQLAS LQDIAHSSDS VLYFQLRASR 

       370        380        390        400        410        420 
GSAEMFHGAV IEHRHPEKTR VFHDVKDVGH DLEKLESIYS TSYTKAKVGI VYDYNNIWAL 

       430        440        450        460        470        480 
EDAEGYSKDK KIWQTIQSQY QYFYQNDIPV DFVSPNDNFT QYKLLIDPMH FLMTKEYMDK 

       490        500        510        520        530        540 
LESFVKKCGY VVGTYISGVV DENGLAYMNE WPKQLQSIYG IEPLETDSLY PKQSNSIEFA 

       550        560        570        580        590        600 
GHRYQAYDFC ETIFKHDAKV LAKYTTDFYS GTPALTAHKC GEGKGYYIAC RTDTDFLSAI 

       610        620        630        640        650        660 
YGQIVKELDL LPNLPIKKET TKISLQVREN DDEKYLFVQN FSHEQQSILL KQKMKEMLSD 

       670        680 
EFEENKVIVK PYGTKIYQMN

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References

[1]"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM."
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005) [PubMed: 15671160] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000033 Genomic DNA. Translation: AAV43189.1.
RefSeqYP_194220.1. NC_006814.3.

3D structure databases

ProteinModelPortalQ5FJD5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3252620.
GenomeReviewsGene locus LBA1364 in contig CP000033_GR.
KEGGlac:LBA1364.
NMPDRfig|272621.3.peg.1281.
PATRIC22197754. VBILacAci7974_1290.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG476453.
OMAAKRPGMH.
ProtClustDBCLSK582025.

Family and domain databases

InterProIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR013780. Glyco_hydro_13_b.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_subgr_catalytic.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
Gene3DG3DSA:2.60.40.1180. Glyco_hydro_13_b. 1 hit.
G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KOK12308.
PfamPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFPIRSF001084. B-galactosidase. 1 hit.
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ5FJD5_LACAC
AccessionPrimary (citable) accession number: Q5FJD5
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2005
Last sequence update: March 1, 2005
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info