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Q5FIU5

- FTHS2_LACAC

UniProt

Q5FIU5 - FTHS2_LACAC

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Protein
Formate--tetrahydrofolate ligase 2
Gene
fhs2, LBA1562
Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 708ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 2 (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase 2
Short name:
FHS 2
Short name:
FTHFS 2
Gene namesi
Name:fhs2
Ordered Locus Names:LBA1562
OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Taxonomic identifieri272621 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006381: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligase 2UniRule annotation
PRO_0000199352Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272621.LBA1562.

Structurei

3D structure databases

ProteinModelPortaliQ5FIU5.
SMRiQ5FIU5. Positions 4-551.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FIU5-1 [UniParc]FASTAAdd to Basket

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MPTDIEIADA AKMQPITEIA QKLGLSSDDI EQYGHYKAKI NLPVKEVEGK    50
KHKLILVTGI NPTSAGEGKS TVLVGLGDAL NQLGHQTTIA MREPSMGPVF 100
GIKGGATGGG YSQVVPMEDI NLHFTGDMHA LTSANNTLAA LIDNYIMRDN 150
VLGLDPRRII WKRVEDVNDR VLRNVVTGLG GIMQGVPRET GFDITAASEM 200
MAILCLSESL HNLKKRIGRI VVGYTYEKKP VTVDQLGFTG AITLLLKDAI 250
KPNLVQTLDH TPAIIHGGPF ANIAHGCNSV LATQIALKTS DYTVTECGFG 300
ADLGAEKFLD IKRPVLGETP NAVVIVATAR ALKLNGGADK DELTKEDIPA 350
LEKGMANLRR HVENMQKYNL PIVVAINHFN SDTEAEIKTI QDACAEMGVK 400
AIEVDAWAKG GQGTQDLAKE VVKLADEELE FHELYKNSDS IEDKLSAIAT 450
KIYGAKRVVL SKKAKRQIKT FNEQGWNDLP VCIAKTQYSF TDDQTKLGAP 500
TDFDFHIRDL VPKLGAGFIV ALSGTMMTMP GLAKHPAAEN MDIDDNGQIA 550
GLF 553
Length:553
Mass (Da):59,847
Last modified:March 1, 2005 - v1
Checksum:i09FF57B54CB4EEF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000033 Genomic DNA. Translation: AAV43379.1.
RefSeqiYP_194410.1. NC_006814.3.

Genome annotation databases

EnsemblBacteriaiAAV43379; AAV43379; LBA1562.
GeneIDi3251186.
KEGGilac:LBA1562.
PATRICi22198142. VBILacAci7974_1484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000033 Genomic DNA. Translation: AAV43379.1 .
RefSeqi YP_194410.1. NC_006814.3.

3D structure databases

ProteinModelPortali Q5FIU5.
SMRi Q5FIU5. Positions 4-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272621.LBA1562.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV43379 ; AAV43379 ; LBA1562 .
GeneIDi 3251186.
KEGGi lac:LBA1562.
PATRICi 22198142. VBILacAci7974_1484.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Entry informationi

Entry nameiFTHS2_LACAC
AccessioniPrimary (citable) accession number: Q5FIU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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