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Q5FIU5

- FTHS2_LACAC

UniProt

Q5FIU5 - FTHS2_LACAC

Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi63 – 708ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetase 2UniRule annotation
    Short name:
    FHS 2UniRule annotation
    Short name:
    FTHFS 2UniRule annotation
    Gene namesi
    Name:fhs2UniRule annotation
    Ordered Locus Names:LBA1562
    OrganismiLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
    Taxonomic identifieri272621 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000006381: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Formate--tetrahydrofolate ligase 2PRO_0000199352Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272621.LBA1562.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FIU5.
    SMRiQ5FIU5. Positions 4-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FIU5-1 [UniParc]FASTAAdd to Basket

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    MPTDIEIADA AKMQPITEIA QKLGLSSDDI EQYGHYKAKI NLPVKEVEGK    50
    KHKLILVTGI NPTSAGEGKS TVLVGLGDAL NQLGHQTTIA MREPSMGPVF 100
    GIKGGATGGG YSQVVPMEDI NLHFTGDMHA LTSANNTLAA LIDNYIMRDN 150
    VLGLDPRRII WKRVEDVNDR VLRNVVTGLG GIMQGVPRET GFDITAASEM 200
    MAILCLSESL HNLKKRIGRI VVGYTYEKKP VTVDQLGFTG AITLLLKDAI 250
    KPNLVQTLDH TPAIIHGGPF ANIAHGCNSV LATQIALKTS DYTVTECGFG 300
    ADLGAEKFLD IKRPVLGETP NAVVIVATAR ALKLNGGADK DELTKEDIPA 350
    LEKGMANLRR HVENMQKYNL PIVVAINHFN SDTEAEIKTI QDACAEMGVK 400
    AIEVDAWAKG GQGTQDLAKE VVKLADEELE FHELYKNSDS IEDKLSAIAT 450
    KIYGAKRVVL SKKAKRQIKT FNEQGWNDLP VCIAKTQYSF TDDQTKLGAP 500
    TDFDFHIRDL VPKLGAGFIV ALSGTMMTMP GLAKHPAAEN MDIDDNGQIA 550
    GLF 553
    Length:553
    Mass (Da):59,847
    Last modified:March 1, 2005 - v1
    Checksum:i09FF57B54CB4EEF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000033 Genomic DNA. Translation: AAV43379.1.
    RefSeqiYP_194410.1. NC_006814.3.

    Genome annotation databases

    EnsemblBacteriaiAAV43379; AAV43379; LBA1562.
    GeneIDi3251186.
    KEGGilac:LBA1562.
    PATRICi22198142. VBILacAci7974_1484.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000033 Genomic DNA. Translation: AAV43379.1 .
    RefSeqi YP_194410.1. NC_006814.3.

    3D structure databases

    ProteinModelPortali Q5FIU5.
    SMRi Q5FIU5. Positions 4-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272621.LBA1562.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV43379 ; AAV43379 ; LBA1562 .
    GeneIDi 3251186.
    KEGGi lac:LBA1562.
    PATRICi 22198142. VBILacAci7974_1484.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700396 / NCK56 / N2 / NCFM.

    Entry informationi

    Entry nameiFTHS2_LACAC
    AccessioniPrimary (citable) accession number: Q5FIU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3