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Q5FIQ9 (SYR_LACAC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:LBA1600
OrganismLactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) [Complete proteome] [HAMAP]
Taxonomic identifier272621 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242034

Regions

Motif119 – 12911"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q5FIQ9 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: B08F37DFBB05D8B8

FASTA56163,314
        10         20         30         40         50         60 
MDFKNEVVDL VSSQVDLPKE KITALIERPK NAKMGDYAFP AFILAKTMHK NPAIIAKDIA 

        70         80         90        100        110        120 
ENLNSDNFAN IQAVGPYVNF AIDHEKLIAS TLKDVLAEKE HYGDQKLGEG NVPIDMSSPN 

       130        140        150        160        170        180 
IAKPMSMGHL RSTVIGNSIA KTMKKVGYTP IKINYLGDYG TQFGKLIAAY KHWGNEEDVK 

       190        200        210        220        230        240 
KDPIMSLFHY YVKFHKEAEN NPELDNEGRE WFKKLEDGDP EAVELWKWFR EVSLKDFKRI 

       250        260        270        280        290        300 
YKELGVTFDS YNGEAFFNDK MQPVIDELKD KGLLHESRGA QVVDMGEDEN PAIIVKSDGT 

       310        320        330        340        350        360 
SIYLTRDLAA AEWRMKEYNF VKMLYVVGNE QAQHFVELKT VLKKMGYDWA DEIHHVPFGL 

       370        380        390        400        410        420 
ITQGGKKLST RKGNVVFLDQ VLRDAVNLAK KQIQEKNPDL ADQDQVAHDV GVGAVVFHDL 

       430        440        450        460        470        480 
KNDRLDNFDF DLDEVVRFEG DTGPYVQYTN ARAQSVLRKA AAMGEKPSEG DFNINDDWAF 

       490        500        510        520        530        540 
AVAKDLADFP RIVARSAEKF EPSVIAKFAL DLAKKFNKYY ANVKILTKDD QIGARLALVQ 

       550        560 
ATSIVLTESL RLLGVNAPKE M 

« Hide

References

[1]"Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM."
Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L., McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S., Hamrick A., Cano R., Klaenhammer T.R.
Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700396 / NCK56 / N2 / NCFM.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000033 Genomic DNA. Translation: AAV43415.1.
RefSeqYP_194446.1. NC_006814.3.

3D structure databases

ProteinModelPortalQ5FIQ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272621.LBA1600.

Proteomic databases

PRIDEQ5FIQ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV43415; AAV43415; LBA1600.
GeneID3251223.
KEGGlac:LBA1600.
PATRIC22198215. VBILacAci7974_1520.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247211.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_LACAC
AccessionPrimary (citable) accession number: Q5FIQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2005
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries