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Q5FHK5

- PNP_EHRRG

UniProt

Q5FHK5 - PNP_EHRRG

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Ehrlichia ruminantium (strain Gardel)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi494 – 4941MagnesiumUniRule annotation
Metal bindingi500 – 5001MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciERUM302409:GHVW-377-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:ERGA_CDS_03570
OrganismiEhrlichia ruminantium (strain Gardel)
Taxonomic identifieri302409 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000000533: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 789789Polyribonucleotide nucleotidyltransferasePRO_0000329632Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi302409.ERGA_CDS_03570.

Structurei

3D structure databases

ProteinModelPortaliQ5FHK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini561 – 62060KHUniRule annotationAdd
BLAST
Domaini630 – 69768S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FHK5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFNLIRKSTE WGGKTLVLES GKIARQANGA VVVTYGGTTV LSTVVAGKAK
60 70 80 90 100
EPVDFLPLTV QFVAKSYAVG KIPGGFLKRE GKPSDRETLI SRLIDRSIRP
110 120 130 140 150
LFPSGFYDEV SIVCNLLSYD TVTPPEVTAL IGATAALAIS GVPFNGMVVG
160 170 180 190 200
ARVGYLLSED KYLLNASADE MLSSSLDLFL SGNKDSVLMV ESEASELSES
210 220 230 240 250
QMLAAISFGH QNCQEVIKLI EEFREESGIL PFGFIPHDIT SLVDDIASSY
260 270 280 290 300
TESFSIAYSN IVKKERVLEL EKLRDQVLSD MLAKYEQPNG NLQCQYSSQD
310 320 330 340 350
IISALKSFER SLVRSKIIET SSRIDGRAFN GIRDIEIEID VLPKTHGSAL
360 370 380 390 400
FTRGNTQALV VTALGTPQDE QIVDDLDGDR RENFLLHYNF PPYAVGESAA
410 420 430 440 450
LRAPGRREIG HGKLAWKAIR YVLPEKSDFP YTIRVVSEIT ESDGSSSMAT
460 470 480 490 500
VCGASLALMD TGVPIKAPVA GIAMGLIKEG EKFIILSDIL GDEDHLGDMD
510 520 530 540 550
FKVAGTSSGI TALQMDMKIS GISIEVIEKS LLQAKDGRMH ILDKMNLVIQ
560 570 580 590 600
ESRECIKNHA PRIESIFINK DKIRNVIGSG GKNIREICEK TGARVEIMQD
610 620 630 640 650
GTVMIYAINN DAVEYAKNMI MDIVSEPEIG KVFDGTVIEI VKFGAFVSFL
660 670 680 690 700
GGKRGLIHIS EIKNEHINAV GSVISVNDKV KVLVIGIDRE YVQLSMRRVD
710 720 730 740 750
QETGEPIDGE LYNIRKTNSD SDDSFLSSGS VNNRHGSEKK RRGSGRSRRS
760 770 780
SGGSSYHRDD LHNNGFGNGN RSFNDNRNGN EVPRKPRFF
Length:789
Mass (Da):86,507
Last modified:March 1, 2005 - v1
Checksum:iE9CC451A1AE0BB20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925677 Genomic DNA. Translation: CAI27809.1.
RefSeqiWP_011255504.1. NC_006831.1.
YP_196283.1. NC_006831.1.

Genome annotation databases

EnsemblBacteriaiCAI27809; CAI27809; ERGA_CDS_03570.
GeneIDi3267816.
KEGGierg:ERGA_CDS_03570.
PATRICi20578440. VBIEhrRum72196_0381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925677 Genomic DNA. Translation: CAI27809.1 .
RefSeqi WP_011255504.1. NC_006831.1.
YP_196283.1. NC_006831.1.

3D structure databases

ProteinModelPortali Q5FHK5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 302409.ERGA_CDS_03570.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI27809 ; CAI27809 ; ERGA_CDS_03570 .
GeneIDi 3267816.
KEGGi erg:ERGA_CDS_03570.
PATRICi 20578440. VBIEhrRum72196_0381.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ERUM302409:GHVW-377-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Gardel.

Entry informationi

Entry nameiPNP_EHRRG
AccessioniPrimary (citable) accession number: Q5FHK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2005
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3