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Q5FHG5

- SYL_EHRRG

UniProt

Q5FHG5 - SYL_EHRRG

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Ehrlichia ruminantium (strain Gardel)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei595 – 5951ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciERUM302409:GHVW-318-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:ERGA_CDS_03010
    OrganismiEhrlichia ruminantium (strain Gardel)
    Taxonomic identifieri302409 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000000533: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 830830Leucine--tRNA ligasePRO_0000334754Add
    BLAST

    Proteomic databases

    PRIDEiQ5FHG5.

    Interactioni

    Protein-protein interaction databases

    STRINGi302409.ERGA_CDS_03010.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FHG5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi34 – 4411"HIGH" regionAdd
    BLAST
    Motifi592 – 5965"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FHG5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHYDFKEVER DVQEKWDFTV NVKDVQCYVL EMFPYPSGNI HMGHLRNYTI    50
    GDVIARYKRA CGLHVFHPIG WDAFGLPAEN AALSYNISPQ VWTRKNIDNM 100
    RSQLKSIGLS YNWDKEFATC DAEYYKYEQE FFLDFLKYGL AYRKESLVNW 150
    DPVDQTVLAN EQVIDGRGWR SGAIIEKRKL SQWFLKITDF AAELLDDLKS 200
    LNQWPEKVKL MQERWIGKSE GVIIDFQIVG INEVLQVFTT SPHTLFGASF 250
    IAVSFDHPIL KYVNDVQLIQ LIDSFDRKDL IDDSSINTVE KFGINSGLVA 300
    KHPLLDMDLP IYVANFVLMN YGTGAVFCCP AHDQRDFDFA KKYSLPIRQV 350
    IFPEQNVDLE REAYVGSGIM GCSGFLDGMT VDDAKKSMIE KLISLGICKK 400
    QVYYRLHDWG ISRQRYWGCP IPIIYCKKCG IVPVDKKDLP ITLPEDIDFT 450
    KSGNPLDNHP TWKYTKCPSC GADAKRETDT FDTFFESSWY FAAFCGIGKG 500
    IDKDVCNKLL PVDYYIGGIE HAVLHLLYSR FFCRALTRCG YFDVKEPFSS 550
    LITQGMVCHS TYLDKYGNYL FPEDGKKMIQ EGKYVTVGRA EKMSKSKKNV 600
    VHLDDIIDKY GADSARLFIL SDTPPERDIE WLDENIEGVS RYLNKLWKMI 650
    VDYDQIEQNF VFNDISNDAV EYRMNVHKIL NDITNDLEFY RFNCAVAKFR 700
    ELSNVISEMI RLSINHHVVS EAIYILIRVV EPFIPHIAEK LWQIVGGQGM 750
    LCNQLWPKVD SQLLIKKNVN IVVQVNGKFI KAVSVPNDID DDTLKSIALE 800
    VAQRRIGNSS VKNIYIIPAR VINIVITKSS 830
    Length:830
    Mass (Da):95,394
    Last modified:March 1, 2005 - v1
    Checksum:i39F0E588B3039040
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925677 Genomic DNA. Translation: CAI27753.1.
    RefSeqiYP_196227.1. NC_006831.1.

    Genome annotation databases

    EnsemblBacteriaiCAI27753; CAI27753; ERGA_CDS_03010.
    GeneIDi3268616.
    KEGGierg:ERGA_CDS_03010.
    PATRICi20578312. VBIEhrRum72196_0320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925677 Genomic DNA. Translation: CAI27753.1 .
    RefSeqi YP_196227.1. NC_006831.1.

    3D structure databases

    ProteinModelPortali Q5FHG5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 302409.ERGA_CDS_03010.

    Proteomic databases

    PRIDEi Q5FHG5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI27753 ; CAI27753 ; ERGA_CDS_03010 .
    GeneIDi 3268616.
    KEGGi erg:ERGA_CDS_03010.
    PATRICi 20578312. VBIEhrRum72196_0320.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ERUM302409:GHVW-318-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
      Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
      J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Gardel.

    Entry informationi

    Entry nameiSYL_EHRRG
    AccessioniPrimary (citable) accession number: Q5FHG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3