Q5FHG1 (SURE_EHRRG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	ERGA_CDS_03050

Organism

Ehrlichia ruminantium (strain Gardel) [Complete proteome] [HAMAP]

Taxonomic identifier

302409 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.
Sequence caution	The sequence CAI27757.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235614
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	42	1	Divalent metal cation By similarity
	Metal binding	94	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5FHG1 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: F1BA67EC9FA6AD06	FASTA	252	27,612
	10 20 30 40 50 60 MRVLLSNDDG FHANGIKALK EIVIKSGIAS EIWVVAPLNN CSGSGRSVGL NVKVQVSKVS 70 80 90 100 110 120 DTEFIVDSTP STSVFLALRK IMNYKPDLIL SGINHGVNIG NDVWYSGTVA AAAEGAAINI 130 140 150 160 170 180 PSIAISQEYD NKSGEINWVN PQRFLKQIIE MLVNVSFWNK STVMNVNFPL MPAKGIKFTD 190 200 210 220 230 240 QGKYVPCNEI EKNESSDDSN VSYTITRITP NKKNRAQCDG SIKAIDEGYI TITPLKFDMT 250 DFDVLTSLNS LK

References

[1]

"Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity." Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D. J. Bacteriol. 188:2533-2542(2006) [PubMed: 16547041] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Gardel.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR925677 Genomic DNA. Translation: CAI27757.1. Different initiation.
RefSeq	YP_196231.1. NC_006831.1.
3D structure databases
ProteinModelPortal	Q5FHG1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5FHG1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3268788.
GenomeReviews	Gene locus ERGA_CDS_03050 in contig CR925677_GR.
KEGG	erg:ERGA_CDS_03050.
PATRIC	20578320. VBIEhrRum72196_0324.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0496.
HOGENOM	HBG600532.
OMA	EVWTVAP.
PhylomeDB	Q5FHG1.
ProtClustDB	CLSK749108.
Enzyme and pathway databases
BioCyc	ERUM302409:ERGA_CDS_03050-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_EHRRG

Accession

Primary (citable) accession number: Q5FHG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	January 25, 2012
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program