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Q5FH87 (SYR_EHRRG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:ERGA_CDS_05040
OrganismEhrlichia ruminantium (strain Gardel) [Complete proteome] [HAMAP]
Taxonomic identifier302409 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence CAI27956.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242019

Regions

Motif132 – 14211"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q5FH87 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: DCB7B35A2B8AE584

FASTA57665,365
        10         20         30         40         50         60 
MSVACTIRRH IIEKLHVLNI DNFVVTNESI LAKLIVDYPN NPDHGDLYTN AALILSKYIK 

        70         80         90        100        110        120 
KNPMDIAKIL VDEFSSIKEI SDINVVKPGF INFNISLDVW YEIIISINRL KEKFGHVNFG 

       130        140        150        160        170        180 
NGKRVNIEFV SANPTGPMHI GHARGAIFGD VLANLLERVG YEVVREYYIN DAGAQVDVLV 

       190        200        210        220        230        240 
ESVYLRYKEV LGENIVIGSG LYPGLYLKDI GKLLYQEYGS GLLGMDYSQR RRIIRDVSLM 

       250        260        270        280        290        300 
YLMKLIKEDL ALLGIKHDIF TSESQLQKDN IVQKCVELLQ EKQLIYYGTL DQPKGTEGIN 

       310        320        330        340        350        360 
WKPRTQMLFK STDFGDDVDR ALQKADGSWT YFANDIAYHF YKISRGFQHM ILELGSDHIG 

       370        380        390        400        410        420 
YVKRLKAAVK ALSDGNATID IKLHSIVNFL DNGAQVKMSK RSGEFLTIKD VIEKVGKDVV 

       430        440        450        460        470        480 
RFIMLTRKSD VVLDFDFAKV VEQSKNNPVF YVQYAHARVH SLIRNAPKIL EIELVDFSVL 

       490        500        510        520        530        540 
SSKEEILLIK LLAKWQDIVE ISAKTAEPHR ITFYLIEVAE AFHALWGYGN KSTDMRFIVD 

       550        560        570 
NNINLTSARI YLAKSVGYVI ASGLTIFSIV PLTEMK 

« Hide

References

[1]"Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Gardel.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR925677 Genomic DNA. Translation: CAI27956.1. Different initiation.
RefSeqYP_196430.1. NC_006831.1.

3D structure databases

ProteinModelPortalQ5FH87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING302409.ERGA_CDS_05040.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI27956; CAI27956; ERGA_CDS_05040.
GeneID3268732.
KEGGerg:ERGA_CDS_05040.
PATRIC20578768. VBIEhrRum72196_0539.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMALCNVLAK.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycERUM302409:GHVW-531-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_EHRRG
AccessionPrimary (citable) accession number: Q5FH87
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: May 14, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries