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Q5FH87

- SYR_EHRRG

UniProt

Q5FH87 - SYR_EHRRG

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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Ehrlichia ruminantium (strain Gardel)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciERUM302409:GHVW-531-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:ERGA_CDS_05040
OrganismiEhrlichia ruminantium (strain Gardel)
Taxonomic identifieri302409 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000000533: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Arginine--tRNA ligasePRO_0000242019Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi302409.ERGA_CDS_05040.

Structurei

3D structure databases

ProteinModelPortaliQ5FH87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi132 – 14211"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247214.
KOiK01887.
OMAiLCNVLAK.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FH87-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVACTIRRH IIEKLHVLNI DNFVVTNESI LAKLIVDYPN NPDHGDLYTN
60 70 80 90 100
AALILSKYIK KNPMDIAKIL VDEFSSIKEI SDINVVKPGF INFNISLDVW
110 120 130 140 150
YEIIISINRL KEKFGHVNFG NGKRVNIEFV SANPTGPMHI GHARGAIFGD
160 170 180 190 200
VLANLLERVG YEVVREYYIN DAGAQVDVLV ESVYLRYKEV LGENIVIGSG
210 220 230 240 250
LYPGLYLKDI GKLLYQEYGS GLLGMDYSQR RRIIRDVSLM YLMKLIKEDL
260 270 280 290 300
ALLGIKHDIF TSESQLQKDN IVQKCVELLQ EKQLIYYGTL DQPKGTEGIN
310 320 330 340 350
WKPRTQMLFK STDFGDDVDR ALQKADGSWT YFANDIAYHF YKISRGFQHM
360 370 380 390 400
ILELGSDHIG YVKRLKAAVK ALSDGNATID IKLHSIVNFL DNGAQVKMSK
410 420 430 440 450
RSGEFLTIKD VIEKVGKDVV RFIMLTRKSD VVLDFDFAKV VEQSKNNPVF
460 470 480 490 500
YVQYAHARVH SLIRNAPKIL EIELVDFSVL SSKEEILLIK LLAKWQDIVE
510 520 530 540 550
ISAKTAEPHR ITFYLIEVAE AFHALWGYGN KSTDMRFIVD NNINLTSARI
560 570
YLAKSVGYVI ASGLTIFSIV PLTEMK
Length:576
Mass (Da):65,365
Last modified:June 27, 2006 - v2
Checksum:iDCB7B35A2B8AE584
GO

Sequence cautioni

The sequence CAI27956.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925677 Genomic DNA. Translation: CAI27956.1. Different initiation.
RefSeqiYP_196430.1. NC_006831.1.

Genome annotation databases

EnsemblBacteriaiCAI27956; CAI27956; ERGA_CDS_05040.
GeneIDi3268732.
KEGGierg:ERGA_CDS_05040.
PATRICi20578768. VBIEhrRum72196_0539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925677 Genomic DNA. Translation: CAI27956.1 . Different initiation.
RefSeqi YP_196430.1. NC_006831.1.

3D structure databases

ProteinModelPortali Q5FH87.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 302409.ERGA_CDS_05040.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI27956 ; CAI27956 ; ERGA_CDS_05040 .
GeneIDi 3268732.
KEGGi erg:ERGA_CDS_05040.
PATRICi 20578768. VBIEhrRum72196_0539.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247214.
KOi K01887.
OMAi LCNVLAK.
OrthoDBi EOG6JB13C.

Enzyme and pathway databases

BioCyci ERUM302409:GHVW-531-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00123. Arg_tRNA_synth.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Gardel.

Entry informationi

Entry nameiSYR_EHRRG
AccessioniPrimary (citable) accession number: Q5FH87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: October 29, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3