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Q5FH27

- ASSY_EHRRG

UniProt

Q5FH27 - ASSY_EHRRG

Protein

Argininosuccinate synthase

Gene

argG

Organism
Ehrlichia ruminantium (strain Gardel)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei85 – 851CitrullineUniRule annotation
    Binding sitei90 – 901CitrullineUniRule annotation
    Binding sitei115 – 1151ATP; via amide nitrogenUniRule annotation
    Binding sitei117 – 1171AspartateUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei121 – 1211CitrullineUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei125 – 1251CitrullineUniRule annotation
    Binding sitei176 – 1761CitrullineUniRule annotation
    Binding sitei185 – 1851CitrullineUniRule annotation
    Binding sitei261 – 2611CitrullineUniRule annotation
    Binding sitei273 – 2731CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 159ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciERUM302409:GHVW-406-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:ERGA_CDS_03850
    OrganismiEhrlichia ruminantium (strain Gardel)
    Taxonomic identifieri302409 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000000533: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Argininosuccinate synthasePRO_0000263925Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi302409.ERGA_CDS_03850.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FH27.
    SMRiQ5FH27. Positions 3-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FH27-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKIVLAYSG GLDTSVILKW LQENYNCEVV VFTADIGQED DMSVIQKKAA    50
    ALNVKEIFIE DLKEEFVRDF VFPMFRANTI YEGYYLLGTS IARPLIAKRQ 100
    IEIAHLTGAD AVAHGATGKG NDQVRFEFGY YCCDPNIKVI APWRQWELTS 150
    RHSLIEYARK NNINVPLDKV NEPPYSIDAN LLHISYEGKS LEDPYVEPDY 200
    TMLSRSLTPE LASSIPEYIE ITFEQGDPIA INDIPLSPAN LLHQLNKIGG 250
    KHGIGIVDIV ENRYIGIKSR GIYETPGGTI LLHAHRAIES ITLDRESAHL 300
    KDEIMPKYAK LIYNGYWWTT ERKMLQSLID NHKKKFNGTV RIKLYKGSVV 350
    VVGRKSNNSL YSYNLASFDS ESQGYDHKDA EGFIKVNSLR LKKS 394
    Length:394
    Mass (Da):44,673
    Last modified:March 1, 2005 - v1
    Checksum:i6778BFEC73A33D1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925677 Genomic DNA. Translation: CAI27837.1.
    RefSeqiWP_011255525.1. NC_006831.1.
    YP_196311.1. NC_006831.1.

    Genome annotation databases

    EnsemblBacteriaiCAI27837; CAI27837; ERGA_CDS_03850.
    GeneIDi3268229.
    KEGGierg:ERGA_CDS_03850.
    PATRICi20578504. VBIEhrRum72196_0412.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925677 Genomic DNA. Translation: CAI27837.1 .
    RefSeqi WP_011255525.1. NC_006831.1.
    YP_196311.1. NC_006831.1.

    3D structure databases

    ProteinModelPortali Q5FH27.
    SMRi Q5FH27. Positions 3-393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 302409.ERGA_CDS_03850.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI27837 ; CAI27837 ; ERGA_CDS_03850 .
    GeneIDi 3268229.
    KEGGi erg:ERGA_CDS_03850.
    PATRICi 20578504. VBIEhrRum72196_0412.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci ERUM302409:GHVW-406-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
      Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
      J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Gardel.

    Entry informationi

    Entry nameiASSY_EHRRG
    AccessioniPrimary (citable) accession number: Q5FH27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3