Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate--tRNA ligase 2

Gene

gltX2

Organism
Ehrlichia ruminantium (strain Gardel)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei241ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciERUM302409:G1GJ9-463-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 2UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 2UniRule annotation
Short name:
GluRS 2UniRule annotation
Gene namesi
Name:gltX2UniRule annotation
Ordered Locus Names:ERGA_CDS_04420
OrganismiEhrlichia ruminantium (strain Gardel)
Taxonomic identifieri302409 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
Proteomesi
  • UP000000533 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001195591 – 470Glutamate--tRNA ligase 2Add BLAST470

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5FGW4
SMRiQ5FGW4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 21"HIGH" regionUniRule annotationAdd BLAST11
Motifi238 – 242"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.3501 hit
3.40.50.6201 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q5FGW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNHVVTRFA PSPTGHLHLG GARTALFNWL YAKHNNGKFL LRIEDTDSKR
60 70 80 90 100
SSKELIDSII NSMIWLNIQH DGEIILQSSR ISRHIEIANQ LILNDKAYYC
110 120 130 140 150
YCSEEEINLE KEQYTKKGLH YKHNCIWKNR KPPTGNCSKV IRLHSDTEGI
160 170 180 190 200
TEFKDKVYGT IAVNNVQLDD MVLLRSNNTP TYLLSVVVDD YDMGITHIIR
210 220 230 240 250
GTDHLTNTAR QLLIYNALGW KPPEFAHIPL IHDENGNKLS KRHHALGIHE
260 270 280 290 300
YKNAGILPEA LVNYLLRMGW SHGNDELITI DEAIRWFSID KVGQSPAGLD
310 320 330 340 350
SKKLEFLNNH YINTTNNATI IEMIIPIIEK TIGYKVNTEK IGYLLNGINE
360 370 380 390 400
LKKRTKNLVN LANESLFYVE DIPISFDQES LIIIKSNHDI LSILYDNLSK
410 420 430 440 450
VLNDDWNNST LTSMIKNIVK DYNTKIHNIY HCLRASIIGR INAPSIIDIM
460 470
VNFQREECLN RIKYARDMVK
Length:470
Mass (Da):54,027
Last modified:March 1, 2005 - v1
Checksum:i2EB340613995DC37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925677 Genomic DNA Translation: CAI27894.1
RefSeqiWP_011255571.1, NC_006831.1

Genome annotation databases

EnsemblBacteriaiCAI27894; CAI27894; ERGA_CDS_04420
KEGGierg:ERGA_CDS_04420

Similar proteinsi

Entry informationi

Entry nameiSYE2_EHRRG
AccessioniPrimary (citable) accession number: Q5FGW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2005
Last modified: February 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome