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Q5FGT9

- MDH_EHRRG

UniProt

Q5FGT9 - MDH_EHRRG

Protein

Malate dehydrogenase

Gene

mdh

Organism
Ehrlichia ruminantium (strain Gardel)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391NADUniRule annotation
    Binding sitei88 – 881SubstrateUniRule annotation
    Binding sitei94 – 941SubstrateUniRule annotation
    Binding sitei101 – 1011NADUniRule annotation
    Binding sitei126 – 1261SubstrateUniRule annotation
    Binding sitei157 – 1571SubstrateUniRule annotation
    Active sitei181 – 1811Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 206NADUniRule annotation
    Nucleotide bindingi124 – 1263NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciERUM302409:GHVW-442-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:ERGA_CDS_04180
    OrganismiEhrlichia ruminantium (strain Gardel)
    Taxonomic identifieri302409 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000000533: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Malate dehydrogenasePRO_0000113450Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi302409.ERGA_CDS_04180.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FGT9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiFVINVAN.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5FGT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRDMMIQSKK IALIGSGNIG GMIAYLIRLK NLGDVVLLDI NDGMAKGKAL    50
    DIAESSPIGK YNGEIFGTNN YADIENADAI IVTAGITRKP GMSRDDLIST 100
    NVNIIKEIAT NIAKYAPNAF VIVVTNPLDV MVLAMYRYSH LPSNMIVGMA 150
    GVLDSARFSY FIAKELNVSV ESVDSLVLGG HGDIMLPLIR YSSVSGVSIA 200
    DLIKLGMITH DKVTEIVERT RKGGEEIVSL LKTGSAYYAP AESAVLMLDS 250
    YLNDKKLMLP CSAYLKGEYG VHDLFVGVPI IIGKNGVEKI VELQLTEEEN 300
    SIFNNSVALI QNLVANI 317
    Length:317
    Mass (Da):34,263
    Last modified:March 1, 2005 - v1
    Checksum:i8774003F1FA8CADE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925677 Genomic DNA. Translation: CAI27870.1.
    RefSeqiYP_196344.1. NC_006831.1.

    Genome annotation databases

    EnsemblBacteriaiCAI27870; CAI27870; ERGA_CDS_04180.
    GeneIDi3268598.
    KEGGierg:ERGA_CDS_04180.
    PATRICi20578578. VBIEhrRum72196_0447.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925677 Genomic DNA. Translation: CAI27870.1 .
    RefSeqi YP_196344.1. NC_006831.1.

    3D structure databases

    ProteinModelPortali Q5FGT9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 302409.ERGA_CDS_04180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI27870 ; CAI27870 ; ERGA_CDS_04180 .
    GeneIDi 3268598.
    KEGGi erg:ERGA_CDS_04180.
    PATRICi 20578578. VBIEhrRum72196_0447.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi FVINVAN.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci ERUM302409:GHVW-442-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
      Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
      J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Gardel.

    Entry informationi

    Entry nameiMDH_EHRRG
    AccessioniPrimary (citable) accession number: Q5FGT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3