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Q5FGT9 (MDH_EHRRG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:ERGA_CDS_04180
OrganismEhrlichia ruminantium (strain Gardel) [Complete proteome] [HAMAP]
Taxonomic identifier302409 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Malate dehydrogenase HAMAP-Rule MF_00487
PRO_0000113450

Regions

Nucleotide binding15 – 206NAD By similarity
Nucleotide binding124 – 1263NAD By similarity

Sites

Active site1811Proton acceptor By similarity
Binding site391NAD By similarity
Binding site881Substrate By similarity
Binding site941Substrate By similarity
Binding site1011NAD By similarity
Binding site1261Substrate By similarity
Binding site1571Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5FGT9 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 8774003F1FA8CADE

FASTA31734,263
        10         20         30         40         50         60 
MRDMMIQSKK IALIGSGNIG GMIAYLIRLK NLGDVVLLDI NDGMAKGKAL DIAESSPIGK 

        70         80         90        100        110        120 
YNGEIFGTNN YADIENADAI IVTAGITRKP GMSRDDLIST NVNIIKEIAT NIAKYAPNAF 

       130        140        150        160        170        180 
VIVVTNPLDV MVLAMYRYSH LPSNMIVGMA GVLDSARFSY FIAKELNVSV ESVDSLVLGG 

       190        200        210        220        230        240 
HGDIMLPLIR YSSVSGVSIA DLIKLGMITH DKVTEIVERT RKGGEEIVSL LKTGSAYYAP 

       250        260        270        280        290        300 
AESAVLMLDS YLNDKKLMLP CSAYLKGEYG VHDLFVGVPI IIGKNGVEKI VELQLTEEEN 

       310 
SIFNNSVALI QNLVANI 

« Hide

References

[1]"Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Gardel.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR925677 Genomic DNA. Translation: CAI27870.1.
RefSeqYP_196344.1. NC_006831.1.

3D structure databases

ProteinModelPortalQ5FGT9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING302409.ERGA_CDS_04180.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI27870; CAI27870; ERGA_CDS_04180.
GeneID3268598.
KEGGerg:ERGA_CDS_04180.
PATRIC20578578. VBIEhrRum72196_0447.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAFVGVPVI.
OrthoDBEOG6091FG.
ProtClustDBPRK06223.

Enzyme and pathway databases

BioCycERUM302409:GHVW-442-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_EHRRG
AccessionPrimary (citable) accession number: Q5FGT9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2005
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families