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Q5FGT9

- MDH_EHRRG

UniProt

Q5FGT9 - MDH_EHRRG

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Ehrlichia ruminantium (strain Gardel)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391NADUniRule annotation
Binding sitei88 – 881SubstrateUniRule annotation
Binding sitei94 – 941SubstrateUniRule annotation
Binding sitei101 – 1011NADUniRule annotation
Binding sitei126 – 1261SubstrateUniRule annotation
Binding sitei157 – 1571SubstrateUniRule annotation
Active sitei181 – 1811Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 206NADUniRule annotation
Nucleotide bindingi124 – 1263NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciERUM302409:GHVW-442-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:ERGA_CDS_04180
OrganismiEhrlichia ruminantium (strain Gardel)
Taxonomic identifieri302409 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000000533: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Malate dehydrogenasePRO_0000113450Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi302409.ERGA_CDS_04180.

Structurei

3D structure databases

ProteinModelPortaliQ5FGT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiFVINVAN.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5FGT9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDMMIQSKK IALIGSGNIG GMIAYLIRLK NLGDVVLLDI NDGMAKGKAL
60 70 80 90 100
DIAESSPIGK YNGEIFGTNN YADIENADAI IVTAGITRKP GMSRDDLIST
110 120 130 140 150
NVNIIKEIAT NIAKYAPNAF VIVVTNPLDV MVLAMYRYSH LPSNMIVGMA
160 170 180 190 200
GVLDSARFSY FIAKELNVSV ESVDSLVLGG HGDIMLPLIR YSSVSGVSIA
210 220 230 240 250
DLIKLGMITH DKVTEIVERT RKGGEEIVSL LKTGSAYYAP AESAVLMLDS
260 270 280 290 300
YLNDKKLMLP CSAYLKGEYG VHDLFVGVPI IIGKNGVEKI VELQLTEEEN
310
SIFNNSVALI QNLVANI
Length:317
Mass (Da):34,263
Last modified:March 1, 2005 - v1
Checksum:i8774003F1FA8CADE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR925677 Genomic DNA. Translation: CAI27870.1.
RefSeqiWP_011255552.1. NC_006831.1.
YP_196344.1. NC_006831.1.

Genome annotation databases

EnsemblBacteriaiCAI27870; CAI27870; ERGA_CDS_04180.
GeneIDi3268598.
KEGGierg:ERGA_CDS_04180.
PATRICi20578578. VBIEhrRum72196_0447.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR925677 Genomic DNA. Translation: CAI27870.1 .
RefSeqi WP_011255552.1. NC_006831.1.
YP_196344.1. NC_006831.1.

3D structure databases

ProteinModelPortali Q5FGT9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 302409.ERGA_CDS_04180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI27870 ; CAI27870 ; ERGA_CDS_04180 .
GeneIDi 3268598.
KEGGi erg:ERGA_CDS_04180.
PATRICi 20578578. VBIEhrRum72196_0447.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi FVINVAN.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci ERUM302409:GHVW-442-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Gardel.

Entry informationi

Entry nameiMDH_EHRRG
AccessioniPrimary (citable) accession number: Q5FGT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2005
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3