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Q5FG57 (SYH_EHRRG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidine--tRNA ligase

EC=6.1.1.21
Alternative name(s):
Histidyl-tRNA synthetase
Short name=HisRS
Gene names
Name:hisS
Ordered Locus Names:ERGA_CDS_07280
OrganismEhrlichia ruminantium (strain Gardel) [Complete proteome] [HAMAP]
Taxonomic identifier302409 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). HAMAP-Rule MF_00127

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00127.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

histidine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Histidine--tRNA ligase HAMAP-Rule MF_00127
PRO_0000136157

Sequences

Sequence LengthMass (Da)Tools
Q5FG57 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 6907FECEB2E473FF

FASTA41447,382
        10         20         30         40         50         60 
MQHNKLREVR GTKDLLDDEL YRFQYIQHLA QTIASRYGFI PVDTPIIEFT EVFTKLGNTS 

        70         80         90        100        110        120 
DIVTKEMYNF KDKAGEDITL RPEFTSAIVR LLISKNLTIP VKLFSSGPVF RYERPQKCRQ 

       130        140        150        160        170        180 
RQFHQINFEF FGSDSPIADV EMISLCYNIL SELKLSDRIK LEINFLGDQE TINSYKIHLV 

       190        200        210        220        230        240 
EYLNKYQKDL SEDSQRRLVV NPLRILDSKS PEDCKILLNA PSISDFYTQN SQNFFKEVLD 

       250        260        270        280        290        300 
GLDNLSINYV INHNIVRGLD YYCKTVFEFT TSELGSQNSV IAGGRYDGLV KSMGGHSTPA 

       310        320        330        340        350        360 
IGFAAGVERL SALIDYEHKK PKRIVLIPIG DDATSYAIKL AYELRCKGIH VCWNNYRGTS 

       370        380        390        400        410 
LKNELRKAND TDIVLIFGDE ELQSNTVKVK DMKTGDQQNV AVCDLLDNLL HRIV 

« Hide

References

[1]"Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Gardel.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR925677 Genomic DNA. Translation: CAI28180.1.
RefSeqYP_196654.1. NC_006831.1.

3D structure databases

ProteinModelPortalQ5FG57.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING302409.ERGA_CDS_07280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI28180; CAI28180; ERGA_CDS_07280.
GeneID3268584.
KEGGerg:ERGA_CDS_07280.
PATRIC20579250. VBIEhrRum72196_0774.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0124.
HOGENOMHOG000018072.
KOK01892.
OMACGGGNFK.
OrthoDBEOG6BPDH4.
ProtClustDBPRK00037.

Enzyme and pathway databases

BioCycERUM302409:GHVW-761-MONOMER.

Family and domain databases

Gene3D3.40.50.800. 1 hit.
HAMAPMF_00127. His_tRNA_synth.
InterProIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERPTHR11476. PTHR11476. 1 hit.
PfamPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMSSF52954. SSF52954. 1 hit.
TIGRFAMsTIGR00442. hisS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYH_EHRRG
AccessionPrimary (citable) accession number: Q5FG57
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2005
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries