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Q5FG57

- SYH_EHRRG

UniProt

Q5FG57 - SYH_EHRRG

Protein

Histidine--tRNA ligase

Gene

hisS

Organism
Ehrlichia ruminantium (strain Gardel)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. histidine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciERUM302409:GHVW-761-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidine--tRNA ligaseUniRule annotation (EC:6.1.1.21UniRule annotation)
    Alternative name(s):
    Histidyl-tRNA synthetaseUniRule annotation
    Short name:
    HisRSUniRule annotation
    Gene namesi
    Name:hisSUniRule annotation
    Ordered Locus Names:ERGA_CDS_07280
    OrganismiEhrlichia ruminantium (strain Gardel)
    Taxonomic identifieri302409 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000000533: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414Histidine--tRNA ligasePRO_0000136157Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi302409.ERGA_CDS_07280.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FG57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0124.
    HOGENOMiHOG000018072.
    KOiK01892.
    OMAiCGGGNFK.
    OrthoDBiEOG6BPDH4.

    Family and domain databases

    Gene3Di3.40.50.800. 1 hit.
    HAMAPiMF_00127. His_tRNA_synth.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view]
    PANTHERiPTHR11476. PTHR11476. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMiSSF52954. SSF52954. 1 hit.
    TIGRFAMsiTIGR00442. hisS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FG57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQHNKLREVR GTKDLLDDEL YRFQYIQHLA QTIASRYGFI PVDTPIIEFT    50
    EVFTKLGNTS DIVTKEMYNF KDKAGEDITL RPEFTSAIVR LLISKNLTIP 100
    VKLFSSGPVF RYERPQKCRQ RQFHQINFEF FGSDSPIADV EMISLCYNIL 150
    SELKLSDRIK LEINFLGDQE TINSYKIHLV EYLNKYQKDL SEDSQRRLVV 200
    NPLRILDSKS PEDCKILLNA PSISDFYTQN SQNFFKEVLD GLDNLSINYV 250
    INHNIVRGLD YYCKTVFEFT TSELGSQNSV IAGGRYDGLV KSMGGHSTPA 300
    IGFAAGVERL SALIDYEHKK PKRIVLIPIG DDATSYAIKL AYELRCKGIH 350
    VCWNNYRGTS LKNELRKAND TDIVLIFGDE ELQSNTVKVK DMKTGDQQNV 400
    AVCDLLDNLL HRIV 414
    Length:414
    Mass (Da):47,382
    Last modified:March 1, 2005 - v1
    Checksum:i6907FECEB2E473FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925677 Genomic DNA. Translation: CAI28180.1.
    RefSeqiWP_011255803.1. NC_006831.1.
    YP_196654.1. NC_006831.1.

    Genome annotation databases

    EnsemblBacteriaiCAI28180; CAI28180; ERGA_CDS_07280.
    GeneIDi3268584.
    KEGGierg:ERGA_CDS_07280.
    PATRICi20579250. VBIEhrRum72196_0774.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925677 Genomic DNA. Translation: CAI28180.1 .
    RefSeqi WP_011255803.1. NC_006831.1.
    YP_196654.1. NC_006831.1.

    3D structure databases

    ProteinModelPortali Q5FG57.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 302409.ERGA_CDS_07280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI28180 ; CAI28180 ; ERGA_CDS_07280 .
    GeneIDi 3268584.
    KEGGi erg:ERGA_CDS_07280.
    PATRICi 20579250. VBIEhrRum72196_0774.

    Phylogenomic databases

    eggNOGi COG0124.
    HOGENOMi HOG000018072.
    KOi K01892.
    OMAi CGGGNFK.
    OrthoDBi EOG6BPDH4.

    Enzyme and pathway databases

    BioCyci ERUM302409:GHVW-761-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.800. 1 hit.
    HAMAPi MF_00127. His_tRNA_synth.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR015807. His-tRNA-ligase.
    IPR004516. HisRS/HisZ.
    [Graphical view ]
    PANTHERi PTHR11476. PTHR11476. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001549. His-tRNA_synth. 1 hit.
    SUPFAMi SSF52954. SSF52954. 1 hit.
    TIGRFAMsi TIGR00442. hisS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
      Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
      J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Gardel.

    Entry informationi

    Entry nameiSYH_EHRRG
    AccessioniPrimary (citable) accession number: Q5FG57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3