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Q5FFX1 (Q5FFX1_EHRRG) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323 RuleBase RU000607
EC=4.99.1.1 HAMAP MF_00323 RuleBase RU000607
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323 EMBL CAI28092.1
Ordered Locus Names:ERGA_CDS_06400
OrganismEhrlichia ruminantium (strain Gardel) [Complete proteome] [HAMAP]
Taxonomic identifier302409 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323 RuleBase RU000607 SAAS SAAS001015

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323 RuleBase RU004185

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1941Iron By similarity HAMAP MF_00323
Metal binding2741Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
Q5FFX1 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: BA82434999FC75E5

FASTA31336,289
        10         20         30         40         50         60 
MSRIAVVLFN LGGPQSLSEV KSFLFNLFYD KNIINLPNPL RFIIATLISH FRNKTATKIY 

        70         80         90        100        110        120 
QYLDGKSPIL EATKTQATLL ETVLNKHNNN QYKVFIFMRY SNPSVKETIK HVNEYNPNRI 

       130        140        150        160        170        180 
ILLPLYPHYS LTTTFSAIQH WNKYTKTENL AIPTTTICSY YHNEHYIKAQ CKLITEKYYE 

       190        200        210        220        230        240 
ACIYGLPRIL FSAHSLPLSI IQRGDPYLYQ IEHSVYLIVK FLNIPSLDYK ICYQSKVGPV 

       250        260        270        280        290        300 
KWLEPSTLSE INKAIQNNTP IVLVPISFVS ENSETLVELD IEYKSTVPEN MFFRVPTLSE 

       310 
NEGYIKCLEE MCI

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References

[1]"Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
J. Bacteriol. 188:2533-2542(2006) [PubMed: 16547041] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR925677 Genomic DNA. Translation: CAI28092.1.
RefSeqYP_196566.1. NC_006831.1.

3D structure databases

ProteinModelPortalQ5FFX1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5FFX1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3268009.
GenomeReviewsGene locus ERGA_CDS_06400 in contig CR925677_GR.
KEGGerg:ERGA_CDS_06400.
PATRIC20579054. VBIEhrRum72196_0677.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMALLQMGGP.
PhylomeDBQ5FFX1.
ProtClustDBPRK00035.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5FFX1_EHRRG
AccessionPrimary (citable) accession number: Q5FFX1
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2005
Last sequence update: March 1, 2005
Last modified: December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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