Q5FFL4 (Q5FFL4_EHRRG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative Deoxyuridine 5-triphosphate nucleotidohydrolase EMBL CAI27986.1

Gene names

Name:	dut EMBL CAI27986.1
Ordered Locus Names:	ERGA_CDS_05340

Organism

Ehrlichia ruminantium (strain Gardel) [Complete proteome] [HAMAP]

Taxonomic identifier

302409 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Ehrlichia

Protein attributes

Sequence length	124 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. SAAS SAAS008181
Catalytic activity	dUTP + H2O = dUMP + diphosphate. SAAS SAAS008181
Cofactor	Magnesium By similarity. SAAS SAAS008181

Ontologies

Keywords
Biological process	Nucleotide metabolism SAAS SAAS008181
Ligand	Magnesium SAAS SAAS008181 Metal-binding SAAS SAAS008181
Molecular function	Hydrolase SAAS SAAS008181 EMBL CAI27986.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5FFL4 [UniParc]. Last modified March 1, 2005. Version 1. Checksum: F61D6CA0BEA4EDE5	FASTA	124	13,280
	10 20 30 40 50 60 MDLCSAVVSS IVLKPGCREC IKTGIAISVP DGYEAQIRPR SGLALKFGIT VLNTPGTIDA 70 80 90 100 110 120 DYRGEIMVIL INLGNEAYTI NYGDRIAQMV IAPVTHISWN LVEDLEANTT KRGIHGFGST GIST

References

[1]

"Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity." Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D. J. Bacteriol. 188:2533-2542(2006) [PubMed: 16547041] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR925677 Genomic DNA. Translation: CAI27986.1.
RefSeq	YP_196460.1. NC_006831.1.
3D structure databases
ProteinModelPortal	Q5FFL4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5FFL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3268421.
GenomeReviews	Gene locus ERGA_CDS_05340 in contig CR925677_GR.
KEGG	erg:ERGA_CDS_05340.
PATRIC	20578828. VBIEhrRum72196_0568.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0756.
HOGENOM	HBG436079.
OMA	IMVILIN.
PhylomeDB	Q5FFL4.
ProtClustDB	CLSK749155.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
KO	K01520.
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. Dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5FFL4_EHRRG

Accession

Primary (citable) accession number: Q5FFL4

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2005
Last sequence update:	March 1, 2005
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)