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Protein

Elongation factor Tu

Gene

tuf1

more
Organism
Ehrlichia ruminantium (strain Gardel)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPUniRule annotation
Nucleotide bindingi80 – 845GTPUniRule annotation
Nucleotide bindingi135 – 1384GTPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciERUM302409:GHVW-166-MONOMER.
ERUM302409:GHVW-661-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tuf1UniRule annotation
Synonyms:tufA
Ordered Locus Names:ERGA_CDS_01580
AND
Name:tuf2UniRule annotation
Synonyms:tuf
Ordered Locus Names:ERGA_CDS_06310
OrganismiEhrlichia ruminantium (strain Gardel)
Taxonomic identifieri302409 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
ProteomesiUP000000533 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Elongation factor TuPRO_0000337376Add
BLAST

Proteomic databases

PRIDEiQ5FFE6.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5FFE6.
SMRiQ5FFE6. Positions 6-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 205200tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 228G1By similarity
Regioni59 – 635G2By similarity
Regioni80 – 834G3By similarity
Regioni135 – 1384G4By similarity
Regioni173 – 1753G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5FFE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDGRKPHIN VGTIGHVDHG KTTLTAALTT VLAKRLSGEG NKSVKYDEID
60 70 80 90 100
KAPEEKARGI TISTAHVEYE TENRHYAHVD CPGHADYIKN MITGAAQMDA
110 120 130 140 150
AILVVSATDG AMPQTREHIL LAKQVGVKDI VVWMNKCDVV DDEEMLSLVE
160 170 180 190 200
MEIRELLTKY GYPGDDIDVV KGSAVKALEE ESADGVWSEK IMELMNALEK
210 220 230 240 250
IDLPIREKDK PFLMSIEDVF SIPGRGTVVT GRIERGVIKV GDKIDIVGLR
260 270 280 290 300
DIQSTVCTGV EMFHKALDAG EAGDNAGILL RGIKKEDVER GQVLSAPGQI
310 320 330 340 350
HSYKGFKAEV YVLKKEEGGR HTPFFSNYQP QFYVRTTDVT GNIKLPDGVE
360 370 380 390
MVMPGDNISI EVNLDKPVAI DKGLRFAIRE GGRTIGSGII TEILE
Length:395
Mass (Da):43,282
Last modified:March 1, 2005 - v1
Checksum:iC2B3B98AD64B94F0
GO

Sequence cautioni

The sequence CAI28083.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925677 Genomic DNA. Translation: CAI27610.1.
CR925677 Genomic DNA. Translation: CAI28083.1. Different initiation.
RefSeqiWP_011154850.1. NC_006831.1.

Genome annotation databases

EnsemblBacteriaiCAI27610; CAI27610; ERGA_CDS_01580.
CAI28083; CAI28083; ERGA_CDS_06310.
KEGGierg:ERGA_CDS_01580.
erg:ERGA_CDS_06310.
PATRICi20577991. VBIEhrRum72196_0169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR925677 Genomic DNA. Translation: CAI27610.1.
CR925677 Genomic DNA. Translation: CAI28083.1. Different initiation.
RefSeqiWP_011154850.1. NC_006831.1.

3D structure databases

ProteinModelPortaliQ5FFE6.
SMRiQ5FFE6. Positions 6-395.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5FFE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI27610; CAI27610; ERGA_CDS_01580.
CAI28083; CAI28083; ERGA_CDS_06310.
KEGGierg:ERGA_CDS_01580.
erg:ERGA_CDS_06310.
PATRICi20577991. VBIEhrRum72196_0169.

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OrthoDBiEOG6R5C6X.

Enzyme and pathway databases

BioCyciERUM302409:GHVW-166-MONOMER.
ERUM302409:GHVW-661-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
    Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
    J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Gardel.

Entry informationi

Entry nameiEFTU_EHRRG
AccessioniPrimary (citable) accession number: Q5FFE6
Secondary accession number(s): Q5FFT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2005
Last modified: July 22, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.