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Q5FFE6

- EFTU_EHRRG

UniProt

Q5FFE6 - EFTU_EHRRG

Protein

Elongation factor Tu

Gene

tuf1

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Organism
Ehrlichia ruminantium (strain Gardel)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2005)
      Previous versions | rss
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    • Comment

    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228GTPUniRule annotation
    Nucleotide bindingi80 – 845GTPUniRule annotation
    Nucleotide bindingi135 – 1384GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciERUM302409:GHVW-166-MONOMER.
    ERUM302409:GHVW-661-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tuf1UniRule annotation
    Synonyms:tufA
    Ordered Locus Names:ERGA_CDS_01580
    AND
    Name:tuf2UniRule annotation
    Synonyms:tuf
    Ordered Locus Names:ERGA_CDS_06310
    OrganismiEhrlichia ruminantium (strain Gardel)
    Taxonomic identifieri302409 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeEhrlichia
    ProteomesiUP000000533: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Elongation factor TuPRO_0000337376Add
    BLAST

    Proteomic databases

    PRIDEiQ5FFE6.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi302409.ERGA_CDS_06310.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5FFE6.
    SMRiQ5FFE6. Positions 6-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 205200tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 228G1By similarity
    Regioni59 – 635G2By similarity
    Regioni80 – 834G3By similarity
    Regioni135 – 1384G4By similarity
    Regioni173 – 1753G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0050.
    HOGENOMiHOG000229290.
    KOiK02358.
    OMAiGTEMCMP.
    OrthoDBiEOG6R5C6X.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5FFE6-1 [UniParc]FASTAAdd to Basket

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    MVDGRKPHIN VGTIGHVDHG KTTLTAALTT VLAKRLSGEG NKSVKYDEID    50
    KAPEEKARGI TISTAHVEYE TENRHYAHVD CPGHADYIKN MITGAAQMDA 100
    AILVVSATDG AMPQTREHIL LAKQVGVKDI VVWMNKCDVV DDEEMLSLVE 150
    MEIRELLTKY GYPGDDIDVV KGSAVKALEE ESADGVWSEK IMELMNALEK 200
    IDLPIREKDK PFLMSIEDVF SIPGRGTVVT GRIERGVIKV GDKIDIVGLR 250
    DIQSTVCTGV EMFHKALDAG EAGDNAGILL RGIKKEDVER GQVLSAPGQI 300
    HSYKGFKAEV YVLKKEEGGR HTPFFSNYQP QFYVRTTDVT GNIKLPDGVE 350
    MVMPGDNISI EVNLDKPVAI DKGLRFAIRE GGRTIGSGII TEILE 395
    Length:395
    Mass (Da):43,282
    Last modified:March 1, 2005 - v1
    Checksum:iC2B3B98AD64B94F0
    GO

    Sequence cautioni

    The sequence CAI28083.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925677 Genomic DNA. Translation: CAI27610.1.
    CR925677 Genomic DNA. Translation: CAI28083.1. Different initiation.
    RefSeqiYP_196084.1. NC_006831.1.
    YP_196557.2. NC_006831.1.

    Genome annotation databases

    EnsemblBacteriaiCAI27610; CAI27610; ERGA_CDS_01580.
    CAI28083; CAI28083; ERGA_CDS_06310.
    GeneIDi3268373.
    3268374.
    KEGGierg:ERGA_CDS_01580.
    erg:ERGA_CDS_06310.
    PATRICi20577991. VBIEhrRum72196_0169.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR925677 Genomic DNA. Translation: CAI27610.1 .
    CR925677 Genomic DNA. Translation: CAI28083.1 . Different initiation.
    RefSeqi YP_196084.1. NC_006831.1.
    YP_196557.2. NC_006831.1.

    3D structure databases

    ProteinModelPortali Q5FFE6.
    SMRi Q5FFE6. Positions 6-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 302409.ERGA_CDS_06310.

    Proteomic databases

    PRIDEi Q5FFE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI27610 ; CAI27610 ; ERGA_CDS_01580 .
    CAI28083 ; CAI28083 ; ERGA_CDS_06310 .
    GeneIDi 3268373.
    3268374.
    KEGGi erg:ERGA_CDS_01580.
    erg:ERGA_CDS_06310.
    PATRICi 20577991. VBIEhrRum72196_0169.

    Phylogenomic databases

    eggNOGi COG0050.
    HOGENOMi HOG000229290.
    KOi K02358.
    OMAi GTEMCMP.
    OrthoDBi EOG6R5C6X.

    Enzyme and pathway databases

    BioCyci ERUM302409:GHVW-166-MONOMER.
    ERUM302409:GHVW-661-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomic analysis of three strains of Ehrlichia ruminantium reveals an active process of genome size plasticity."
      Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y., Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.
      J. Bacteriol. 188:2533-2542(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Gardel.

    Entry informationi

    Entry nameiEFTU_EHRRG
    AccessioniPrimary (citable) accession number: Q5FFE6
    Secondary accession number(s): Q5FFT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3