Reviewed, UniProtKB/Swiss-Prot Q5FB27 (ADO_MACFA)

Names and origin

Protein names

Recommended name:
    Aldehyde oxidase
    EC=1.2.3.1

Gene names

Name:

AOX1

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	1338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An aldehyde + H(2)O + O(2) = a carboxylic acid + H(2)O(2).
Cofactor	Binds 2 2Fe-2S clusters By similarity. FAD By similarity. Molybdopterin By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the xanthine dehydrogenase family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 FAD-binding PCMH-type domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	2Fe-2S FAD Flavoprotein Iron Iron-sulfur Metal-binding Molybdenum NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW FAD binding Inferred from electronic annotation. Source: InterPro NAD binding Inferred from electronic annotation. Source: InterPro aldehyde oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro molybdenum ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1338	1338	Aldehyde oxidase		PRO_0000166105
Regions
	Domain	5 – 92	88	2Fe-2S ferredoxin-type
	Domain	236 – 421	186	FAD-binding PCMH-type
Sites
	Metal binding	44	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	49	1	Iron-sulfur (2Fe-2S) By similarity
	Metal binding	52	1	Iron-sulfur (2Fe-2S) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5FB27-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 0A3F07058DCADAD6	FASTA	1,338	147,713
	10 20 30 40 50 60 MDRASELLFY VNGRKVIEKN VDPETMLLPY LRKKLRLTGT KYGCGGGGCG ACTVMISRYN 70 80 90 100 110 120 PITNRIRHHP ANACLIPICS LYGTAVTTVE GIGSTHTRIH PVQERIAKCH GTQCGFCTPG 130 140 150 160 170 180 MVMSIYTLLR NHPEPTLDQL TDALGGNLCR CTGYRPIIDA CKTFCETSGC CQSKENGVCC 190 200 210 220 230 240 LDQGINGLPE FEEGSKTSPK LFAEEEFLPL DPTQELIFPP ELMIMAEKQP QRTRVFGSER 250 260 270 280 290 300 MMWFSPVTLK ELLEFKFKYP QAPVIMGNTS VGPQVKFKGV FHPGYNSPDR IEEPECCKPY 310 320 330 340 350 360 TYGLTLGAGL SLAQVKDILA DVVQKLPEEK TQTYHALLKH LGTLAGSQIR NMASLGGHII 370 380 390 400 410 420 SRHPDSDLNP ILAVGNCTLN LLSKEGKRQI PLNEQFLSKC PNADLKPQEI LVSVNIPYSR 430 440 450 460 470 480 KLEFVSAFRQ AQRQENALAI VNSGMRVFFG EGHGIIRELS ISYGGVGPAT ICAKNSCQKL 490 500 510 520 530 540 IGRHWNEEML DTACRLVLEE VSLSGSAPGG KVEFKRTLII SFLFKFYLEV SQILKKMDPI 550 560 570 580 590 600 HYPSLADKYE SALEDLHSKH HCSTLKYQHM GPKQHPEDPI GHPIMHLSGV KHATGEAIYC 610 620 630 640 650 660 DDMPPVDQEL FLTFVTSSRA HAKIVSIDLS EALSMPGVVD VITAEHLSDV NSFCFFTEAE 670 680 690 700 710 720 EFLATDKVFC VGQLVCAVLA DSEVQAKRAA KQVKIVYQDL EPLILTIKEA IQHNSFFEPE 730 740 750 760 770 780 RKLEYGNVDE AFKVVDQILE GEIHMGGQEH FYMETQSMLV VPKGEDQEMD VYVSTQFPKY 790 800 810 820 830 840 IQDIVASTLK LPANKVMCHV KRVGGAFGGK AFKTGVIAAV TAFAANKHGR AVRCVLERGE 850 860 870 880 890 900 DMLITGGRHP YLGKYKAGFM NDGRILALDM EHYSNAGNSL DESLLVIEMG LLKMDNAYKF 910 920 930 940 950 960 PNLRCRGWAC RTNLPSNTAF RGFGFPQAGL ITESCIMEVA AKCGLSPEKV RMINMYKEID 970 980 990 1000 1010 1020 QTPYKQEINA KNLIQCWREC MAVSSYSLRK AAVEKFNAEN YWKKKGLAMV PLKYPVGLGS 1030 1040 1050 1060 1070 1080 RAAGQAAALV HIYLDGSVLV THGGIEMGQG VHTKMIQVVS RELGMPISNV HLRGTSTETV 1090 1100 1110 1120 1130 1140 PNANVSGGSV VADLNGLAVK DACQILLKRL EPIISKNPKG TWKDWAQTAF DESISLSAIG 1150 1160 1170 1180 1190 1200 YFRGYESDIN WEKGEGHPFE YFVYGAACSE VEIDCLTGDH KNIRTDIVMD VGCSINPAID 1210 1220 1230 1240 1250 1260 IGQIEGAFIQ GMGLYTIEEL NYSPQGVLHT RGPDQYKIPA ICDTPTEFHI SLLPPSENSN 1270 1280 1290 1300 1310 1320 TLYSSKGLGE SGVFLGCSVF FAIHDAVSAA RRERGLHGPL TLNSPLTPEK IRMACEDKFT 1330 KMIPRDEPGS CVPWNVPV

References

[1]	"Molecular cloning and characterization of monkey aldehyde oxidase." Hoshino K. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB201545 mRNA. Translation: BAD89382.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q5FB27.
Family and domain databases
InterPro	IPR002888. 2Fe-2S_bd. IPR006058. 2Fe2S_fd_BS. IPR000674. Ald_Oxase/Xan_DHase_a/b. IPR016208. Ald_Oxase/xanthine_DHase. IPR014313. Aldehyde_oxidase. IPR008274. AldOxase/xan_DHase_Mopterin-bd. IPR012675. b-grasp_ferredoxin-like. IPR005107. CO_DHase_flav_C. IPR016169. CO_DHase_flavot_FAD-bd_sub2. IPR016167. FAD-bd_2_sub1. IPR001041. Ferredoxin. IPR002346. Mopterin_DHase_FAD-bd. IPR000572. OxRdtase_Mopterin-bd. [Graphical view]
Gene3D	G3DSA:3.30.365.10. Ald_xan_DH_mo_bd. 2 hits. G3DSA:3.90.1170.50. Aldxan_DH_hamm. 1 hit. G3DSA:3.30.390.50. CO_DH_flav_C. 1 hit. G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit. G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit. G3DSA:3.10.20.30. Ferredoxin_fold. 1 hit.
Pfam	PF01315. Ald_Xan_dh_C. 1 hit. PF02738. Ald_Xan_dh_C2. 1 hit. PF03450. CO_deh_flav_C. 1 hit. PF00941. FAD_binding_5. 1 hit. PF00111. Fer2. 1 hit. PF01799. Fer2_2. 1 hit. [Graphical view]
PIRSF	PIRSF000127. Xanthine_DH. 1 hit.
ProDom	PD186071. 2Fe-2S_bind. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR02969. mam_aldehyde_ox. 1 hit.
PROSITE	PS00197. 2FE2S_FER_1. 1 hit. PS51085. 2FE2S_FER_2. 1 hit. PS51387. FAD_PCMH. 1 hit. PS00559. MOLYBDOPTERIN_EUK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADO_MACFA

Accession

Primary (citable) accession number: Q5FB27

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	March 15, 2005
Last modified:	November 25, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)