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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.1 Publication

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.1 Publication

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei147May be catalytically importantBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BRENDAi3.5.4.16. 3590.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase 1B
Gene namesi
Name:folE2
Ordered Locus Names:NGO0387
OrganismiNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Taxonomic identifieri242231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000535 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477141 – 257GTP cyclohydrolase FolE2Add BLAST257

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 34Combined sources17
Beta strandi37 – 51Combined sources15
Helixi61 – 69Combined sources9
Helixi76 – 90Combined sources15
Beta strandi93 – 108Combined sources16
Turni110 – 112Combined sources3
Beta strandi115 – 129Combined sources15
Beta strandi132 – 146Combined sources15
Helixi148 – 153Combined sources6
Beta strandi154 – 156Combined sources3
Beta strandi160 – 173Combined sources14
Helixi177 – 185Combined sources9
Beta strandi188 – 191Combined sources4
Helixi198 – 210Combined sources13
Helixi215 – 228Combined sources14
Beta strandi232 – 241Combined sources10
Beta strandi246 – 256Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D2OX-ray2.04A/B1-257[»]
5K95X-ray2.77A/B1-257[»]
5K9GX-ray1.90A/B1-257[»]
ProteinModelPortaliQ5F9K6.
SMRiQ5F9K6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5F9K6.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.Curated

Phylogenomic databases

HOGENOMiHOG000280679.
KOiK09007.
OMAiINMYVDL.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5F9K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAIADVQSS RDLRNLPINQ VGIKDLRFPI TLKTAEGTQS TVARLTMTVY
60 70 80 90 100
LPAEQKGTHM SRFVALMEQH TEVLDFAQLH RLTAEMVALL DSRAGKISVS
110 120 130 140 150
FPFFRKKTAP VSGIRSLLDY DVSLTGEMKD GAYGHSMKVM IPVTSLCPCS
160 170 180 190 200
KEISQYGAHN QRSHVTVSLT SDAEVGIEEV IDYVETQASC QLYGLLKRPD
210 220 230 240 250
EKYVTEKAYE NPKFVEDMVR DVATSLIADK RIKSFVVESE NFESIHNHSA

YAYIAYP
Length:257
Mass (Da):28,747
Last modified:March 15, 2005 - v1
Checksum:iA0235399C3EDF2A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004969 Genomic DNA. Translation: AAW89131.1.
RefSeqiWP_003687811.1. NC_002946.2.
YP_207543.1. NC_002946.2.

Genome annotation databases

EnsemblBacteriaiAAW89131; AAW89131; NGO_0387.
GeneIDi3282560.
KEGGingo:NGO_0387.
PATRICi20333781. VBINeiGon24812_0468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004969 Genomic DNA. Translation: AAW89131.1.
RefSeqiWP_003687811.1. NC_002946.2.
YP_207543.1. NC_002946.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3D2OX-ray2.04A/B1-257[»]
5K95X-ray2.77A/B1-257[»]
5K9GX-ray1.90A/B1-257[»]
ProteinModelPortaliQ5F9K6.
SMRiQ5F9K6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW89131; AAW89131; NGO_0387.
GeneIDi3282560.
KEGGingo:NGO_0387.
PATRICi20333781. VBINeiGon24812_0468.

Phylogenomic databases

HOGENOMiHOG000280679.
KOiK09007.
OMAiINMYVDL.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BRENDAi3.5.4.16. 3590.

Miscellaneous databases

EvolutionaryTraceiQ5F9K6.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGCH4_NEIG1
AccessioniPrimary (citable) accession number: Q5F9K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: March 15, 2005
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.