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Q5F9J2 (PYRF_NEIG1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:NGO0401
OrganismNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090) [Reference proteome] [HAMAP]
Taxonomic identifier242231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
PRO_0000241878

Regions

Region71 – 8010Substrate binding By similarity

Sites

Active site731Proton donor By similarity
Binding site221Substrate By similarity
Binding site441Substrate By similarity
Binding site1301Substrate By similarity
Binding site1911Substrate By similarity
Binding site2011Substrate By similarity
Binding site2211Substrate; via amide nitrogen By similarity
Binding site2221Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5F9J2 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: B02D9E41AFB1EECA

FASTA24626,506
        10         20         30         40         50         60 
MNPLITDFQT PQQRTPVIVA LDFANEKDTL GFVRNLDPAL CQIKIGKELF TATGRSLAES 

        70         80         90        100        110        120 
LIHQGFKLFL DLKYHDIPHT VAQACKVAAD MGVWMVDMHA SGGRRMMEAA AEAVAGYGTK 

       130        140        150        160        170        180 
PLLIGVTVLT SMEQSDLAEI GLNTAPEEQV IRLAKLAQSS GLDGVVCSAQ EAAPLRRELG 

       190        200        210        220        230        240 
RDFVLVTPGI RLDVAGNNDD QRRIMTPAEA LAAGSTYLVM GRPVTRAADP VAVLREVNRV 


ANLEAN 

« Hide

References

[1]"The complete genome sequence of Neisseria gonorrhoeae."
Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. expand/collapse author list , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700825 / FA 1090.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004969 Genomic DNA. Translation: AAW89145.1.
RefSeqYP_207557.1. NC_002946.2.

3D structure databases

ProteinModelPortalQ5F9J2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING242231.NGO0401.

Proteomic databases

PRIDEQ5F9J2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW89145; AAW89145; NGO0401.
GeneID3283006.
KEGGngo:NGO0401.
PATRIC20333811. VBINeiGon24812_0483.

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226071.
KOK01591.
OMASAYHAIK.
OrthoDBEOG6N6815.

Enzyme and pathway databases

BioCycNGON242231:GI2G-380-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_NEIG1
AccessionPrimary (citable) accession number: Q5F9J2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways