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Q5F973

- PUR5_NEIG1

UniProt

Q5F973 - PUR5_NEIG1

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNGON242231:GI2G-504-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:NGO0526
    OrganismiNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
    Taxonomic identifieri242231 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000535: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258373Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi242231.NGO0526.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5F973.
    SMRiQ5F973. Positions 3-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiGEATCEV.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5F973-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTSLSYRDA GVGIDAGDQL VEKIKPFAKR TMRPEVLGDL GGFGALVEIG    50
    KKYQNPVLVS GTDGVGTKLK LAFDWDKHDT VGIDLVAMSV NDILVQGAEP 100
    LFFLDYFACG KLDVPRATDV IKGIAQGCEE SGCALIGGET AEMPGMYPVG 150
    EYDLAGFAVG VVEKENVITG LSIGAGDVVL GLASNGAHSN GYSLIRKIIE 200
    RDNPDLDAEF DNGKTLREAV IAPTRLYVKP ILAALEKFTI KGMAHITGGG 250
    ITENVPRVLP KNTVAQIDAE SWELPKLFQW LQKAGNVETQ EMYRTFNCGI 300
    GMVVIVAAED ADAVRSFLSG QGETVYRLGC IRERQGNEHQ TQVA 344
    Length:344
    Mass (Da):36,898
    Last modified:March 15, 2005 - v1
    Checksum:i2B0C48782E32F485
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004969 Genomic DNA. Translation: AAW89264.1.
    RefSeqiYP_207676.1. NC_002946.2.

    Genome annotation databases

    EnsemblBacteriaiAAW89264; AAW89264; NGO0526.
    GeneIDi3282922.
    KEGGingo:NGO0526.
    PATRICi20334098. VBINeiGon24812_0621.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004969 Genomic DNA. Translation: AAW89264.1 .
    RefSeqi YP_207676.1. NC_002946.2.

    3D structure databases

    ProteinModelPortali Q5F973.
    SMRi Q5F973. Positions 3-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 242231.NGO0526.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW89264 ; AAW89264 ; NGO0526 .
    GeneIDi 3282922.
    KEGGi ngo:NGO0526.
    PATRICi 20334098. VBINeiGon24812_0621.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi GEATCEV.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci NGON242231:GI2G-504-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Neisseria gonorrhoeae."
      Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H.
      , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700825 / FA 1090.

    Entry informationi

    Entry nameiPUR5_NEIG1
    AccessioniPrimary (citable) accession number: Q5F973
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3