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Q5F8Y0 (Q5F8Y0_NEIG1) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length916 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS006691

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1301O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
Q5F8Y0 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 3704364191D0F844

FASTA916101,385
        10         20         30         40         50         60 
MTDATIRHDH KFALETLPVS LEDEMRKSYL DYAMSVIVGR ALPDVRDGLK PVHRRVLYAM 

        70         80         90        100        110        120 
HELKNNWNAA YKKSARIVGD VIGKYHPHGD SAVYDTIVRM AQNFAMRYVL IDGQGNFGSV 

       130        140        150        160        170        180 
DGLAAAAMRY TEIRMAKISH EMLADIEEET VNFGPNYDGS EHEPLVLPTR FPTLLVNGSS 

       190        200        210        220        230        240 
GIAVGMATNI PPHNLTDTIN ACLRLLDEPK TEIDELIDII QAPDFPTGAT IYGLGGVREG 

       250        260        270        280        290        300 
YKTGRGRVVI RGKTHIEPIG KNGEREAIVI DEIPYQVNKA KLVEKIGDLV REKTLEGISE 

       310        320        330        340        350        360 
LRDESDKSGM RVVIELKRNE NAEVVLNQLY KLTPLQDSFG INMVVLVDGQ PRLLNLKQIL 

       370        380        390        400        410        420 
SEFLRHRREV VTRRTLFRLK KARHEGHIAE GKAVALSNID EIIKLIKESP NAAEAKEKLL 

       430        440        450        460        470        480 
ARPWRSSLVE EMLTRSGLDL EMMRPEGLAA NIGLKKQGYY LSEIQADAIL RMSLRNLTGL 

       490        500        510        520        530        540 
DQKEIIESYK NLMGKIIDFV DILSKPERIT QIIRDELEEI KTNYGDERRS EINPFGGDIA 

       550        560        570        580        590        600 
DEDLIPQREM VVTLTHGGYI KTQPTTDYQA QRRGGRGKQA AATKDEDFIE TLFVANTHDY 

       610        620        630        640        650        660 
LMCFTNLGKC HWIKVYKLPE GGRNSRGRPI NNVIQLEEGE KVSAILAVRE FPEDQYVFFA 

       670        680        690        700        710        720 
TAQGMVKKVQ LSAFKNVRAQ GIKAIALKEG DYLVGAAQTG GADDIMLFSN LGKAIRFNEY 

       730        740        750        760        770        780 
WEKSGNDEAE DADIETEISD DLEDETADNE NTLPSGKNGV RPSGRGSGGL RGMRLPADGK 

       790        800        810        820        830        840 
IVSLITFAPE TEESGLQVLT ATANGYGKRT PIADYSRKNK GGQGSIAINT GERNGDLVAA 

       850        860        870        880        890        900 
TLVGETDDLM LITSGGVLIR TKVEQIRETG RAAAGVKLIN LDEGETLVSL ERVAEDESEL 

       910 
SGASVISNVT EPEAEN 

« Hide

References

[1]"The complete genome sequence of Neisseria gonorrhoeae."
Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. expand/collapse author list , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700825 / FA 1090.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004969 Genomic DNA. Translation: AAW89357.1.
RefSeqYP_207769.1. NC_002946.2.

3D structure databases

ProteinModelPortalQ5F8Y0.
SMRQ5F8Y0. Positions 38-533.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING242231.NGO0629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW89357; AAW89357; NGO0629.
GeneID3282891.
KEGGngo:NGO0629.
PATRIC20334342. VBINeiGon24812_0743.

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAETVDWVP.
OrthoDBEOG661H5V.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycNGON242231:GI2G-597-MONOMER.

Family and domain databases

Gene3D1.10.268.10. 1 hit.
3.30.1360.40. 1 hit.
3.90.199.10. 1 hit.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. SSF56719. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ5F8Y0_NEIG1
AccessionPrimary (citable) accession number: Q5F8Y0
Entry history
Integrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)