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Protein

Glucose-6-phosphate isomerase 1

Gene

pgi1

Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 3531Proton donorUniRule annotation
Active sitei384 – 3841UniRule annotation
Active sitei512 – 5121UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciNGON242231:GI2G-679-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase 1UniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPI 1UniRule annotation
Alternative name(s):
Phosphoglucose isomerase 1UniRule annotation
Short name:
PGI 1UniRule annotation
Phosphohexose isomerase 1UniRule annotation
Short name:
PHI 1UniRule annotation
Gene namesi
Name:pgi1UniRule annotation
Ordered Locus Names:NGO0719
OrganismiNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Taxonomic identifieri242231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000535 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Glucose-6-phosphate isomerase 1PRO_0000180689Add
BLAST

Proteomic databases

PRIDEiQ5F8P8.

Interactioni

Protein-protein interaction databases

STRINGi242231.NGO0719.

Structurei

3D structure databases

ProteinModelPortaliQ5F8P8.
SMRiQ5F8P8. Positions 3-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F8P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLHDLPAW SKLWNHFDDS KTLHMREMFE QDPQRAERYW LQVGGLTLDY
60 70 80 90 100
SKNRINDETM SLLFELAREA GVPERMRQMF HGEKINTTEN RAVLHVALRN
110 120 130 140 150
RTNSPIMVDG EDVMPKVNRV LQRMGEFAHE VRSGSWLGYT NQVITDVVNI
160 170 180 190 200
GIGGSDLGPL TMCTALKPFG HPRLNMHFVS NVDGSQLRDV LSKVHPETTL
210 220 230 240 250
FIIASKTFTT QETLTNALTA REWFLNHAGD EEAVAKHFAA VSTNRKAVAE
260 270 280 290 300
FGIDIANMFE FWDWVGGRYS LWSAIGLPIM LYLGEENFIE MLNGAHLMDQ
310 320 330 340 350
HFINTPLERN LPVILALIGI WYINYYGGGS HVIAPYDQHL HRLPKFIQQL
360 370 380 390 400
DMESNGKQVT LDGKAVGHET SPIIWGETGI NGQHAFFQLL HQGTHITPID
410 420 430 440 450
LIASLEKRSN LPGHHEILLA NVFAQAEAFM CGKTPDEVRA ELKAQGMDEA
460 470 480 490 500
RIEELVPHKT FSGNRPTNLI LMDKVNPRNM GSLIAMYEHK TFVQGIIWGI
510 520 530 540
NSFDQWGVEL GKQLAKTILG ELTGETEPQK HDSSTERLIN LYLQTNRK
Length:548
Mass (Da):62,117
Last modified:March 14, 2005 - v1
Checksum:i704E606E2895007B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004969 Genomic DNA. Translation: AAW89439.1.
RefSeqiYP_207851.1. NC_002946.2.

Genome annotation databases

EnsemblBacteriaiAAW89439; AAW89439; NGO0719.
GeneIDi3282106.
KEGGingo:NGO0719.
PATRICi20334568. VBINeiGon24812_0856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004969 Genomic DNA. Translation: AAW89439.1.
RefSeqiYP_207851.1. NC_002946.2.

3D structure databases

ProteinModelPortaliQ5F8P8.
SMRiQ5F8P8. Positions 3-545.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi242231.NGO0719.

Proteomic databases

PRIDEiQ5F8P8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW89439; AAW89439; NGO0719.
GeneIDi3282106.
KEGGingo:NGO0719.
PATRICi20334568. VBINeiGon24812_0856.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciNGON242231:GI2G-679-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of Neisseria gonorrhoeae."
    Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H.
    , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700825 / FA 1090.

Entry informationi

Entry nameiG6PI1_NEIG1
AccessioniPrimary (citable) accession number: Q5F8P8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2005
Last sequence update: March 14, 2005
Last modified: January 6, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.