UniProtKB - Q5F8P8 (G6PI1_NEIG1)
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Protein
Glucose-6-phosphate isomerase 1
Gene
pgi1
Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Status
Functioni
Catalytic activityi
D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation
: glycolysis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotationProteins known to be involved in the 4 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Glucose-6-phosphate isomerase 1 (pgi1), Glucose-6-phosphate isomerase 2 (pgi2)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 353 | Proton donorUniRule annotation | 1 | |
Active sitei | 384 | UniRule annotation | 1 | |
Active sitei | 512 | UniRule annotation | 1 |
GO - Molecular functioni
- glucose-6-phosphate isomerase activity Source: UniProtKB-EC
GO - Biological processi
- gluconeogenesis Source: UniProtKB-KW
- glycolytic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Biological process | Gluconeogenesis, Glycolysis |
Enzyme and pathway databases
BioCyci | NGON242231:G1FZ9-668-MONOMER. |
UniPathwayi | UPA00109; UER00181. |
Names & Taxonomyi
Protein namesi | Recommended name: Glucose-6-phosphate isomerase 1UniRule annotation (EC:5.3.1.9UniRule annotation)Short name: GPI 1UniRule annotation Alternative name(s): Phosphoglucose isomerase 1UniRule annotation Short name: PGI 1UniRule annotation Phosphohexose isomerase 1UniRule annotation Short name: PHI 1UniRule annotation |
Gene namesi | Name:pgi1UniRule annotation Ordered Locus Names:NGO0719 |
Organismi | Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) |
Taxonomic identifieri | 242231 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180689 | 1 – 548 | Glucose-6-phosphate isomerase 1Add BLAST | 548 |
Proteomic databases
PRIDEi | Q5F8P8. |
Structurei
3D structure databases
ProteinModelPortali | Q5F8P8. |
SMRi | Q5F8P8. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the GPI family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000261370. |
KOi | K01810. |
OMAi | TNSQHAF. |
Family and domain databases
CDDi | cd05015. SIS_PGI_1. 1 hit. cd05016. SIS_PGI_2. 1 hit. |
Gene3Di | 1.10.1390.10. 1 hit. |
HAMAPi | MF_00473. G6P_isomerase. 1 hit. |
InterProi | View protein in InterPro IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. IPR035476. SIS_PGI_1. IPR035482. SIS_PGI_2. |
PANTHERi | PTHR11469. PTHR11469. 1 hit. |
Pfami | View protein in Pfam PF00342. PGI. 1 hit. |
PRINTSi | PR00662. G6PISOMERASE. |
PROSITEi | View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q5F8P8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKHLHDLPAW SKLWNHFDDS KTLHMREMFE QDPQRAERYW LQVGGLTLDY
60 70 80 90 100
SKNRINDETM SLLFELAREA GVPERMRQMF HGEKINTTEN RAVLHVALRN
110 120 130 140 150
RTNSPIMVDG EDVMPKVNRV LQRMGEFAHE VRSGSWLGYT NQVITDVVNI
160 170 180 190 200
GIGGSDLGPL TMCTALKPFG HPRLNMHFVS NVDGSQLRDV LSKVHPETTL
210 220 230 240 250
FIIASKTFTT QETLTNALTA REWFLNHAGD EEAVAKHFAA VSTNRKAVAE
260 270 280 290 300
FGIDIANMFE FWDWVGGRYS LWSAIGLPIM LYLGEENFIE MLNGAHLMDQ
310 320 330 340 350
HFINTPLERN LPVILALIGI WYINYYGGGS HVIAPYDQHL HRLPKFIQQL
360 370 380 390 400
DMESNGKQVT LDGKAVGHET SPIIWGETGI NGQHAFFQLL HQGTHITPID
410 420 430 440 450
LIASLEKRSN LPGHHEILLA NVFAQAEAFM CGKTPDEVRA ELKAQGMDEA
460 470 480 490 500
RIEELVPHKT FSGNRPTNLI LMDKVNPRNM GSLIAMYEHK TFVQGIIWGI
510 520 530 540
NSFDQWGVEL GKQLAKTILG ELTGETEPQK HDSSTERLIN LYLQTNRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE004969 Genomic DNA. Translation: AAW89439.1. |
RefSeqi | WP_003688725.1. NC_002946.2. YP_207851.1. NC_002946.2. |
Genome annotation databases
EnsemblBacteriai | AAW89439; AAW89439; NGO_0719. |
GeneIDi | 3282106. |
KEGGi | ngo:NGO0719. |
PATRICi | fig|242231.10.peg.856. |
Similar proteinsi
Entry informationi
Entry namei | G6PI1_NEIG1 | |
Accessioni | Q5F8P8Primary (citable) accession number: Q5F8P8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | February 28, 2018 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |