Q5F8P8 (G6PI1_NEIG1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase 1
Short name=GPI 1
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase 1
Short name=PGI 1
Phosphohexose isomerase 1
Short name=PHI 1

Gene names

Name:	pgi1
Ordered Locus Names:	NGO0719

Organism

Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) [Reference proteome] [HAMAP]

Taxonomic identifier

242231 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria gonorrhoeae

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-HAMAP glycolysis Inferred from electronic annotation. Source: UniProtKB-HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 548	548	Glucose-6-phosphate isomerase 1 HAMAP-Rule MF_00473		PRO_0000180689
Sites
	Active site	353	1	Proton donor By similarity
	Active site	384	1	By similarity
	Active site	512	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5F8P8 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 704E606E2895007B	FASTA	548	62,117
	10 20 30 40 50 60 MKHLHDLPAW SKLWNHFDDS KTLHMREMFE QDPQRAERYW LQVGGLTLDY SKNRINDETM 70 80 90 100 110 120 SLLFELAREA GVPERMRQMF HGEKINTTEN RAVLHVALRN RTNSPIMVDG EDVMPKVNRV 130 140 150 160 170 180 LQRMGEFAHE VRSGSWLGYT NQVITDVVNI GIGGSDLGPL TMCTALKPFG HPRLNMHFVS 190 200 210 220 230 240 NVDGSQLRDV LSKVHPETTL FIIASKTFTT QETLTNALTA REWFLNHAGD EEAVAKHFAA 250 260 270 280 290 300 VSTNRKAVAE FGIDIANMFE FWDWVGGRYS LWSAIGLPIM LYLGEENFIE MLNGAHLMDQ 310 320 330 340 350 360 HFINTPLERN LPVILALIGI WYINYYGGGS HVIAPYDQHL HRLPKFIQQL DMESNGKQVT 370 380 390 400 410 420 LDGKAVGHET SPIIWGETGI NGQHAFFQLL HQGTHITPID LIASLEKRSN LPGHHEILLA 430 440 450 460 470 480 NVFAQAEAFM CGKTPDEVRA ELKAQGMDEA RIEELVPHKT FSGNRPTNLI LMDKVNPRNM 490 500 510 520 530 540 GSLIAMYEHK TFVQGIIWGI NSFDQWGVEL GKQLAKTILG ELTGETEPQK HDSSTERLIN LYLQTNRK

References

[1]

"The complete genome sequence of Neisseria gonorrhoeae." Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700825 / FA 1090.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004969 Genomic DNA. Translation: AAW89439.1.
RefSeq	YP_207851.1. NC_002946.2.
3D structure databases
ProteinModelPortal	Q5F8P8.
SMR	Q5F8P8. Positions 3-545.
ModBase	Search...
Protein-protein interaction databases
STRING	242231.NGO0719.
Proteomic databases
PRIDE	Q5F8P8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAW89439; AAW89439; NGO0719.
GeneID	3282106.
KEGG	ngo:NGO0719.
PATRIC	20334568. VBINeiGon24812_0856.
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HOG000261370.
KO	K01810.
OMA	LKMHFVS.
OrthoDB	EOG64R61J.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	NGON242231:GI2G-679-MONOMER.
UniPathway	UPA00109; UER00181.
Family and domain databases
Gene3D	1.10.1390.10. 1 hit.
HAMAP	MF_00473. G6P_isomerase.
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. PTHR11469. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI1_NEIG1

Accession

Primary (citable) accession number: Q5F8P8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	March 15, 2005
Last modified:	November 13, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program