pgi1

Functionⁱ

Catalytic activityⁱ

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

no protein annotated in this organism
Glucose-6-phosphate isomerase 1 (pgi1), Glucose-6-phosphate isomerase 2 (pgi2)
no protein annotated in this organism
no protein annotated in this organism

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	353	Proton donorUniRule annotation	1
Active siteⁱ	384	UniRule annotation	1
Active siteⁱ	512	UniRule annotation	1

GO - Molecular functionⁱ

glucose-6-phosphate isomerase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-KW
glycolytic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181.

UniPathwayⁱ

UPA00109; UER00181.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucose-6-phosphate isomerase 1UniRule annotation (EC:5.3.1.9UniRule annotation) Short name: GPI 1UniRule annotation Alternative name(s): Phosphoglucose isomerase 1UniRule annotation Short name: PGI 1UniRule annotation Phosphohexose isomerase 1UniRule annotation Short name: PHI 1UniRule annotation
Gene namesⁱ	Name:pgi1UniRule annotation Ordered Locus Names:NGO0719
Organismⁱ	Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Taxonomic identifierⁱ	242231 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria gonorrhoeae
Proteomesⁱ	UP000000535 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00473

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000180689	1 – 548	Glucose-6-phosphate isomerase 1Add BLAST		548

Proteomic databases

PRIDEⁱ	Q5F8P8.

PRIDEⁱ

Q5F8P8.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5F8P8.
SMRⁱ	Q5F8P8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000261370.
KEGG Orthology (KO) More...KOⁱ	K01810.
OMAⁱ	TNSQHAF.

Family and domain databases

Gene3Dⁱ	1.10.1390.10. 1 hit.
HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	View protein in InterPro IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS.
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342. PGI. 1 hit.
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5F8P8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKHLHDLPAW SKLWNHFDDS KTLHMREMFE QDPQRAERYW LQVGGLTLDY 
        60         70         80         90        100
SKNRINDETM SLLFELAREA GVPERMRQMF HGEKINTTEN RAVLHVALRN 
       110        120        130        140        150
RTNSPIMVDG EDVMPKVNRV LQRMGEFAHE VRSGSWLGYT NQVITDVVNI 
       160        170        180        190        200
GIGGSDLGPL TMCTALKPFG HPRLNMHFVS NVDGSQLRDV LSKVHPETTL 
       210        220        230        240        250
FIIASKTFTT QETLTNALTA REWFLNHAGD EEAVAKHFAA VSTNRKAVAE 
       260        270        280        290        300
FGIDIANMFE FWDWVGGRYS LWSAIGLPIM LYLGEENFIE MLNGAHLMDQ 
       310        320        330        340        350
HFINTPLERN LPVILALIGI WYINYYGGGS HVIAPYDQHL HRLPKFIQQL 
       360        370        380        390        400
DMESNGKQVT LDGKAVGHET SPIIWGETGI NGQHAFFQLL HQGTHITPID 
       410        420        430        440        450
LIASLEKRSN LPGHHEILLA NVFAQAEAFM CGKTPDEVRA ELKAQGMDEA 
       460        470        480        490        500
RIEELVPHKT FSGNRPTNLI LMDKVNPRNM GSLIAMYEHK TFVQGIIWGI 
       510        520        530        540 
NSFDQWGVEL GKQLAKTILG ELTGETEPQK HDSSTERLIN LYLQTNRK

Length:548

Mass (Da):62,117

Last modified:March 15, 2005 - v1

Checksum:ⁱ704E606E2895007B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE004969 Genomic DNA. Translation: AAW89439.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_003688725.1. NC_002946.2. YP_207851.1. NC_002946.2.

Genome annotation databases

EnsemblBacteriaⁱ	AAW89439; AAW89439; NGO_0719.
GeneIDⁱ	3282106.
KEGGⁱ	ngo:NGO_0719.
PATRICⁱ	fig\|242231.10.peg.856.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE004969 Genomic DNA. Translation: AAW89439.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_003688725.1. NC_002946.2. YP_207851.1. NC_002946.2.

3D structure databases

ProteinModelPortalⁱ	Q5F8P8.
SMRⁱ	Q5F8P8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	Q5F8P8.

PRIDEⁱ

Q5F8P8.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAW89439; AAW89439; NGO_0719.
GeneIDⁱ	3282106.
KEGGⁱ	ngo:NGO_0719.
PATRICⁱ	fig\|242231.10.peg.856.

Phylogenomic databases

HOGENOMⁱ	HOG000261370.
KEGG Orthology (KO) More...KOⁱ	K01810.
OMAⁱ	TNSQHAF.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181.

UniPathwayⁱ

UPA00109; UER00181.

Family and domain databases

Gene3Dⁱ	1.10.1390.10. 1 hit.
HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	View protein in InterPro IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS.
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342. PGI. 1 hit.
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G6PI1_NEIG1
Accessionⁱ	Q5F8P8Primary (citable) accession number: Q5F8P8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	March 15, 2005
	Last modified:	June 7, 2017
	This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5F8P8 (G6PI1_NEIG1)

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Glucose-6-phosphate isomerase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ